The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Self-generated diversity produces “insurance effects” in biofilm communities
Open accessAbstract
Diversity generally protects communities from unstable environmental conditions. This principle, known as the “insurance hypothesis,” has been tested in many different ecosystems. Here we show that the opportunistic pathogen Pseudomonas aeruginosa undergoes extensive genetic diversification during short-term growth in biofilm communities. The induced genetic changes are produced by a recA -dependent mechanism and affect multiple traits, including the behavior of the bacteria in biofilms. Some biofilm-derived variants exhibit an increased ability to disseminate, whereas others manifest accelerated biofilm formation. Furthermore, the presence of these functionally diverse bacteria increases the ability of biofilms to resist an environmental stress. These findings suggest that self-generated diversity in biofilms provides a form of biological insurance that can safeguard the community in the face of adverse conditions.
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Cites
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The Involvement of Cell-to-Cell Signals in the Development of a Bacterial Biofilm
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Biodiversity and ecosystem productivity in a fluctuating environment: The insurance hypothesis
Yachi, S., & Loreau, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1463 · Cited by 3,211
Productivity and sustainability influenced by biodiversity in grassland ecosystems.
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Diversity and Productivity in a Long-Term Grassland Experiment
Tilman, D., Reich, P. B., Knops, J., Wedin, D., Mielke, T., & Lehman, C. (2001) · Science · doi:10.1126/science.1060391 · Cited by 2,373
A component of innate immunity prevents bacterial biofilm development
Singh, P. K., Parsek, M. R., Greenberg, E. P., & Welsh, M. J. (2002) · Nature · doi:10.1038/417552a · Cited by 1,026
Self-citationHighly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection
Häußler, S., Ziegler, I., Löttel, A., Götz, F. V., Rohde, M., Wehmhöhner, D., Saravanamuthu, S., Tümmler, B., & Steinmetz, I. (2003) · Journal of Medical Microbiology · doi:10.1099/jmm.0.05069-0 · Cited by 228
Cited by
Flemming, H.-C., & Wingender, J. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2415 · Cited by 10,137
Biofilms: an emergent form of bacterial life
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S. A., & Kjelleberg, S. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.94 · Cited by 5,979
Physiological heterogeneity in biofilms
Stewart, P. S., & Franklin, M. J. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1838 · Cited by 2,327
Ecological consequences of genetic diversity
Hughes, A. R., Inouye, B. D., Johnson, M. T. J., Underwood, N., & Vellend, M. (2008) · Ecology Letters · doi:10.1111/j.1461-0248.2008.01179.x · Cited by 1,834
Ecology of Cyanobacteria II: Their Diversity in Space and Time
(2012) · doi:10.1007/978-94-007-3855-3 · Cited by 1,078
Metadata
- Authors
- Boles, B. R., Thoendel, M., & Singh, P. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-11-16
- Volume
- 101
- Issue
- 47
- Pages
- 16630-16635
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2165400633
- Cited by
- 670
- References
- 7
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- green
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- Boles, B. R., Thoendel, M., & Singh, P. K. (2004). Self-generated diversity produces “insurance effects” in biofilm communities. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0407460101
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
