The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1
Open accessAbstract
Lv1 restriction of HIV-1 in the cells of Old World monkeys is associated with the expression of the Trim5 gene. Uniquely, in owl monkey kidney cells, HIV-1 restriction is dependent on the ability of incoming viral capsid protein to bind cyclophilin A (CypA). Cloning of the owl monkey Trim5 gene now reveals the presence of an inserted CypA pseudogene within intron 7 of the Trim5 gene. This insertion results in the formation of a chimeric Trim5-CypA transcript. Transfer of a cDNA corresponding to this transcript into human cells confers cyclosporin A-sensitive resistance to HIV-1 infection. The restriction factor appears to be a chimeric protein created by retrotransposon-mediated exon shuffling.
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Frohman, M. A., Dush, M. K., & Martin, G. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.23.8998 · Cited by 4,577
Mobile Elements: Drivers of Genome Evolution
Kazazian, H. H. (2004) · Science · doi:10.1126/science.1089670 · Cited by 1,922
The cytoplasmic body component TRIM5α restricts HIV-1 infection in Old World monkeys
Stremlau, M., Owens, C. M., Perron, M. J., Kiessling, M., Autissier, P., & Sodroski, J. (2004) · Nature · doi:10.1038/nature02343 · Cited by 1,816
The tripartite motif family identifies cell compartments
Reymond, A., Meroni, G., Fantozzi, A., Merla, G., Cairo, S., Luzi, L., Riganelli, D., Zanaria, E., Messali, S., Cainarca, S., et al. (2001) · The EMBO Journal · doi:10.1093/emboj/20.9.2140 · Cited by 1,366
DNA Deamination Mediates Innate Immunity to Retroviral Infection
Harris, R. S., Bishop, K. N., Sheehy, A. M., Craig, H. M., Petersen-Mahrt, S. K., Watt, I. N., Neuberger, M. S., & Malim, M. H. (2003) · Cell · doi:10.1016/s0092-8674(03)00423-9 · Cited by 1,266
Weiner, A. M., Deininger, P. L., & Efstratiadis, A. (1986) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.55.070186.003215 · Cited by 1,030
Human LINE retrotransposons generate processed pseudogenes
Esnault, C., Maestre, J., & Heidmann, T. (2000) · Nature Genetics · doi:10.1038/74184 · Cited by 830
Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B
Luban, J., Bossolt, K. L., Franke, E. K., Kalpana, G. V., & Goff, S. P. (1993) · Cell · doi:10.1016/0092-8674(93)90637-6 · Cited by 802
Specific incorporation of cyclophilin A into HIV-1 virions
Franke, E. K., Yuan, H. E. H., & Luban, J. (1994) · Nature · doi:10.1038/372359a0 · Cited by 745
Cyclophilin A retrotransposition into TRIM5 explains owl monkey resistance to HIV-1
Sayah, D. M., Sokolskaja, E., Berthoux, L., & Luban, J. (2004) · Nature · doi:10.1038/nature02777 · Cited by 662
Cited by
TRIM family proteins: retroviral restriction and antiviral defence
Nisole, S., Stoye, J. P., & Saïb, A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1248 · Cited by 761
Self-citationStremlau, M., Perron, M., Welikala, S., & Sodroski, J. (2005) · Journal of Virology · doi:10.1128/jvi.79.5.3139-3145.2005 · Cited by 373
Reconstitution of an Infectious Human Endogenous Retrovirus
Lee, Y. N., & Bieniasz, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030010 · Cited by 311
Complementary assays reveal a relationship between HIV-1 uncoating and reverse transcription
Hulme, A. E., Perez, O., & Hope, T. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014522108 · Cited by 276
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Metadata
- Authors
- Nisole, S., Lynch, C., Stoye, J. P., & Yap, M. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-08-23
- Volume
- 101
- Issue
- 36
- Pages
- 13324-13328
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2144904664
- Cited by
- 304
- References
- 42
- FWCI
- 8.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Nisole, S., Lynch, C., Stoye, J. P., & Yap, M. W. (2004). A Trim5-cyclophilin A fusion protein found in owl monkey kidney cells can restrict HIV-1. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0404640101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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