The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Molecular Characterization and Placental Expression of HERV-W, a New Human Endogenous Retrovirus Family
Open accessAbstract
The multiple sclerosis-associated retrovirus (MSRV) isolated from plasma of MS patients was found to be phylogenetically and experimentally related to human endogenous retroviruses (HERVs). To characterize the MSRV-related HERV family and to test the hypothesis of a replication-competent HERV, we have investigated the expression of MSRV-related sequences in healthy tissues. The expression of MSRV-related transcripts restricted to the placenta led to the isolation of overlapping cDNA clones from a cDNA library. These cDNAs spanned a 7.6-kb region containing gag , pol , and env genes; RU5 and U3R flanking sequences; a polypurine tract; and a primer binding site (PBS). As this PBS showed similarity to avian retrovirus PBSs used by tRNA Trp , this new HERV family was named HERV-W. Several genomic elements were identified, one of them containing a complete HERV-W unit, spanning all cDNA clones. Elements of this multicopy family were not replication competent, as gag and pol open reading frames (ORFs) were interrupted by frameshifts and stop codons. A complete ORF putatively coding for an envelope protein was found both on the HERV-W DNA prototype and within an RU5- env -U3R polyadenylated cDNA clone. Placental expression of 8-, 3.1-, and 1.3-kb transcripts was observed, and a putative splicing strategy was described. The apparently tissue-restricted HERV-W long terminal repeat expression is discussed with respect to physiological and pathological contexts.
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Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022
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Blond, J.-L., Lavillette, D., Cheynet, V., Bouton, O., Oriol, G., Chapel-Fernandes, S., Mandrand, B., Mallet, F., & Cosset, F.-L. (2000) · Journal of Virology · doi:10.1128/jvi.74.7.3321-3329.2000 · Cited by 716
Self-citationBlaise, S., de Parseval, N., Bénit, L., & Heidmann, T. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2132646100 · Cited by 566
Antony, J. M., van Marle, G., Opii, W., Butterfield, D. A., Mallet, F., Yong, V. W., Wallace, J. L., Deacon, R. M., Warren, K., & Power, C. (2004) · Nature Neuroscience · doi:10.1038/nn1319 · Cited by 388
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Metadata
- Authors
- Blond, J.-L., Besème, F., Duret, L., Bouton, O., Bedin, F., Perron, H., Mandrand, B., & Mallet, F.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1999-02
- Volume
- 73
- Issue
- 2
- Pages
- 1175-1185
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2126701599
- Cited by
- 377
- References
- 54
- FWCI
- 26.24
- Type
- journal article
- Language
- en
- Open access
- green
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- Blond, J.-L., Besème, F., Duret, L., Bouton, O., Bedin, F., Perron, H., Mandrand, B., & Mallet, F. (1999). Molecular Characterization and Placental Expression of HERV-W, a New Human Endogenous Retrovirus Family. Journal of Virology. https://doi.org/10.1128/jvi.73.2.1175-1185.1999
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