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Cited by 309

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis

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Dalton, Timothy P., He, Lei, Wang, Bin, Miller, Marian L., Jin, Li, Stringer, Keith F., Chang, Xiaoqing, Baxter, C. Stuart, Nebert, Daniel W.·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0406085102
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Abstract

Testicular necrosis is a sensitive endpoint for cadmium (Cd 2+ , Cd) toxicity across all species tested. Resistance to Cd-induced testicular damage is a recessive trait assigned to the Cdm locus on mouse chromosome 3. We first narrowed the Cdm -gene-containing region to 880 kb. SNP analysis of this region from two sensitive and two resistant inbred strains demonstrated a 400-kb haplotype block consistent with the Cd-induced toxicity phenotype; in this region is the Slc39a8 gene encoding a member of the solute-carrier superfamily. Slc39a8 encodes SLC39A8 (ZIP8), whose homologs in plant and yeast are putative zinc transporters. We show here that ZRT-, IRT-like protein (ZIP)8 expression in cultured mouse fetal fibroblasts leads to a >10-fold increase in the rate of intracellular Cd influx and accumulation and 30-fold increase in sensitivity to Cd-induced cell death. The complete ZIP8 mRNA and intron-exon splice junctions have no nucleotide differences between two sensitive and two resistant strains of mice; by using situ hybridization, we found that ZIP8 mRNA is prominent in the vascular endothelial cells of the testis of the sensitive strains of mice but absent in these cells of resistant strains. Slc39a8 is therefore the Cdm gene, defining sensitivity to Cd toxicity specifically in vascular endothelial cells of the testis.

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Metadata

Authors
Dalton, T. P., He, L., Wang, B., Miller, M. L., Jin, L., Stringer, K. F., Chang, X., Baxter, C. S., & Nebert, D. W.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2005-02-18
Volume
102
Issue
9
Pages
3401-3406
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0406085102
OpenAlex
W2100913647
Cited by
309
References
42
FWCI
9.89
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. https://app.cochat.ai/papers/10.1073/pnas.0406085102
The paper
Dalton, T. P., He, L., Wang, B., Miller, M. L., Jin, L., Stringer, K. F., Chang, X., Baxter, C. S., & Nebert, D. W. (2005). Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0406085102

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