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Colonic tumorigenesis in BubR1 +/– Apc Min /+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability
Open accessAbstract
Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle checkpoint, a surveillance mechanism preventing the cell from prematurely entering anaphase. The adenomatous polyposis coli ( Apc ) gene also plays an important role in regulating genomic stability, as mutations of Apc cause aneuploidy. Here we show that whereas Apc Min /+ mice developed many adenomatous polyps, mostly in the small intestine, by 3 mo of age; BubR1 +/– Apc Min /+ compound mutant mice developed 10 times more colonic tumors than Apc Min /+ mice. The colonic tumors in BubR1 +/– Apc Min /+ mice were in higher grades than those observed in Apc Min /+ mice. Consistently, BubR1 +/– Apc Min /+ murine embryonic fibroblasts (MEFs) contained more β-catenin and proliferated at a faster rate than WT or BubR1 +/– MEFs. Moreover, BubR1 +/– Apc Min /+ MEFs slipped through mitosis in the presence of nocodazole and exhibited a higher rate of genomic instability than that of WT or BubR1 +/– or Apc Min /+ MEFs, accompanied by premature separation of sister chromatids. Together, our studies suggest that BubR1 and Apc functionally interact in regulating metaphase–anaphase transition, deregulation of which may play a key role in genomic instability and development and progression of colorectal cancer.
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Genetic instabilities in human cancers
Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/25292 · Cited by 4,168
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731
Cited by
The Chromosomal Instability Pathway in Colon Cancer
Pino, M. S., & Chung, D. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.065 · Cited by 932
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis
Holland, A. J., & Cleveland, D. W. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2718 · Cited by 859
Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor
