The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans
Open accessAbstract
Aging is characterized by progressive, degenerative changes in many tissues. To elucidate the relationships among degenerative changes in Caenorhabditis elegans , we developed methods to measure age-related changes quantitatively and analyzed correlations among these changes by using a longitudinal study. The age-related declines of pharyngeal pumping and body movement were positively correlated with each other and lifespan. These findings suggest that the declines of pharyngeal pumping and body movement cause a decline in survival probability or that a shared regulatory system mediates the declines in pharyngeal pumping, body movement, and survival probability. Furthermore, measurements of these processes can be used to predict lifespan and detect premature aging. The declines of physiological processes were measured in daf-2 , age-1 , daf-16 , eat-2 , and clk-1 mutants that have altered lifespans. Each mutant strain displayed changes in one or more age-related declines, but the correlations among age-related changes were similar to WT. These measurements were used to generate a system of four stages that describes the aging process and is useful for the analysis of genetic and environmental effects on aging.
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Cites
Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans
Herndon, L. A., Schmeissner, P. J., Dudaronek, J. M., Brown, P. A., Listner, K. M., Sakano, Y., Paupard, M. C., Hall, D. H., & Driscoll, M. (2002) · Nature · doi:10.1038/nature01135 · Cited by 1,214
Cited by
Onken, B., & Driscoll, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008758 · Cited by 671
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
Ben-Zvi, A., Miller, E. A., & Morimoto, R. I. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0902882106 · Cited by 649
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648
Insulin/insulin-like growth factor signaling in C. elegans
Murphy, C. T. (2013) · WormBook · doi:10.1895/wormbook.1.164.1 · Cited by 532
Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants
Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1412192112 · Cited by 367
Metadata
- Authors
- Huang, C., Xiong, C., & Kornfeld, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-05-12
- Volume
- 101
- Issue
- 21
- Pages
- 8084-8089
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2058127437
- Cited by
- 528
- References
- 1
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
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- Huang, C., Xiong, C., & Kornfeld, K. (2004). Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0400848101
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