The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
Neuroprotectin D1: A docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
Open accessAbstract
Docosahexaenoic acid (DHA) is a lipid peroxidation target in oxidative injury to retinal pigment epithelium (RPE) and retina. Photoreceptor and synaptic membranes share the highest content of DHA of all cell membranes. This fatty acid is required for RPE functional integrity; however, it is not known whether specific mediators generated from DHA contribute to its biological significance. We used human ARPE-19 cells and demonstrated the synthesis of 10,17S-docosatriene [neuroprotectin D1 (NPD1)]. This synthesis was enhanced by the calcium ionophore A-23187, by IL-1beta, or by supplying DHA. Under these conditions, there is a time-dependent release of endogenous free DHA followed by NPD1 formation, suggesting that phospholipase A(2) releases the mediator's precursor. Added NPD1 potently counteracted H(2)O(2)/tumor necrosis factor alpha oxidative-stress-triggered apoptotic RPE DNA damage. NPD1 also up-regulated the antiapoptotic proteins Bcl-2 and Bcl-x(L) and decreased proapoptotic Bax and Bad expression. Moreover, NPD1 (50 nM) inhibited oxidative-stress-induced caspase-3 activation. NPD1 also inhibited IL-1beta-stimulated expression of cyclooxygenase 2 promoter transfected into ARPE-19 cells. Overall, NPD1 protected RPE cells from oxidative-stress-induced apoptosis, and we predict that it will similarly protect neurons. This lipid mediator therefore may indirectly contribute to photoreceptor cell survival as well. Because both RPE and photoreceptor cells die in retinal degenerations, our findings contribute to the understanding of retinal cell survival signaling and potentially to the development of new therapeutic strategies.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“DHA then ends up amounting to more than 50% of OS phospholipid fatty acyl chains and therefore DHA-containing phospholipids in the retina and other cells are reservoirs for docosanoids (Bazan et al., 1984; Mukherjee et al., 2004).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Mukherjee et al., 2004
In the citing paper
“In fact, NPD1 also induces the anti-apoptotic Bcl-2 family of proteins Bcl-2 and Bcl-xl in oxidatively challenged human RPE cells (Mukherjee et al., 2004) and promotes cytoprotection.”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Mukherjee et al., 2004
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Essential fatty acids in health and chronic disease
Simopoulos, A. P. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.3.560s · Cited by 1,703
Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189
Self-citationHong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000
Self-citationMechanisms of action of docosahexaenoic acid in the nervous system
Salem, N., Litman, B., Kim, H., & Gawrisch, K. (2001) · Lipids · doi:10.1007/s11745-001-0805-6 · Cited by 919
Neuringer, M. D., CONNOR, W. E., Lin, D. S., Barstad, L., & Luck, S. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.11.4021 · Cited by 914
Effects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
Bazán, N. G. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90086-x · Cited by 855
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802
Self-citationDietary omega-3 fatty acid deficiency and visual loss in infant rhesus monkeys.
Neuringer, M., CONNOR, W. E., Petten, C. V., & Barstad, L. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111202 · Cited by 645
Birch, E. E., Garfield, S., Hoffman, D. R., Uauy, R. D., & Birch, D. G. (2000) · Developmental Medicine & Child Neurology · doi:10.1017/s0012162200000311 · Cited by 619
Effect of Dietary Omega-3 Fatty Acids on Retinal Function of Very-Low-Birth-Weight Neonates
Uauy, R. D., Birch, D. G., Birch, E. E., Tyson, J. E., & Hoffman, D. R. (1990) · Pediatric Research · doi:10.1203/00006450-199011000-00014 · Cited by 574
Research works printed but not linked: 10
- Bazan, N. G. (1990) in Nutrition and the Brain, eds. Wurtman, R. J. & Wurtman, J. J. (Raven, New York), Vol. 8, pp. 1-24.
