Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
Open accessAbstract
Ischemic stroke triggers lipid peroxidation and neuronal injury. Docosahexaenoic acid released from membrane phospholipids during brain ischemia is a major source of lipid peroxides. Leukocyte infiltration and pro-inflammatory gene expression also contribute to stroke damage. In this study using lipidomic analysis, we have identified stereospecific messengers from docosahexaenoate-oxygenation pathways in a mouse stroke model. Aspirin, widely used to prevent cerebrovascular disease, activates an additional pathway, which includes the 17R-resolvins. The newly discovered brain messenger 10,17S-docosatriene potently inhibited leukocyte infiltration, NFkappaB, and cyclooxygenase-2 induction in experimental stroke and elicited neuroprotection. In addition, in neural cells in culture, this lipid messenger also inhibited both interleukin 1-beta-induced NFkappaB activation and cyclooxygenase-2 expression. Thus, the specific novel bioactive docosanoids generated in vivo counteract leukocyte-mediated injury as well as pro-inflammatory gene induction. These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion.
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sAPPα may activate NPD1 biosynthetic enzymes PLA2 and/or a 15-LOX-like enzyme integral to NPD1 biosynthesis.
“sAPPα may activate NPD1 biosynthetic enzymes PLA2 and/or a 15-LOX– like enzyme integral to NPD1 biosynthesis (Calandria et al., 2009; Marcheselli et al., 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Marcheselli et al., 2003
In mouse brain undergoing ischemia/reperfusion, NPD1 increases during the initial 8 hours after 1 h of ischemia.
“In mouse brain undergoing ischemia/reperfusion, NPD1 increases during the initial 8 hours after 1 h of ischemia (Marcheselli et al., 2003).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Marcheselli et al., 2003
NPD1 is a neuroprotective mediator in ischemic stroke, as defined by cellular and molecular targets.
“NPD1 is highlighted here as a neuroprotective mediator in ischemic stroke, as defined by cellular and molecular targets, and demonstrated that the pathway that leads to its formation was enhanced in its neuroprotective bioactivity by the presence of aspirin (Marcheselli et al., 2003) by aspirin-triggered NPD1 (Bazan et al., 2012; Serhan et al., 2015; Serhan and Petasis, 2011).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Marcheselli et al., 2003
Aspirin enhances the neuroprotective bioactivity of the pathway leading to NPD1 formation.
“NPD1 is highlighted here as a neuroprotective mediator in ischemic stroke, as defined by cellular and molecular targets, and demonstrated that the pathway that leads to its formation was enhanced in its neuroprotective bioactivity by the presence of aspirin (Marcheselli et al., 2003) by aspirin-triggered NPD1 (Bazan et al., 2012; Serhan et al., 2015; Serhan and Petasis, 2011).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Marcheselli et al., 2003
NPD1 attenuates damage resulting from ischemia-reperfusion.
“The stereoselective mediator neuroprotectin D1 (NPD1; 10R,17S-dihydroxy-docosa-4Z,7Z,11E,13E,15Z,19Z-hexaenoic acid) has been shown to attenuate damage resulting from ischemia-reperfusion [19].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [19]
NPD1 could downregulate cyclooxygenase-2 expression during epileptogenesis and limit neuroinflammatory-mediated damage.
“In addition, it could downregulate cyclooxgenase-2 expression during epileptogenesis [58] and limit neuroinflammatory-mediated damage [19, 56].”
From Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1 (2015) · cites this paper as [19]
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Cites
Handbook of Parametric and Nonparametric Statistical Procedures
(2004) · Technometrics · doi:10.1198/tech.2004.s209 · Cited by 4,664 · see citing works
Bederson, J. B., Pitts, L. H., Tsuji, M., Nishimura, M. C., Davis, R. L., & Bartkowski, H. (1986) · Stroke · doi:10.1161/01.str.17.3.472 · Cited by 2,681 · see citing works
Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., & Moussignac, R.-L. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020760 · Cited by 1,650 · see citing works
Self-citationSerhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189 · see citing works
Self-citationHong, S., Gronert, K., Devchand, P. R., Moussignac, R.-L., & Serhan, C. N. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300218200 · Cited by 1,000 · see citing works
Self-citationEffects of ischemia and electroconvulsive shock on free fatty acid pool in the brain
Bazán, N. G. (1970) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(70)90086-x · Cited by 855 · see citing works
Interleukin 1 in the brain: biology, pathology and therapeutic target
Rothwell, N. J. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01661-1 · Cited by 671 · see citing works
NF-κB is activated and promotes cell death in focal cerebral ischemia
Schneider, A., Martín-Villalba, A., Weih, F., Vogel, J., Wirth, T., & Schwaninger, M. (1999) · Nature Medicine · doi:10.1038/8432 · Cited by 642 · see citing works
Handbook of Parametric and Nonparametric Statistical Procedures
Nash, M. S. (2001) · Technometrics · doi:10.1198/tech.2001.s629 · Cited by 572 · see citing works
Polyunsaturated fatty acids are potent neuroprotectors
Lauritzen, I., Blondeau, N., Heurteaux, C., Widmann, C., Romey, G., & Lazdunski, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.8.1784 · Cited by 493 · see citing works
Matsuo, Y., Onodera, H., Shiga, Y., Nakamura, M., Ninomiya, M., Kihara, T., & Kogure, K. (1994) · Stroke · doi:10.1161/01.str.25.7.1469 · Cited by 485 · see citing works
Roles of Nuclear Factor κB in Neuronal Survival and Plasticity
Mattson, M. P., Culmsee, C., Yu, Z., & Camandola, S. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740443.x · Cited by 449 · see citing works
Membrane docosahexaenoate is supplied to the developing brain and retina by the liver.
Scott, B. L., & Bazan, N. (1989) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.86.8.2903 · Cited by 445 · see citing works
Self-citationZhang, R., Brennan, M.-L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., & Hazen, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209124200 · Cited by 432 · see citing works
Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid*
Roberts, L., Montine, T., Markesbery, W., Tapper, A. R., Hardy, P., Chemtob, S., Dettbarn, W., & Morrow, J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.22.13605 · Cited by 430 · see citing works
Mitochondria, free radicals, and neurodegeneration
Beal, M. F. (1996) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(96)80100-0 · Cited by 422 · see citing works
Cerebrovascular Disease: Pathophysiology, Diagnosis and Management
Ginsberg, M. D., & Bogousslavsky, J. (1998) · Medical Entomology and Zoology · Cited by 392 · see citing works
Handbook of parametric and nonparametric statistical procedures, 2nd ed.
Sheskin, D. J. (2000) · Cited by 354 · see citing works
Moskowitz, M. A., Kiwak, K. J., Hekimian, K., et al. (1984) · Science · doi:10.1126/science.6719118 · Cited by 352 · see citing works
Inhibition of Neuronal Apoptosis by Docosahexaenoic Acid (22:6n-3)
Kim, H., Akbar, M. D., Lau, A. O. T., & Edsall, L. C. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004446200 · Cited by 308 · see citing works
Gamoh, S., Hashimoto, M., Sugioka, K., Hossain, S., Hata, N., Misawa, Y., & Masumura, S. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00107-4 · Cited by 301 · see citing works
Mabuchi, T., Kitagawa, K., Ohtsuki, T., Kuwabara, K., Yagita, Y., Yanagihara, T., Hori, M., & Matsumoto, M. (2000) · Stroke · doi:10.1161/01.str.31.7.1735 · Cited by 280 · see citing works
