Trends in oxidative aging theories

Muller, Florian L.; Lustgarten, Michael S.; Jang, Youngmok; Richardson, Arlan; Van Remmen, Holly

doi:10.1016/j.freeradbiomed.2007.03.034

Cited by 1,053Genetics, Aging, and Longevity in Model OrganismsRedox biology and oxidative stressTelomeres, Telomerase, and Senescence

Trends in oxidative aging theories

Muller, Florian L., Lustgarten, Michael S., Jang, Youngmok, Richardson, Arlan, Van Remmen, Holly·2007·Free Radical Biology and Medicine

DOI 10.1016/j.freeradbiomed.2007.03.034

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Abstract

The early observations on the rate-of-living theory by Max Rubner and the report by Gershman that oxygen free radicals exist in vivo culminated in the seminal proposal in the 1950s by Denham Harman that reactive oxygen species are a cause of aging (free radical theory of aging). The goal of this review is to analyze recent findings relevant in evaluating Harman's theory using experimental results as grouped by model organisms (i.e., invertebrate models and mice). In this regard, we have focused primarily on recent work involving genetic manipulations. Because the free radical theory of aging is not the only theorem proposed to explain the mechanism(s) involved in aging at the molecular level, we also discuss how this theory is related to other areas of research in biogerontology, specifically, telomere/cell senescence, genomic instability, and the mitochondrial hypothesis of aging. We also discuss where we think the free radical theory is headed. It is now possible to give at least a partial answer to the question whether oxidative stress determines life span as Harman posed so long ago. Based on studies to date, we argue that a tentative case for oxidative stress as a life-span determinant can be made in Drosophila melanogaster. Studies in mice argue for a role of oxidative stress in age-related disease, especially cancer; however, with regard to aging per se, the data either do not support or remain inconclusive on whether oxidative stress determines life span.

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Multiple lines of evidence suggest that progressive oxidative damage is a conserved, central mechanism of age-related functional decline.
“Multiple lines of evidence suggest that progressive oxidative damage is a conserved, central mechanism of age-related functional decline (42).”
From Neural mechanisms of ageing and cognitive decline (2010) · cites this paper as [42]

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Authors: Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
ORCID: Lustgarten, Michael S.
Richardson, Arlan
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2007-08
Volume: 43
Issue: 4
Pages: 477-503
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/j.freeradbiomed.2007.03.034
OpenAlex: W2132673369
Cited by: 1,053
References: 38
Citations by year: 2026: 11 · 2025: 12 · 2024: 19 · 2023: 21 · 2022: 23 · 2021: 39 · 2020: 51 · 2019: 47 · 2018: 49 · 2017: 57 · 2016: 51 · 2015: 68 · 2014: 75 · 2013: 86 · 2012: 95
FWCI: 7.41
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Keywords: free radical theory of aging, oxidative stress, rate of living theory, reactive oxygen species, oxygen free radicals, harman, lifespan, genomic instability, age-related diseases, cancer, Drosophila melanogaster, mice, genetic engineering
MeSH terms: Aging, Animals, Humans, Telomere, Cellular Senescence, Reactive Oxygen Species, Oxidative Stress, Genomic Instability

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