- Aveldaño di Caldironi, M. I. & Bazan, N. G. (1977) Adv. Exp. Med. Biol. 83, 249-256.411344
- Organisciak, D. T., Darrow, R. M., Jiang, Y. L. & Blanks, J. C. (1996) Invest. Ophthalmol. Vis. Sci. 37, 2243-2257.8843911
- Anderson, R. E, Maude, M. B. & Bok, D. (2001) Invest. Ophthalmol. Vis. Sci. 42, 1715-1720.11431433
- Bicknell, I. R., Darrow, R., Barsalou, L., Fliesler, S. J. & Organisciak, D. T. (2002) Mol. Vis. 8, 333-340.12355060
- Anderson, R. E, Maude, M. B., McClellan, M., Matthes, M. T., Yasumura, D. & LaVail, M. M. (2002) Mol. Vis. 8, 351-358.12355064
- Hu, J. & Bok, D. (2001) Mol. Vis. 7, 14-19.11182021
- Osborne, N. N., Cazevieillem C., Pergandem, G. & Wood, J. P. (1997) Invest. Ophthalmol. Vis. Sci. 38, 1390-1400.9191602
- Liang, Y. G., Jorgensen, A. G., Kaestel, C. G., Wiencke, A. K., Lui, G. M., la Cour, M. H., Ropke, C. H. & Nissen, M. H. (2000) Curr. Eye Res. 20, 25-34.10611712
- Sparrow, J. R. & Cai, B. (2001) Invest. Ophthalmol. Vis. Sci. 42, 1356-1362.11328751
Cited by
Sorted by citations
Items 501–600 of 750
Michael-Titus, A. T. (2009) · Clinical Lipidology · doi:10.2217/clp.09.19 · Cited by 15
Omega-3 Polyunsaturated Fatty Acids for the Treatment of IgA Nephropathy
Hirahashi, J. (2017) · Journal of Clinical Medicine · doi:10.3390/jcm6070070 · Cited by 15
“Inflammatory responses can be self‐limiting by triggering the production of a superfamily of chemical mediators called specialized pro‐resolving mediators (SPMs), which include endogenous mediators of the n‐3‐derived families such as resolvins [28], protectins [29], and maresins [30], as well as arachidonic acid‐deriv…”
How Can Artificial Lipid Models Mimic the Complexity of Molecule–Membrane Interactions?
Rosilio, V. (2018) · Advances in biomembranes and lipid self-assembly · doi:10.1016/bs.abl.2017.12.004 · Cited by 15
Tachikawa, M., Akanuma, S., Imai, T., Okayasu, S., Tomohiro, T., Hatanaka, Y., & Hosoya, K. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00185 · Cited by 15
[The essential fatty acids omega-6 and omega-3: from their discovery to their use in therapy].
Caramia, G. (2008) · PubMed · Cited by 15
Mane, S., Kumari, P., Singh, A., Taneja, N. K., & Chopra, R. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2124505 · Cited by 16
“…DHA forms (RvDs) D-series Resolvins, Maresins (MaRs) oxygenated by enzymes, and neuroprotectins/Protectins (NPDs/PDs) (Ward 2015; Isobe et al. 2013; Dalli et al. 2013; Serhan et al. 2006; Arita et al. 2005; Mukherjee et al. 2004; Marcheselli et al. 2003; Serhan et al. 2002; Serhan et al. 2000).”
Gordon, W. C., Kautzmann, M.-A. I., Jun, B., Cothern, M. L., Fang, Z., & Bazan, N. G. (2023) · Experimental Eye Research · doi:10.1016/j.exer.2023.109639 · Cited by 14
Self-citationSammons, E. L., Buck, G. A. N., Bowman, L. J., Stevens, W. M., Hammami, I., Parish, S., Armitage, J., Sammons, E. L., Bowman, L. J., Stevens, W., et al. (2023) · Ophthalmology · doi:10.1016/j.ophtha.2023.11.030 · Cited by 16
Brücher, B. L. D. M., & Jamall, I. S. (2019) · 4open · doi:10.1051/fopen/2018008 · Cited by 15
Lipid Mediators in Inflammation
Bennett, M., & Gilroy, D. W. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch19 · Cited by 15
Ali, E., & Sonpol, H. M. A. (2016) · The Anatomical Record · doi:10.1002/ar.23536 · Cited by 15
“Non-esterified DHA is the substrate for a 15-lipoxygenase-like enzyme to produce NPD1 (Serhan et al., 2002; Hong et al., 2003).”
Berg, R. W. V., Davidsson, J., Lidin, E., Angéria, M., Risling, M., & Günther, M. (2019) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2019.03.032 · Cited by 14
Potential for daily supplementation of n-3 fatty acids to reverse symptoms of dry eye in mice
Harauma, A., Saito, J., Watanabe, Y., & Moriguchi, T. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.02.005 · Cited by 14
“Also, neuroprotectin D1 derived from DHA protects the retinal pigment epithelial cells from oxidative stress-induced apoptosis and inhibits IL-1βstimulated expression of a promoter transfected into those cells [9], and ocular instillation of resolvin E1 derived from eicosapentaenoic acid (EPA, 20:5n-3) decreases infla…”
Tabilo, C., Squella, V., Illesca, P., Muñoz, Y., Farías, C., & Valenzuela, R. (2025) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2025.102686 · Cited by 15
Bielach-Bazyluk, A., Jakubowicz-Zalewska, O., Myśliwiec, H., & Flisiak, I. (2025) · Antioxidants · doi:10.3390/antiox15010009 · Cited by 15
“Outside the nervous system, PD1 functions as an im-munoresolvent, limiting cytokine release, reducing neutrophil infiltration, and promoting macrophage-mediated clearance [127].”
InfluentialSwinkels, D., Kocherlakota, S., Das, Y., Dane, A. D., Wever, E. J. M., Vaz, F. M., Bazan, N. G., Veldhoven, P. P. V., & Baes, M. I. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.14.10 · Cited by 14
“2,4,51,52 On the one hand, it has been shown that, under uncompensated oxidative stress, RPE cells convert DHA to the protective lipid mediators neuroprotectin D1 (NPD1), resolvins, protectins, and maresins.”
Zia, B., Elmeky, M., Azimullah, S., Jha, N. K., Meeran, M. F. N., & Ojha, S. K. (2025) · Current Neuropharmacology · doi:10.2174/011570159x365720250225080257 · Cited by 13
“These properties make NPD1 a promising mediator for treating neurodegenerative diseases, acute neurological injuries, and chronic pain syndromes by leveraging its anti-inflammatory and neuroprotective effects [2, 32].”
InfluentialKanan, Y., Gordon, W. C., Mukherjee, P. K., Bazan, N. G., & Al‐Ubaidi, M. R. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0111-4 · Cited by 17
“…conditions of uncompensated oxidative stress, DHA is released from the phospholipids and converted by 15-lipoxygenase-1 (15-LOX-1) into neuroprotectin D1 (NPD1) (Mukherjee et al. 2004, 2007a), a highly potent, selective mediator that initiates anti-inflammatory, pro-survival signaling (Bazan 2007).”
InfluentialIonescu, N., de Freitas, C., & Bueno, A. A. (2013) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-013-0327-y · Cited by 13
Jin, J., Boeglin, W. E., & BRASH, A. R. (2021) · Journal of Lipid Research · doi:10.1016/j.jlr.2021.100088 · Cited by 15
“Although detection of PD1 (aka neuroprotectin D1 [NPD1]) first appeared in 2004 (48, 49) and included analyses proposing a mechanism of biosynthesis and chemical structure (50), the very existence of PD1 (same as NPD1) as a significant biosynthetic product is not achieved with the level of certainty afforded to LTB4.”
SanGiovanni, J. P., Mehta, S., & Mehta, S. (2008) · World review of nutrition and dietetics · doi:10.1159/000193002 · Cited by 13
Liu, A., Lin, Y., Terry, R., Nelson, K., & Bernstein, P. S. (2011) · Clinical Lipidology · doi:10.2217/clp.11.41 · Cited by 14
Neuroinflammation and Proteostasis are Modulated by Endogenously Biosynthesized Neuroprotectin D1
Bazan, N. G. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8322-5 · Cited by 13
“Endogenous NPD1 biosynthesis is promptly induced in response to oxidative stress [17, 18], protein misfolding/ proteotoxicity [19], seizures [20], brain ischemia reperfusion [16, 21], and by neurotrophins [22].”