McGahon, B., Martin, D. S. D., Horrobin, D. F., & Lynch, M. A. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00219-5 · Cited by 221 · see citing works
Chatzipanteli, K., Alonso, O. F., Kraydieh, S., & Dietrich, W. D. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00012 · Cited by 193 · see citing works
Chopp, M., Li, Y., Jiang, N., Zhang, R. L., & Prostak, J. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199607000-00007 · Cited by 185 · see citing works
Lukiw, W. J., & Bazan, N. G. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980901)53:5 · Cited by 183 · see citing works
Self-citationPostischemic Cerebrovascular E-Selectin Expression Mediates Tissue Injury in Murine Stroke
Huang, J., Choudhri, T. F., Winfree, C. J., McTaggart, R., Kiss, S., Mocco, J., Kim, L. J., Protopsaltis, T. S., Zhang, Y., Pinsky, D. J., et al. (2000) · Stroke · doi:10.1161/01.str.31.12.3047 · Cited by 172 · see citing works
Protein Kinase Inhibition by ω-3 Fatty Acids
Mirnikjoo, B., Brown, S. E., Kim, H. F. S., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008150200 · Cited by 166 · see citing works
Docosahexaenoic acid (22:6, n-3) is metabolized to lipoxygenase reaction products in the retina
Bazan, N. G., Birkle, D. L., & Reddy, T. S. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(84)90601-6 · Cited by 107 · see citing works
Self-citationBazan, N. G., & Lukiw, W. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203201200 · Cited by 102 · see citing works
Self-citationDocosahexaenoic acid utilization during rod photoreceptor cell renewal
Gordon, W., & Bazan, N. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-07-02190.1990 · Cited by 101 · see citing works
Self-citationTurco, E., Belayev, L., Liu, Y., et al. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01121.x · Cited by 96 · see citing works
̃o, M. I. A., & ́n, N. ́. G. B. (1975) · Brain Research · doi:10.1016/0006-8993(75)90244-9 · Cited by 85 · see citing works
Transcellular Regulation of Eicosanoid Biosynthesis
Gronert, K., Clish, C. B., Romano, M., & Serhan, C. N. (2003) · Humana Press eBooks · doi:10.1385/1-59259-263-5:119 · Cited by 54 · see citing works
Self-citationGaudet, R. J., & Levine, L. (1980) · Stroke · doi:10.1161/01.str.11.6.648 · Cited by 53 · see citing works
Kinetics of polymorphonuclear neutrophil infiltration after a traumatic brain injury in rat
Royo, N. C., Wahl, F., & Stutzmann, J. M. (1999) · Neuroreport · doi:10.1097/00001756-199904260-00038 · Cited by 51 · see citing works
Free fatty acids and energy metabolites in ischemic cerebral cortex with noradrenaline depletion
Yoshida, S., Harik, S. I., Busto, R., Santiso, M., Martinez, E., & Ginsberg, M. D. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb02741.x · Cited by 46 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Bazan, N. G., and Allan, G. (1998) in Cerebrovascular Disease: Pathophysiol- ogy, Diagnosis, and Management (Ginsberg, M. D., and Bogousslavsky, J., eds) pp. 532-555, Blackwell Science, Inc., Malden, MA
- Bazan, N. G. (1990) in Nutrition and the Brain (Wurtman, R. J., and Wurtman, J. J., eds) Vol. 8, pp. 1-24, Raven Press, Ltd., New York
- Scott, B. L., and Bazan, N. G. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 2903-2907
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Serhan, C. N. (2014) · Nature · doi:10.1038/nature13479 · Cited by 3,041 · see citing works
Self-citationResolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932 · see citing works
Self-citationResolution of inflammation: the beginning programs the end
Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works
Self-citationn−3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases
Calder, P. C. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1505s · Cited by 2,525 · see citing works
The Opposing Effects of N-3 and n-6 Fatty Acids
Schmitz, G., & Ecker, J. (2008) · Progress in Lipid Research · doi:10.1016/j.plipres.2007.12.004 · Cited by 1,245 · see citing works
Resolvins and protectins in inflammation resolution
Serhan, C. N., & Petasis, N. A. (2011) · Chemical Reviews · doi:10.1021/cr100396c · Cited by 996 · see citing works
Self-citationMukherjee, P. K., Marcheselli, V. L., Serhan, C. N., & Bazan, N. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402531101 · Cited by 753 · see citing works
