The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
Open accessAbstract
Histone deacetylase (HDAC) activity, commonly correlated with transcriptional repression, was essential for transcriptional induction of IFN-stimulated genes (ISG). Inhibition of HDAC function led to global impairment of ISG expression, with little effect on basal expression. HDAC function was not required for signal transducer and activator of transcription tyrosine phosphorylation, nuclear translocation, or assembly on chromatin, but it was needed for full activity of the signal transducer and activator of transcription transactivation domain. HDAC function was also required for gene induction driven by the IFN regulatory factor 3 transcription factor activated by virus infection, and it was essential for establishment of an antiviral response against Flaviviridae, Rhabdoviridae, and Picornaviridae. Requirement for HDAC function in transcriptional activation may represent a general mechanism for rapid stimulation of ISG transcription.
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Cites
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Self-citationWathelet, M. G., Lin, C. H., Parekh, B. S., Ronco, L. V., Howley, P. M., & Maniatis, T. (1998) · Molecular Cell · doi:10.1016/s1097-2765(00)80051-9 · Cited by 730
Brosch, G., Ransom, R., Lechner, T., Walton, J. D., & Loidl, P. (1995) · The Plant Cell · doi:10.1105/tpc.7.11.1941 · Cited by 204
Cited by
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Falkenberg, K. J., & Johnstone, R. W. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4360 · Cited by 1,564
Russell, S. J., Peng, K.-W., & Bell, J. C. (2012) · Nature Biotechnology · doi:10.1038/nbt.2287 · Cited by 1,428
Hu, X., & Ivashkiv, L. B. (2009) · Immunity · doi:10.1016/j.immuni.2009.09.002 · Cited by 928
Ghisletti, S., Huang, W., Ogawa, S., Pascual, G., Lin, M.-E., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.022 · Cited by 561
The regulation of matrix metalloproteinases and their inhibitors
Clark, I. M., Swingler, T. E., Sampieri, C. L., & Edwards, D. R. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2007.12.006 · Cited by 555
Metadata
- Authors
- Chang, H.-M., Paulson, M., Holko, M., Rice, C. M., Williams, B. R. G., Marié, I., & Levy, D. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-06-21
- Volume
- 101
- Issue
- 26
- Pages
- 9578-9583
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1976555683
- Cited by
- 212
- References
- 3
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- green
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- Chang, H.-M., Paulson, M., Holko, M., Rice, C. M., Williams, B. R. G., Marié, I., & Levy, D. E. (2004). Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0400567101
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