Uauy, R. D. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507832892 · Cited by 13
Shaw, L. C., Calzi, S. L., Li, N., Moldovan, L., Sengupta, N., Quigley, J., Ivan, M., Jun, B., Bazan, N. G., Boulton, M. E., et al. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-23034 · Cited by 12
Hamidzadeh, K., Westcott, J., Wourms, N., Shay, A. E., Panigrahy, A., Martin, M. J., Nshimiyimana, R., & Serhan, C. N. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115181 · Cited by 12
Antioxidants Improve the Viability of Stored Adult Retinal Pigment Epithelial-19 Cultures
Pasovic, L., Eidet, J. R., Lyberg, T., Messelt, E. B., Aabel, P., & Utheim, T. P. (2014) · Ophthalmology and Therapy · doi:10.1007/s40123-014-0024-9 · Cited by 14
“The addition of DHA to ARPE-19 cell cultures has an inhibitory effect on cellular oxidative stress [22, 41], specifically by upregulating antiapoptotic proteins and down-regulating proapoptotic proteins [23].”
Kwa, F. A. A., Dulull, N. K., Roessner, U., Dias, D. A., & Rupasinghe, T. (2020) · F1000Research · doi:10.12688/f1000research.19598.5 · Cited by 10
Cell Biology of the Retinal Pigment Epithelium
Thumann, G., Dou, G., Wang, Y., & Hinton, D. R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00016-3 · Cited by 12
García, P. P., Martínez, F. J. H., López, N. A., Torre, L. J. C., & Sempere, M. E. T. (2022) · Antioxidants · doi:10.3390/antiox11010116 · Cited by 14
Specialized pro‐resolving mediators: wiring the circuitry of effector immune and tissue homeostasis
Fredman, G., & Serhan, C. N. (2011) · Endodontic Topics · doi:10.1111/etp.12010 · Cited by 12
Lipid Mediator Informatics-Lipidomics: Novel Pathways in Mapping Resolution
Serhan, C. N., Hong, S., & Lu, Y. (2006) · The AAPS Journal · doi:10.1208/aapsj080233 · Cited by 12
The biosynthetic pathways of the protectins
Haatveit, Å. S., & Hansen, T. V. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106787 · Cited by 12
Lipoxins, resolvins and protectins: new leads for the treatment of asthma
Haworth, O., & Levy, B. D. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.10.1209 · Cited by 11
“Microglia Inhibits IL-1 β release Mouse [57,58]”
Ácido docosahexaenoico (DHA), un ácido graso esencial a nivel cerebral
Rodrigo Valenzuela, B., Jessica Morales, P., Julio Sanhueza, C., & Alfonso Valenzuela, B. (2013) · Revista chilena de nutrición · doi:10.4067/s0717-75182013000400009 · Cited by 12
Cubizolle, A., Guillou, L., Mollereau, B., Hamel, C., & Brabet, P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180148 · Cited by 12
Langbøl, M. A., Saruhanian, S., Baskaran, T., Tiedemann, D., Mouhammad, Z. A., Toft‐Kehler, A. K., Jun, B., Vohra, R., Bazan, N. G., & Kolko, M. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092979 · Cited by 11
Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?
Satkunendrarajah, K., & Fehlings, M. G. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.08.008 · Cited by 11
Lu, Y., Tian, H., Peng, H., Wang, Q., Bunnell, B. A., Bazan, N. G., & Hong, S. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1380059 · Cited by 10
Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis
Lagarde, M., Liu, M., Véricel, E., Calzada, C., Chen, P., Driss, F., & Guichardant, M. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113003704 · Cited by 10
“In this case, the biosynthetic route seems to mimic leukotriene B4 production by 5-LOX from ARA, then leading to 10(R), 17(S)diOH-4Z,7Z,11E,13E,15Z,19Z−22 :6((23,24)).”
Local shifts in inflammatory and resolving lipid mediators in response to tendon overuse
Markworth, J. F., Sugg, K. B., Sarver, D. C., Maddipati, K. R., & Brooks, S. V. (2021) · The FASEB Journal · doi:10.1096/fj.202100078r · Cited by 11
Calandria, J. M., Do, K. V., Kala-Bhattacharjee, S., Obenaus, A., Belayev, L., & Bazan, N. G. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01231-6 · Cited by 10
Is Alzheimer's Disease a Synaptic Disorder?
