The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
TRIM5α mediates the postentry block to N-tropic murine leukemia viruses in human cells
Open accessAbstract
Murine leukemia viruses (MLVs) have been classified as N-tropic (N-MLV) or B-tropic (B-MLV), depending on their ability to infect particular mouse strains. The early phase of N-MLV infection is blocked in the cells of several mammalian species, including humans. This block is mediated by a dominant host factor that targets the viral capsid soon after virus entry into the cell has been achieved. A similar block to HIV-1 in rhesus monkey cells is mediated by TRIM5α. Here we show that human TRIM5α is both necessary and sufficient for the restriction of N-MLV in human cells. Rhesus monkey TRIM5α, which potently blocks HIV-1 infection, exhibited only modest inhibition of N-MLV infection. B-MLV was resistant to the antiviral effects of both human and rhesus monkey TRIM5α; susceptibility to TRIM5α-mediated restriction was conferred by alteration of residue 110 of the B-MLV capsid protein to the amino acid found in the N-MLV capsid. Our results demonstrate that species-specific variation in TRIM5α governs its ability to block infection by diverse retroviruses.
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Cites
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Cited by
TRIM family proteins: retroviral restriction and antiviral defence
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TRIM5 is an innate immune sensor for the retrovirus capsid lattice
Pertel, T., Hausmann, S., Morger, D., Züger, S., Guerra, J., Lascano, J., Reinhard, C., Santoni, F. A., Uchil, P. D., Chatel, L., et al. (2011) · Nature · doi:10.1038/nature09976 · Cited by 645
Intrinsic immunity: a front-line defense against viral attack
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A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction
Yap, M. W., Nisole, S., & Stoye, J. P. (2005) · Current Biology · doi:10.1016/j.cub.2004.12.042 · Cited by 408
Metadata
- Authors
- Perron, M. J., Stremlau, M., Song, B., Ulm, W., Mulligan, R. C., & Sodroski, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-07-27
- Volume
- 101
- Issue
- 32
- Pages
- 11827-11832
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012780464
- Cited by
- 290
- References
- 37
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- green
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