The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Mutations arising in the wave front of an expanding population
Open accessAbstract
The ability to infer the time and place of origin of a mutation can be very useful when reconstructing the evolutionary histories of populations and species. We use forward computer simulations of population growth, migration, and mutation in an analysis of an expanding population with a wave front that advances at a constant slow rate. A pronounced founder effect can be observed among mutations arising in this wave front where extreme population bottlenecks arise and are followed by major population growth. A fraction of mutations travel with the wave front and generate mutant populations that are on average much larger than those that remain stationary. Analysis of the diffusion of these mutants makes it possible to reconstruct migratory trajectories during population expansions, thus helping us better understand observed patterns in the evolution of species such as modern humans. Examination of some historical data supports our model.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“According to the expansion hypothesis (19), as HGs spread over Europe, their NE introgression levels increased because of a combination of stochastic demographic and migratory processes related to gene dilution (20, 31, 39) and gene surfing (22, 23), which explain the spatial gradients of NE ancestry observed in HGs (Fig. 5).”
From Past human expansions shaped the spatial pattern of Neanderthal ancestry (2023) · cites this paper as [22]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
THE WAVE OF ADVANCE OF ADVANTAGEOUS GENES
Fisher, R. A. (1937) · Annals of Eugenics · doi:10.1111/j.1469-1809.1937.tb02153.x · Cited by 4,937
The History and Geography of Human Genes
Cavalli-Sforza, L. L., Menozzi, P., & Piazza, A. (2018) · Princeton University Press eBooks · doi:10.2307/j.ctv301gjp · Cited by 3,175
Self-citationRANDOM DISPERSAL IN THEORETICAL POPULATIONS
Skellam, J. G. (1951) · Biometrika · doi:10.1093/biomet/38.1-2.196 · Cited by 2,637
History and Geography of Human Genes
Piazza, A. (1994) · Advances in forensic haemogenetics · doi:10.1007/978-3-642-78782-9_1 · Cited by 1,639
Natural selection shaped regional mtDNA variation in humans
Mishmar, D., Ruiz‐Pesini, E., Golik, P., Macaulay, V. A., Clark, A. G., Hosseini, S., Brandon, M., Easley, K. A., Chen, E., Brown, M. D., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0136972100 · Cited by 1,040
The Neolithic Transition and the Genetics of Populations in Europe
Ammerman, A. J., & Cavalli-Sforza, L. L. (1984) · Princeton University Press eBooks · doi:10.1515/9781400853113 · Cited by 979
Self-citationThe phylogeography of Y chromosome binary haplotypes and the origins of modern human populations
Underhill, P. A., Passarino, G., Lin, A. A., Shen, P., Lahr, M. M., Foley, R., Oefner, P. J., & Cavalli-Sforza, L. L. (2001) · Annals of Human Genetics · doi:10.1046/j.1469-1809.2001.6510043.x · Cited by 782
Self-citationThe genetics of human populations
Cavalli-Sforza, L. L. (1974) · Journal of Human Evolution · doi:10.1016/0047-2484(74)90135-3 · Cited by 724
Self-citationThe application of molecular genetic approaches to the study of human evolution
Cavalli-Sforza, L. L., & Feldman, M. W. (2003) · Nature Genetics · doi:10.1038/ng1113 · Cited by 685
Self-citationParkington, J. E., & Klein, R. B. (1989) · Cited by 558
Research works printed but not linked: 2
- Rendine, S., Piazza, A. & Cavalli-Sforza, L. L. (1986) Am. Nat. 128, 762–768.
- Vlad, M. O., Moran, F., Tsuchiya, M., Cavalli-Sforza, L. L., Oefner, P. J. & Ross, J. (2002) Phys. Rev. E. 65, 061110-1–061110-17.
Cited by
Sorted by citations
Items 401–429 of 429
Population Structure of Pathogenic Bacteria
Qiu, X., Challagundla, L., Senghore, M., Hanage, W. P., & Robinson, D. A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-28818-0.00011-2
Batova, O. N., Markov, N., Titov, S. V., & Tchabovsky, A. V. (2024) · Animals · doi:10.3390/ani14182720
Asymmetric Interactions Shape Survival During Population Range ExpansionsPreprint
Gray, J. M., Barker-Clarke, R. J., Scott, J. G., & Hinczewski, M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.14.628506
Management of invasive populations
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0009
Stochasticity and invasion fronts
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0004
Phillips, B. L. (2025) · doi:10.1093/9780191924910.005.0001
Stochastic evolutionary processes on invasion fronts
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0005
Phillips, B. L. (2025) · doi:10.1093/9780191924910.002.0002
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0003
Why do populations invade new areas?
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0002
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0007
Phillips, B. L. (2025) · doi:10.1093/9780191924910.005.0004
Probability distributions, random numbers, and simulation
Phillips, B. L. (2025) · doi:10.1093/9780191924910.005.0002
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0006
Natural invasions with documented trait shifts
Phillips, B. L. (2025) · doi:10.1093/9780191924910.005.0003
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0008
Phillips, B. L. (2025) · doi:10.1093/9780191924910.003.0001
Using genomic tools to understand species differentiation and admixture in hares and mice
Marques, J. P. (2022) · theses.fr (ABES) · doi:10.70675/4a9cb331z69c9z4867z8dbezfa019b800e6b
Scaling limits of branching and coalescing models arising in population biology
Foutel‐Rodier, F. (2021) · theses.fr (ABES) · doi:10.70675/1ae37204z7145z4f7fzac1dze11d4b6c51a9
Sahakyan, H., Reidla, M., Metspalu, E., Kuznetsov, I. A., Flores, R., Irdt, K., Utevska, O., Pathak, A. K., Reščenko, R., Rovīte, V., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10447855/v1
Quintela, M., Prodöhl, P. A., Jansson, E., Besnier, F., Dahle, G., Glover, K. A., & Agnalt, A. (2026) · ICES Journal of Marine Science · doi:10.1093/icesjms/fsag165
Living on the Edge: Ecological and Evolutionary Dynamics Along Invasion Fronts
Haubrock, P. J., Abreo, N. A. S., Katsanevakis, S., Essl, F., Tarkan, A. S., Padilha, J. D. A. G., Hulme, P. E., Ahmed, D. A., Nogueira, A. B., Everts, T., et al. (2026) · Ecology Letters · doi:10.1111/ele.70465
Metadata
- Authors
- Edmonds, C. A., Lillie, A. S., & Cavalli-Sforza, L. L.
- Affiliations
- Stanford Medicine (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-01-19
- Volume
- 101
- Issue
- 4
- Pages
- 975-979
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC327127
- OpenAlex
- W2051334294
- Cited by
- 429
- References
- 12
- Citations by year
- 2026: 6 · 2025: 24 · 2024: 13 · 2023: 19 · 2022: 17 · 2021: 20 · 2020: 15 · 2019: 18 · 2018: 38 · 2017: 21 · 2016: 29 · 2015: 22 · 2014: 22 · 2013: 24 · 2012: 27
- FWCI
- 6.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (28428)
- National Institute of General Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- mutation origin, founder effect, population growth, wavefronts, population bottleneck, migration, migratory trajectories, human evolution, population genetics, forward modeling
- MeSH terms
- Biological Evolution, Mutation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
