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A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES
Open accessAbstract
Previous studies have indicated that all naturally occurring murine leukemia viruses propagate significantly more efficiently on embryo cells of either NIH Swiss or BALB/c mice. Studies of the plaquing efficiency of representative viruses on embryo cells of various inbred and hybrid mice indicate that the pattern of sensitivity of the cells is genetically determined. All of 23 strains tested were found to resemble either NIH Swiss (N-type) or BALB/c (B-type) with respect to plaquing efficiency of these viruses. Virus growth on embryo cells derived from (N-type x B-type)F1 hybrids indicated dominance of resistance to both types of viruses. Backcross hybrid studies indicated that a single locus is the primary determinant of the host-range patterns observed. This locus has no effect on growth of certain laboratory-passaged leukemia viruses which propagate equally well on embryo cells of all mouse strains, F1, and backcross hybrids. Though other genetic and nongenetic factors influence viral growth or expression in vitro and in vivo, the genetic locus described appears of major significance in the biology of murine leukemia.
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Citations
Cited by
Intrinsic immunity: a front-line defense against viral attack
Bieniasz, P. D. (2004) · Nature Immunology · doi:10.1038/ni1125 · Cited by 454
Genetic Control Of Murine Viral Leukemogenesis
(1973) · Advances in Cancer Research · doi:10.1016/s0065-230x(08)60532-1 · Cited by 446
Origins and evolutionary consequences of ancient endogenous retroviruses
Johnson, W. E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0189-2 · Cited by 404
Evolutionary conflicts between viruses and restriction factors shape immunity
Duggal, N. K., & Emerman, M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3295 · Cited by 366
TRIM5α mediates the postentry block to N-tropic murine leukemia viruses in human cells
Perron, M. J., Stremlau, M., Song, B., Ulm, W., Mulligan, R. C., & Sodroski, J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403364101 · Cited by 290
Metadata
- Authors
- Pincus, T., Hartley, J. W., & Rowe, W. P.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 1971-06-01
- Volume
- 133
- Issue
- 6
- Pages
- 1219-1233
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2116489938
- Cited by
- 394
- References
- 0
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES. https://app.cochat.ai/papers/10.1084/jem.133.6.1219
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- Pincus, T., Hartley, J. W., & Rowe, W. P. (1971). A MAJOR GENETIC LOCUS AFFECTING RESISTANCE TO INFECTION WITH MURINE LEUKEMIA VIRUSES. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.133.6.1219
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