Pomponi, M., Bria, P., & Pomponi, M. F. L. (2008) · Journal of Alzheimer s Disease · doi:10.3233/jad-2008-13104 · Cited by 10
“The new series of endogenous mediators NPD1 and RvD in the blood, leukocytic, brain, and glial cells were discovered a few years ago, while studying mice undergoing experimental strokes [26,95,96].”
Moodley, T., Vella, C., Djahanbakhch, O., Branford-White, C. J., & Crawford, M. A. (2009) · Nutrition and Health · doi:10.1177/026010600902000206 · Cited by 10
IN VITRO ANTIOXIDANT AND ANTI INFLAMMATORY ACTIVITY OF COCCINIA GRANDIS
Lather, N., Bole, S., Ab, V., & Balu, S. (2012) · Cited by 10
Deng, Q., Wang, Y., Wang, C., Ji, B., Cong, R., Zhao, L., Chen, P., Zang, X., Lu, F. L., Han, F., et al. (2018) · Food & Function · doi:10.1039/c7fo01168g · Cited by 11
Choline and Ethanolamine Glycerophospholipids
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2009) · Springer eBooks · doi:10.1007/978-0-387-30378-9_2 · Cited by 11
Marchioli, R., & Levantesi, G. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.06.041 · Cited by 9
“of n-3 PUFAs [29,42,85–104] might improve the clinical natural course of the disease.”
Effect of Docosahexaenoic Acid (DHA) on Spinal Cord Injury
Samaddar, S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_2 · Cited by 9
Dhingra, A., Sharp, R. C., Kim, T., Popov, A. V., Ying, G., Pietrofesa, R. A., Park, K., Christofidou‐Solomidou, M., & Boesze‐Battaglia, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115764 · Cited by 9
“RPE and RPE-LC3B cells were treated with H2O2 (200 μM or 600 μM) and 10 ng/mL TNF-α to induce oxidative stress, as described previously [47,48].”
InfluentialMaskrey, B. H., Taylor, G. W., & Rowley, A. F. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02037 · Cited by 9
“Recent studies have shown that in mammals these alternative fatty acids can act as substrates for the biosynthesis of a range of novel compounds including the resolvins and neuroprotectins whose discovery goes some way to explain the beneficial effects of fish oils rich in these omega-3 fatty acids (Marcheselli et al.…”
Molecular Neurobiology of Retinal Degeneration
Sharma, R. (2007) · Springer eBooks · doi:10.1007/978-0-387-30374-1_3 · Cited by 9
Diet and Supplements in the Prevention and Treatment of Eye Diseases
Mares, J. A., Millen, A. E., Lawler, T. P., & Blomme, C. K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802928-2.00019-9 · Cited by 9
Lipid differences in rod outer segment membranes of rats with P23H and S334ter opsin mutations.
Martin, R. E., Fliesler, S. J., Brush, R. S., Richards, M. J., Hopkins, S. A., & Anderson, R. E. (2005) · PubMed · Cited by 9
Hill, K. A. J. (2009) · St Andrews Research Repository (St Andrews Research Repository) · Cited by 9
Pham, T. L., He, J., Kakazu, A. H., Calandria, J. M., Do, K. V., Nshimiyimana, R., Petasis, N. A., Bazán, H. E. P., & Bazan, N. G. (2020) · doi:10.21203/rs.3.rs-55764/v1 · Cited by 9
Biology and Total Synthesis of n-3 Docosapentaenoic Acid-Derived Specialized Pro-Resolving Mediators
Reinertsen, A. F., Vik, A., & Hansen, T. V. (2024) · Molecules · doi:10.3390/molecules29122833 · Cited by 8
“In addition, Dalli, Chiang, and Serhan reported investigations of the transcellularly biosynthesis using n-3 Hence, these 12 SPMs are congeners of the DHA-derived SPMs. ( 3 ) and COX-2 during neutrophil–endothelial cell interactions.”
