The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A rare-cell detector for cancer
Open accessAbstract
Although a reliable method for detection of cancer cells in blood would be an important tool for diagnosis and monitoring of solid tumors in early stages, current technologies cannot reliably detect the extremely low concentrations of these rare cells. The preferred method of detection, automated digital microscopy (ADM), is too slow to scan the large substrate areas. Here we report an approach that uses fiber-optic array scanning technology (FAST), which applies laser-printing techniques to the rare-cell detection problem. With FAST cytometry, laser-printing optics are used to excite 300,000 cells per sec, and emission is collected in an extremely wide field of view, enabling a 500-fold speed-up over ADM with comparable sensitivity and superior specificity. The combination of FAST enrichment and ADM imaging has the performance required for reliable detection of early-stage cancer in blood.
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Cites
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Combined transcriptome and genome analysis of single micrometastatic cells
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Cited by
Isolation of circulating tumor cells using a microvortex-generating herringbone-chip
Stott, S. L., Hsu, C.-H., Tsukrov, D. I., Yu, M., Miyamoto, D. T., Waltman, B. A., Rothenberg, S. M., Shah, A. M., Smas, M. E., Korir, G. K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012539107 · Cited by 1,634
Detection, clinical relevance and specific biological properties of disseminating tumour cells
Pantel, K., Brakenhoff, R. H., & Brandt, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2375 · Cited by 1,118
Microfluidics for cell separation
Bhagat, A. A. S., Bow, H., Hou, H. W., Tan, S. J., Han, J., & Lim, C. T. (2010) · Medical & Biological Engineering & Computing · doi:10.1007/s11517-010-0611-4 · Cited by 632
Toner, M., & Irimia, D. (2005) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.7.011205.135108 · Cited by 623
Circulating Tumor Cells and Circulating Tumor DNA
Alix-Panabières, C., Schwarzenbach, H., & Pantel, K. (2012) · Annual Review of Medicine · doi:10.1146/annurev-med-062310-094219 · Cited by 485
Metadata
- Authors
- Krivacic, R. T., Ladanyi, A., Curry, D. N., Hsieh, H. B., Kuhn, P., Bergsrud, D. E., Kepros, J. F., Barbera, T., Ho, M. Y., Chen, L. B., Lerner, R. A., & Bruce, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-07-12
- Volume
- 101
- Issue
- 29
- Pages
- 10501-10504
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2057306577
- Cited by
- 340
- References
- 8
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- green
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- Krivacic, R. T., Ladanyi, A., Curry, D. N., Hsieh, H. B., Kuhn, P., Bergsrud, D. E., Kepros, J. F., Barbera, T., Ho, M. Y., Chen, L. B., Lerner, R. A., & Bruce, R. H. (2004). A rare-cell detector for cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404036101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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