Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants

Bansal, Ankita; Zhu, Lihua J.; Yen, Kelvin; Tissenbaum, Heidi A.

doi:10.1073/pnas.1412192112

Cited by 367Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and SenescenceNeurobiology and Insect Physiology Research

Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants

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Bansal, Ankita, Zhu, Lihua J., Yen, Kelvin, Tissenbaum, Heidi A.·2015·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1412192112PMC PMC4311797

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Abstract

Significance: Genetic and environmental manipulations have been identified that result in lifespan extension. The underlying assumption that lifespan extension would also result in an increase in healthspan is seemingly valid but infrequently examined. Here, we examined multiple pathways that modulate lifespan to investigate the relationship between lifespan extension and health. We analyzed wild-type and four long-lived mutants in an unbiased cross-sectional study with multiple assays until animals reached 80% maximum lifespan. We show lifespan and healthspan can be separated and all of the long-lived mutants extend the period of frailty as a consequence. If applied to humans, this would likely lead to unsustainable healthcare costs and demonstrates the importance of examining healthspan as opposed to lifespan for future research.

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Genetic interventions that extend lifespan in C. elegans may do so without comparably altering the relevant aging phenotypes.
“Evidence in C. elegans has provided support for this idea by demonstrating that genetic interventions that extend lifespan may do so without comparably altering the relevant aging phenotypes.17”
From Asynchronous, contagious and digital aging (2021) · cites this paper as [17]

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Authors: Bansal, A., Zhu, L. J., Yen, K., & Tissenbaum, H. A.
Affiliations: Programs in aGene Function and Expression,
University of Massachusetts Chan Medical School (US)
ORCID: Bansal, Ankita
Zhu, Lihua J.
Yen, Kelvin
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2015-01-05
Volume: 112
Issue: 3
Pages: E277-86
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1412192112
PMC: PMC4311797
OpenAlex: W2119146677
Cited by: 367
References: 68
Citations by year: 2026: 31 · 2025: 28 · 2024: 35 · 2023: 40 · 2022: 31 · 2021: 25 · 2020: 39 · 2019: 31 · 2018: 30 · 2017: 26 · 2016: 31 · 2015: 18
FWCI: 14.02
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health (P40OD010440)
National Institute on Aging (R01AG025891, AG025891)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords: healthspan, lifespan, aging, Caenorhabditis elegans, insulin/IGF-1 signaling, dietary restriction, mRNA translation, mitochondrial signaling, frailty, age-related diseases
MeSH terms: Animals, Longevity, Movement, Mutation, Caenorhabditis elegans

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Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants

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