The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
Open accessAbstract
Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila . The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.
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Cites
Phillips, J. P., Campbell, S. D., Michaud, D., Charbonneau, M., & Hilliker, A. J. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.8.2761 · Cited by 389
Moskovitz, J., Rahman, M. A., Strassman, J., Yancey, S. O., Kushner, S. R., Brot, N., & Weissbach, H. (1995) · Journal of Bacteriology · doi:10.1128/jb.177.3.502-507.1995 · Cited by 294
Self-citation
Cited by
Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases
Lin, M. T., & Beal, M. F. (2006) · Nature · doi:10.1038/nature05292 · Cited by 6,455
A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
Erickson, J. R., Joiner, M.-L. A., Guan, X., Kutschke, W., Yang, J., Oddis, C. V., Bartlett, R. K., Lowe, J. S., O'Donnell, S. E., Aykin-Burns, N., et al. (2008) · Cell · doi:10.1016/j.cell.2008.02.048 · Cited by 1,122
Self-citationTrends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Mitochondria take center stage in aging and neurodegeneration
Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957
Kaushik, S., & Cuervo, A. M. (2015) · Nature Medicine · doi:10.1038/nm.4001 · Cited by 899
Metadata
- Authors
- Ruan, H., Tang, X. D., Chen, M.-L., Joiner, M. A., Sun, G., Brot, N., Weissbach, H., Heinemann, S. H., Iverson, L., Wu, C.-F., & Hoshi, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2002-02-26
- Volume
- 99
- Issue
- 5
- Pages
- 2748-2753
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2013342221
- Cited by
- 454
- References
- 2
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- green
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- Ruan, H., Tang, X. D., Chen, M.-L., Joiner, M. A., Sun, G., Brot, N., Weissbach, H., Heinemann, S. H., Iverson, L., Wu, C.-F., & Hoshi, T. (2002). High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.032671199
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