Polyunsaturated fatty acids and inflammatory processes: New twists in an old tale
Calder, P. C. (2009) · Biochimie · doi:10.1016/j.biochi.2009.01.008 · Cited by 721 · see citing works
Essential Fatty Acids: Biochemistry, Physiology and Pathology
Das, U. N. (2006) · Biotechnology Journal · doi:10.1002/biot.200600012 · Cited by 650 · see citing works
Serhan, C. N., Dalli, J., Colas, R. A., Winkler, J. W., & Chiang, N. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.006 · Cited by 492 · see citing works
Modulation of inflammation in brain: A matter of fat
Farooqui, A. A., Horrocks, L. A., & Farooqui, T. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04371.x · Cited by 460 · see citing works
Bazan, N. G., Molina, M. F., & Gordon, W. C. (2011) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104635 · Cited by 441 · see citing works
Self-citationNovel Lipid Mediators and Resolution Mechanisms in Acute Inflammation
Serhan, C. N. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.100322 · Cited by 421 · see citing works
Self-citationLayé, S., Nadjar, A., Joffre, C., & Bazinet, R. P. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014092 · Cited by 420 · see citing works
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Bazan, N. G. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.005 · Cited by 353 · see citing works
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Ross, B. M., Seguin, J., & Sieswerda, L. E. (2007) · Lipids in Health and Disease · doi:10.1186/1476-511x-6-21 · Cited by 275 · see citing works
Bazan, N. G. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800068-jlr200 · Cited by 256 · see citing works
Self-citationBazan, N. G. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r300013-jlr200 · Cited by 247 · see citing works
Self-citationPark, C.-K., Lü, N., Xu, Z.-Z., Liu, T., Serhan, C. N., & Ji, R.-R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2443-11.2011 · Cited by 241 · see citing works
Self-citationHe, C., Qu, X., Cui, L., Wang, J., & Kang, J. X. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904835106 · Cited by 233 · see citing works
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Zhu, M., Wang, X., Hjorth, E., Colas, R. A., Schroeder, L., Granholm, A.-C., Serhan, C. N., & Schultzberg, M. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9544-0 · Cited by 204 · see citing works
Self-citationBelayev, L., Khoutorova, L., Atkins, K. D., & Bazan, N. G. (2009) · Stroke · doi:10.1161/strokeaha.109.555979 · Cited by 170 · see citing works
Self-citationNeurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling
Mukherjee, P. K., Marcheselli, V. L., Barreiro, S., Hu, J., Bok, D., & Bazan, N. G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705949104 · Cited by 170 · see citing works
Self-citationPolyunsaturated fatty acids, neuroinflammation and well being
Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167 · see citing works
de Roos, B., Mavrommatis, Y., & Brouwer, I. A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00189.x · Cited by 151 · see citing works
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148 · see citing works
Self-citationBazan, N. G., Calandria, J. M., & Serhan, C. N. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r001131 · Cited by 140 · see citing works
Bazan, N. G., Musto, A. E., & Knott, E. J. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8200-6 · Cited by 125 · see citing works
Self-citationBazan, N. G., Eady, T. N., Khoutorova, L., Atkins, K. D., Hong, S., Lu, Y., Zhang, C., Jun, B., Obenaus, A., Fredman, G., et al. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.04.007 · Cited by 121 · see citing works
Ferreira, I., Falcato, F., Bandarra, N., & Rauter, A. P. (2022) · Molecules · doi:10.3390/molecules27051677 · Cited by 120 · see citing works
Identification of disease markers in human cerebrospinal fluid using lipidomic and proteomic methods
Fonteh, A. N., Harrington, R. J., Huhmer, A. F., Biringer, R. G., Riggins, J. N., & Harrington, M. G. (2006) · Disease Markers · doi:10.1155/2006/202938 · Cited by 113 · see citing works