Hachem, M. (2021) · Biochimie · doi:10.1016/j.biochi.2021.02.012 · Cited by 8
Essential Fatty Acids—Biochemistry, Physiology and Clinical Significance
Das, U. N. (2011) · Springer eBooks · doi:10.1007/978-94-007-0495-4_4 · Cited by 9
Nutritional factors in human dispersals
Rotilio, G., & Marchese, E. (2010) · Annals of Human Biology · doi:10.3109/03014461003649289 · Cited by 8
“…the metabolism of docosohexanoic acid in neuroectodermic cells of the retinal pigment epithelium gives rise to molecules with potent neuroprotective activity, promoting cell survival under conditions of oxidative stress, a current challenge to the central nervous system (Mukherjee et al. 2004).”
Fan, C., Sun, W., Fu, H., Dong, H., Xia, L., Lu, Y., Deckelbaum, R. J., & Qi, K. (2015) · PubMed · doi:10.3305/nh.2015.32.3.9259 · Cited by 8
Total Syntheses of Two bis‐Allylic‐Deuterated DHA Analogues
Rosell, M., Villa, M., Durand, T., Galano, J., Vercauteren, J., & Crauste, C. (2017) · Asian Journal of Organic Chemistry · doi:10.1002/ajoc.201600565 · Cited by 8
Li, Y., Bang, S., Ji, J., xu, J., Lee, M., Chandra, S., Serhan, C. N., & Ji, R. (2026) · Journal of Clinical Investigation · doi:10.1172/jci190754 · Cited by 10
Waltrick, A. P. F., Radulski, D. R., de Oliveira, K. M., Acco, A., Verri, W. A., Jr., da Cunha, J. M., & Zanoveli, J. M. (2024) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2024.111028 · Cited by 7
Guiné, R. P. F., & Henriques, F. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 7
Roles of Docosahexaenoic and Eicosapentaenoic Acids in Brain
Farooqui, A. A. (2009) · Springer eBooks · doi:10.1007/978-1-4419-0543-7_5 · Cited by 8
Albumin Infusion Therapy in Stroke, Sepsis and the Critically Ill
Das, U. N. (2008) · Current Nutrition & Food Science · doi:10.2174/157340108785133329 · Cited by 7
“NPD1 inhibited oxidative stress-induced apoptosis of human retinal pigment epithelial cells [62].”
Pasovic, L., Utheim, T. P., Reppe, S., Khan, A. Z., Jackson, C. J., Thiede, B., Berg, J. P., Messelt, E. B., & Eidet, J. R. (2018) · Scientific Reports · doi:10.1038/s41598-018-24121-8 · Cited by 7
Change in phospholipid species of retinal layer in traumatic optic neuropathy model
Hirahara, Y., Wakabayashi, T., Koike, T., Gamo, K., & Yamada, H. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24500 · Cited by 7
“DHA is also used as a signal transduction molecule, which pro‐ tects from neuronal damages in oxidative injuries to the retina (Mukherjee et al., 2004).”
