The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations
Open accessAbstract
Most adaptation is thought to occur through the fixation of numerous alleles at many different loci. Consequently, the independent evolution of similar phenotypes is predicted to occur through different genetic mechanisms. The genetic basis of adaptation is still largely unknown, however, and it is unclear whether adaptation to new environments utilizes ubiquitous small-effect polygenic variation or large-effect alleles at a small number of loci. To address this question, we examined the genetic basis of bony armor loss in three freshwater populations of Alaskan threespine stickleback,Gasterosteus aculeatus, that evolved from fully armored anadromous populations in the last 14,000 years. Crosses between complete-armor and low-armor populations revealed that a single Mendelian factor governed the formation of all but the most anterior lateral plates, and another independently segregating factor largely determined pelvic armor. Genetic mapping localized the Mendelian genes to different chromosomal regions, and crosses among these same three widely separated populations showed that both bony plates and pelvic armor failed to fully complement, implicating the same Mendelian armor reduction genes. Thus, rapid and repeated armor loss in Alaskan stickleback populations appears to be occurring through the fixation of large-effect variants in the same genes.
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Cites
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Cited by
The evolutionary significance of cis-regulatory mutations
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Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
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Adaptive Evolution of Pelvic Reduction in Sticklebacks by Recurrent Deletion of a Pitx1 Enhancer
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Metadata
- Authors
- Cresko, W. A., Amores, A., Wilson, C., Murphy, J., Currey, M., Phillips, P., Bell, M. A., Kimmel, C. B., & Postlethwait, J. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-04-06
- Volume
- 101
- Issue
- 16
- Pages
- 6050-6055
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2153402526
- Cited by
- 359
- References
- 35
- FWCI
- 10.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Cresko, W. A., Amores, A., Wilson, C., Murphy, J., Currey, M., Phillips, P., Bell, M. A., Kimmel, C. B., & Postlethwait, J. H. (2004). Parallel genetic basis for repeated evolution of armor loss in Alaskan threespine stickleback populations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0308479101
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