The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus
Open accessAbstract
The 1918 influenza A H1N1 virus caused the worst pandemic of influenza ever recorded. To better understand the pathogenesis and immunity to the 1918 pandemic virus, we generated recombinant influenza viruses possessing two to five genes of the 1918 influenza virus. Recombinant influenza viruses possessing the hemagglutinin (HA), neuraminidase (NA), matrix (M), nonstructural (NS), and nucleoprotein (NP) genes or any recombinant virus possessing both the HA and NA genes of the 1918 influenza virus were highly lethal for mice. Antigenic analysis by hemagglutination inhibition (HI) tests with ferret and chicken H1N1 antisera demonstrated that the 1918 recombinant viruses antigenically most resembled A/Swine/Iowa/30 (Sw/Iowa/30) virus but differed from H1N1 viruses isolated since 1930. HI and virus neutralizing (VN) antibodies to 1918 recombinant and Sw/Iowa/30 viruses in human sera were present among individuals born before or shortly after the 1918 pandemic. Mice that received an intramuscular immunization of the homologous or Sw/Iowa/30-inactivated vaccine developed HI and VN antibodies to the 1918 recombinant virus and were completely protected against lethal challenge. Mice that received A/PR/8/34, A/Texas/36/91, or A/New Caledonia/20/99 H1N1 vaccines displayed partial protection from lethal challenge. In contrast, control-vaccinated mice were not protected against lethal challenge and displayed high virus titers in respiratory tissues. Partial vaccine protection mediated by baculovirus-expressed recombinant HA vaccines suggest common cross-reactive epitopes on the H1 HA. These data suggest a strategy of vaccination that would be effective against a reemergent 1918 or 1918-like virus.
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Cites
Initial Genetic Characterization of the 1918 “Spanish” Influenza Virus
Taubenberger, J. K., Reid, A. H., Krafft, A. E., Bijwaard, K. E., & Fanning, T. G. (1997) · Science · doi:10.1126/science.275.5307.1793 · Cited by 715
Self-citationOrigin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene
Reid, A. H., Fanning, T. G., Hultin, J. V., & Taubenberger, J. K. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1651 · Cited by 607
Self-citationFrost, W. H. (1920) · Public Health Reports (1896-1970) · doi:10.2307/4575511 · Cited by 118
Cited by
Characterization of the reconstructed 1918 Spanish influenza pandemic virus
Tumpey, T. M., Basler, C. F., Aguilar, P. V., Zeng, H., Solórzano, A., Swayne, D. E., Cox, N. J., Katz, J. M., Taubenberger, J. K., Palese, P., et al. (2005) · Science · doi:10.1126/science.1119392 · Cited by 1,327
Self-citationCharacterization of the 1918 influenza virus polymerase genes
Taubenberger, J. K., Reid, A. H., Lourens, R. M., Wang, R., Jin, G., & Fanning, T. G. (2005) · Nature · doi:10.1038/nature04230 · Cited by 1,066
Self-citationInfluenza: lessons from past pandemics, warnings from current incidents
Horimoto, T., & Kawaoka, Y. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1208 · Cited by 696
Perrone, L. A., Plowden, J. K., García-Sastre, A., Katz, J. M., & Tumpey, T. M. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000115 · Cited by 623
Self-citationTumpey, T. M., García-Sastre, A., Taubenberger, J. K., Palese, P., Swayne, D. E., Pantin-Jackwood, M. J., Schultz-Cherry, S., Solórzano, A., Van Rooijen, N., Katz, J. M., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.23.14933-14944.2005 · Cited by 507
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Metadata
- Authors
- Tumpey, T. M., García-Sastre, A., Taubenberger, J. K., Palese, P., Swayne, D. E., & Basler, C. F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-02-12
- Volume
- 101
- Issue
- 9
- Pages
- 3166-3171
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965587444
- Cited by
- 175
- References
- 3
- FWCI
- 9.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Tumpey, T. M., García-Sastre, A., Taubenberger, J. K., Palese, P., Swayne, D. E., & Basler, C. F. (2004). Pathogenicity and immunogenicity of influenza viruses with genes from the 1918 pandemic virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308391100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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