Enzymatic studies with 3-oxa n-3 DPA
Pangopoulos, M. K., Nolsøe, J. M. J., Antonsen, S. G., Colas, R. A., Dalli, J., Aursnes, M., Stenstrøm, Y., & Hansen, T. V. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.103653 · Cited by 7
Pilkington, S. M., & Rhodes, L. E. (2010) · Springer eBooks · doi:10.1007/978-3-642-12264-4_9 · Cited by 7
Reinoso, M. A., Mukherjee, P. K., Marcheselli, V., Bergsma, D. R., Hesse, R. J., & Bazan, N. G. (2008) · PubMed Central · Cited by 6
Resolvins, protectins and other lipid mediators in obesity-associated inflammatory disorders
Clària, J., Titos, E., López‐Vicario, C., & González‐Périz, A. (2010) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2010.10.002 · Cited by 8
Hansen, T. V., Dalli, J., & Serhan, C. N. (2016) · RSC Advances · doi:10.1039/c6ra00414h · Cited by 7
Effect of Nicotinic Acid on Fresh Semen Characteristics in Miniature Pigs
Lee, Y., Lee, S., Lee, E., Lee, S. T., Cheong, H.-T., Yang, B.-K., Lee, S., & Park, C. (2014) · Journal of Animal Reproduciton and Biotechnology · doi:10.12750/jet.2014.29.4.385 · Cited by 6
Prevention of Oxidative Stress by Omega-3 Fatty Acids in the Brain
Farooqui, A. A., & Farooqui, T. (2016) · Springer eBooks · doi:10.1007/978-3-319-40458-5_19 · Cited by 7
Understanding the Role of Pro-resolving Lipid Mediators in Infectious Keratitis
Berger, E. A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-21735-8_2 · Cited by 7
Die Rolle neuer „pro-resolving” Lipidmediatoren bei entzündlichen Lungenerkrankungen
Eickmeier, O., Hilberath, J. N., Zielen, S., & Haworth, O. (2010) · Pneumologie · doi:10.1055/s-0030-1255913 · Cited by 7
Wildburger, N. C., Lichti, C. F., LeDuc, R. D., Schmidt, M. E., Kroes, R. A., Moskal, J. R., & Nilsson, C. L. (2015) · EuPA Open Proteomics · doi:10.1016/j.euprot.2015.06.006 · Cited by 6
“DHA is a precursor to many bioactive molecules with antiinflammatory effects [54–58].”
Bermúdez, V., Tenconi, P. E., Giusto, N. M., & Mateos, M. V. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-27378-1_47 · Cited by 5
Kwa, F. A. A., Dulull, N. K., Roessner, U., Dias, D. A., & Rupasinghe, T. (2019) · F1000Research · doi:10.12688/f1000research.19598.2 · Cited by 5
Bazan, N. G., Stark, D. T., & Petasis, N. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374947-5.00036-5 · Cited by 5
The Systems Theory of Autistogenesis
Malone, J. P. (2012) · SAGE Open · doi:10.1177/2158244012444281 · Cited by 7
“Neuroprostanes are generated within the brain through enzyme-independent reactions due to oxidative stress leading to apoptosis (Mukherjee et al., 2004).”
Common Pathways to Neurodegeneration and Co-morbid Depression
Litteljohn, D., Mangano, E. N., & Hayley, S. P. (2010) · Springer eBooks · doi:10.1007/978-90-481-8553-5_8 · Cited by 5
“, up-regulate anti-apoptotic Bcl-2 protein expression, down-regulate COX-2 expression) [414–416].”
Satija, S., Mitchell, T. W., Anthony, R., Peoples, G. E., & Sampson, J. A. (2025) · Sports Medicine · doi:10.1007/s40279-025-02347-7 · Cited by 5
“The final steps involve specific structural rearrangements facilitated by epoxide hydrolases and dehydrogenase enzymes, resulting in the formation of protectin D1 [91, 92].”
Lipoxin A4 (LXA4) as a Potential Drug for Diabetic Retinopathy
Das, U. N. (2025) · Medicina · doi:10.3390/medicina61020177 · Cited by 4
Yang, L., Xu, Z., Wang, Y., Wen, S., Shi, Y., Qu, J., Lü, F., & Hu, L. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70552 · Cited by 4
Bazan, N. G., & Asatryan, A. (2011) · Oléagineux Corps gras Lipides · doi:10.1051/ocl.2011.0403 · Cited by 4
“Potent protective bioactivity of NPD1 was shown in various models of neuroinflammatory pathology, including age-related macular degeneration [AMD] (Bazan, 2006, Bazan, 2007; Mukherjee et al., 2004), stroke (Bazan, 2003; d’Abramo et al.”
InfluentialEndogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease
Serhan, C. N., & Godson, C. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-380928-5.10004-1 · Cited by 5
DHA A Key Supplement for Neurologic Health—An Insight
Suvarna, V., & Singh, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815238-6.00026-2 · Cited by 4
Thaler, S., Haritoglou, C., & Schuettauf, F. (2013) · Der Ophthalmologe · doi:10.1007/s00347-013-2831-0 · Cited by 4
Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis
Bahrami, G., Sajadimajd, S., & Khosravifar, M. (2021) · Current Molecular Pharmacology · doi:10.2174/1874467214666210902121337 · Cited by 4
The Use of n-3 Polyunsaturated Fatty Acids as Therapeutic Agents for Inflammatory Diseases
Calder, P. C. (2009) · Immunology Endocrine & Metabolic Agents - Medicinal Chemistry · doi:10.2174/187152209788009788 · Cited by 4
Docosahexaenoic Acid (DHA), in the Prevention and Treatment of Neurodegenerative Diseases
Valenzuela, R., & Valenzuela, A. (2011) · InTech eBooks · doi:10.5772/28000 · Cited by 4
“It was the discovery of a number of bioactive compounds derived from DHA, called protectins and resolvins, which show cytoprotective properties that open the way to a better understanding of how DHA may exert at the molecular level its neuroprotective actions (Mukherjee et al., 2004).”
Beneficial Effects of Docosahexaenoic Acid on Health of the Human Brain
Farooqui, A. A. (2008) · Springer eBooks · doi:10.1007/978-0-387-09693-3_8 · Cited by 4
The stress-myopia pathway: A pivotal hub in myopia pathogenesis
Li, Y., Tan, Z., & Duan, J. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106668 · Cited by 3
Biosynthesis and analytics of specialized pro-resolving mediators: facts and faults
Schebb, N. H., Kühn, H., Kampschulte, N., Flamand, N., Peters-Golden, M. L., Jakobsson, P., Claesson, H., Weylandt, K. H., Rohwer, N., Saul, M. J., et al. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101133 · Cited by 5
“The structure was deduced based on UV and LC-MS analyses both as a product or by-product of soybean LOX activity (albeit going against all precedent and not independently confirmed) (120), and reported as a product of biosynthesis in mammalian cells (121, 122).”
Ervik, K., Li, Y., Ji, R., Serhan, C. N., & Hansen, T. V. (2024) · Organic & Biomolecular Chemistry · doi:10.1039/d4ob01534g · Cited by 4
Possible Mechanisms of Neural Injury Caused by Glutamate and Its Receptors
Farooqui, A. A., Ong, W., & Horrocks, L. A. (2007) · Springer eBooks · doi:10.1007/978-0-387-73023-3_7 · Cited by 3
Diet and Supplements in the Prevention and Treatment of Eye Diseases
Mares, J. A., Millen, A. E., & Meyers, K. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00019-6 · Cited by 3
Metadata
- Authors
- Mukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Bazan, Nicolas G.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2004-05-19
- Volume
- 101
- Issue
- 22
- Pages
- 8491-8496
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC420421
- OpenAlex
- W1739691545
- Cited by
- 753
- References
- 50
- Citations by year
- 2026: 22 · 2025: 14 · 2024: 13 · 2023: 14 · 2022: 24 · 2021: 20 · 2020: 34 · 2019: 23 · 2018: 25 · 2017: 34 · 2016: 24 · 2015: 35 · 2014: 42 · 2013: 52 · 2012: 42
- FWCI
- 44.10
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Huntsman Cancer Institute
- University of Leicester
- National Institutes of Health (4r37gm038765-19, GM 38765)
- National Eye Institute (EY05121, R01EY005121)
- National Institute of General Medical Sciences (GM 38765, R01GM038765, R37-GM038765)
- National Center for Research Resources (P20RR-16816, P20RR016816)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- neuroprotectin D1, docosahexaenoic acid, retinal pigment epithelium, oxidative stress, apoptosis, phospholipase A2, cyclooxygenase-2, Bcl-2 family proteins, caspase-3, IL-1β, photoreceptor survival, retinal degeneration, lipid mediators
- MeSH terms
- Cell Line, Docosahexaenoic Acids, Epithelial Cells, Humans, Interleukin-1, Isoenzymes, Membrane Proteins, Pigment Epithelium of Eye, Prostaglandin-Endoperoxide Synthases, Lipid Peroxidation, Molecular Structure, Apoptosis, Oxidative Stress, Proto-Oncogene Proteins c-bcl-2, Caspases, Cyclooxygenase 2, Caspase 3, DNA Fragmentation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