Calder, P. C. (2008) · Proceedings of The Nutrition Society · doi:10.1017/s0029665108008690 · Cited by 111 · see citing works
Calandria, J. M., Marcheselli, V. L., Mukherjee, P. K., Uddin, J., Winkler, J. W., Petasis, N. A., & Bazan, N. G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.003988 · Cited by 104 · see citing works
Belayev, L., Hong, S.-H., Menghani, H., Marcell, S. J., Obenaus, A., Freitas, R. S., Khoutorova, L., Balaszczuk, V., Jun, B., Oriá, R. B., et al. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1136-3 · Cited by 103 · see citing works
Self-citationLipid metabolism in Alzheimer’s disease
Liu, Q., & Zhang, J. (2014) · Neuroscience Bulletin · doi:10.1007/s12264-013-1410-3 · Cited by 101 · see citing works
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Li, P., & Song, C. (2022) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1735143 · Cited by 74 · see citing works
Musto, A. E., Gjorstrup, P., & Bazan, N. G. (2011) · Epilepsia · doi:10.1111/j.1528-1167.2011.03081.x · Cited by 71 · see citing works
Alzheimer's disease--a dysfunction in cholesterol and lipid metabolism
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Self-citationBhattacharjee, S., Jun, B., Belayev, L., Heap, J., Kautzmann, M.-A., Obenaus, A., Menghani, H., Marcell, S. J., Khoutorova, L., Yang, R., et al. (2017) · Science Advances · doi:10.1126/sciadv.1700735 · Cited by 57 · see citing works
Self-citationBasselin, M., Kim, H.-W., Chen, M., Ma, K., Rapoport, S. I., Murphy, R. C., & Farias, S. E. (2010) · Journal of Lipid Research · doi:10.1194/jlr.m002469 · Cited by 52 · see citing works
RetractedCalandria, J. M., Asatryan, A., Balaszczuk, V, Knott, E. J., Jun, B. K., Mukherjee, P. K., Belayev, L., & Bazan, N. G. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.233 · Cited by 47 · see citing works
Petasis, N. A., Yang, R., Winkler, J. W., Zhu, M., Uddin, J., Bazan, N. G., & Serhan, C. N. (2012) · Tetrahedron Letters · doi:10.1016/j.tetlet.2012.01.032 · Cited by 45 · see citing works
Self-citationMusto, A. E., Walker, C. P., Petasis, N. A., & Bazan, N. G. (2015) · PLOS ONE · doi:10.1371/journal.pone.0116543 · Cited by 39 · see citing works
Self-citationChiang, N., & Serhan, C. N. (2006) · Comprehensive Therapy · doi:10.1007/s12019-006-0005-6 · Cited by 17 · see citing works
Self-citation
- Authors
- Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., & Bazan, N. G.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Bazan, Nicolas G.
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2003-10
- Volume
- 278
- Issue
- 44
- Pages
- 43807-43817
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W2100726346
- Cited by
- 802
- References
- 37
- Citations by year
- 2026: 8 · 2025: 12 · 2024: 10 · 2023: 25 · 2022: 23 · 2021: 22 · 2020: 26 · 2019: 29 · 2018: 35 · 2017: 20 · 2016: 28 · 2015: 39 · 2014: 39 · 2013: 50 · 2012: 50
- FWCI
- 35.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Science Foundation
- National Institutes of Health (GM 38765, AG18031)
- National Institute on Aging (AG18031, R01AG018031)
- National Institute of General Medical Sciences (GM 38765)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK060583)
- National Institute of Neurological Disorders and Stroke (R01NS023002, NS23002)
- National Institute of Dental and Craniofacial Research (P01 DE 13499, P01DE013499)
- National Center for Research Resources (P20RR016816)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- docosanoids, docosahexaenoic acid, ischemic stroke, cerebral ischemia-reperfusion injury, leukocyte infiltration, neuroinflammation, resolvins, aspirin, NF-κB, cyclooxygenase-2, IL-1β, lipid peroxidation, neuroprotection, lipidomics, endogenous lipid mediators
- MeSH terms
- Animals, Anti-Inflammatory Agents, Non-Steroidal, Aspirin, Brain, Cells, Cultured, Cerebral Arteries, Docosahexaenoic Acids, Hippocampus, Humans, Immunohistochemistry, Interleukin-1, Isoenzymes, Leukocytes, Membrane Proteins, Microscopy, Fluorescence, Models, Chemical, Neurons, Prostaglandin-Endoperoxide Synthases, Stem Cells, Time Factors, Lipid Peroxidation, Signal Transduction, Reperfusion Injury, NF-kappa B, Mice, Cyclooxygenase 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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