The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice
Open accessAbstract
Fatal human respiratory disease associated with the 1918 pandemic influenza virus and potentially pandemic H5N1 viruses is characterized by severe lung pathology, including pulmonary edema and extensive inflammatory infiltrate. Here, we quantified the cellular immune response to infection in the mouse lung by flow cytometry and demonstrate that mice infected with highly pathogenic (HP) H1N1 and H5N1 influenza viruses exhibit significantly high numbers of macrophages and neutrophils in the lungs compared to mice infected with low pathogenic (LP) viruses. Mice infected with the 1918 pandemic virus and a recent H5N1 human isolate show considerable similarities in overall lung cellularity, lung immune cell sub-population composition, and cellular immune temporal dynamics. Interestingly, while these similarities were observed, the HP H5N1 virus consistently elicited significantly higher levels of pro-inflammatory cytokines in whole lungs and primary human macrophages, revealing a potentially critical difference in the pathogenesis of H5N1 infections. Primary mouse and human macrophages and dendritic cells were also susceptible to 1918 and H5N1 influenza virus infection in vitro. These results together indicate that infection with HP influenza viruses such as H5N1 and the 1918 pandemic virus leads to a rapid cell recruitment of macrophages and neutrophils into the lungs, suggesting that these cells play a role in acute lung inflammation associated with HP influenza virus infection.
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Cites
Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia.
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Self-citationAberrant innate immune response in lethal infection of macaques with the 1918 influenza virus.
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Cited by
Narasaraju, T., Yang, E., Samy, R. P., Ng, H. H., Poh, W. P., Liew, A.-A., Phoon, M. C., van Rooijen, N., & Chow, V. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.03.013 · Cited by 890
Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis
Robinson, D. P., & Klein, S. L. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2012.02.023 · Cited by 709
Trompette, A., Gollwitzer, E. S., Pattaroni, C., Lopez-Mejia, I. C., Riva, E., Pernot, J., Ubags, N., Fajas, L., Nicod, L. P., & Marsland, B. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.022 · Cited by 678
Influenza A viruses: new research developments
Medina, R. A., & García-Sastre, A. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2613 · Cited by 677
Self-citationThe airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Metadata
- Authors
- Perrone, L. A., Plowden, J. K., García-Sastre, A., Katz, J. M., & Tumpey, T. M.
- Venue
- PLoS Pathogens
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-08-01
- Volume
- 4
- Issue
- 8
- Pages
- e1000115
- ISSN
- 1553-7366 (ISSN-L)
- 1553-7374
- OpenAlex
- W2031997312
- Cited by
- 623
- References
- 48
- FWCI
- 31.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice. https://app.cochat.ai/papers/10.1371/journal.ppat.1000115
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- Perrone, L. A., Plowden, J. K., García-Sastre, A., Katz, J. M., & Tumpey, T. M. (2008). H5N1 and 1918 Pandemic Influenza Virus Infection Results in Early and Excessive Infiltration of Macrophages and Neutrophils in the Lungs of Mice. PLoS Pathogens. https://doi.org/10.1371/journal.ppat.1000115
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
