The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification
Open accessAbstract
Collagenase-3 (MMP13), a member of the matrix metalloproteinase (MMP) family of neutral endopeptidases, is expressed in the skeleton during embryonic development and is highly overexpressed in human carcinomas and in chondrocytes and synovial cells in rheumatoid arthritis and osteoarthritis. To determine the functional roles of Mmp13, we generated Mmp13 -null mice that showed profound defects in growth plate cartilage with markedly increased hypertrophic domains as well as delay in endochondral ossification and formation and vascularization of primary ossification centers. Absence of Mmp13 resulted in significant interstitial collagen accumulation due, in part, to the lack of appropriate collagenase-mediated cleavage that normally occurs in growth plates and primary ossification centers. Cartilaginous growth plate abnormalities persisted in adult mice and phenocopied defects observed in human hereditary chondrodysplasias. Our findings demonstrate a unique role of Mmp13 in skeletal development.
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How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Ohuchi, E., Imai, K., Fujii, Y., Sato, H., Seiki, M., & Okada, Y. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.4.2446 · Cited by 938
Engsig, M. T., Chen, Q.-J., Vu, T. H., Pedersen, A.-C., Therkidsen, B., Lund, L. R., Henriksen, K., Lenhard, T., Foged, N. T., Werb, Z., et al. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.4.879 · Cited by 596
Cited by
Matrix metalloproteinases and the regulation of tissue remodelling
Page-McCaw, A., Ewald, A. J., & Werb, Z. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2125 · Cited by 2,630
Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation
Yang, L., Tsang, K. Y., Tang, H. C., Chan, D., & Cheah, K. S. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1302703111 · Cited by 760
Progress in matrix metalloproteinase research
MURPHY, G., & NAGASE, H. (2008) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2008.05.002 · Cited by 759
Matrix metalloproteinases (MMPs) in health and disease: an overview
Malemud, C. (2006) · Frontiers in Bioscience · doi:10.2741/1915 · Cited by 705
Little, C. B., Barai, A., Burkhardt, D., Smith, S. M., Fosang, A. J., Werb, Z., Shah, M., & Thompson, E. W. (2009) · Arthritis & Rheumatism · doi:10.1002/art.25002 · Cited by 642
Metadata
- Authors
- Inada, M., Wang, Y., Byrne, M. H., Rahman, M. U., Miyaura, C., López-Otín, C., & Krane, S. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-11-24
- Volume
- 101
- Issue
- 49
- Pages
- 17192-17197
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2093353711
- Cited by
- 575
- References
- 3
- FWCI
- 14.90
- Type
- journal article
- Language
- en
- Open access
- green
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- Inada, M., Wang, Y., Byrne, M. H., Rahman, M. U., Miyaura, C., López-Otín, C., & Krane, S. M. (2004). Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0407788101
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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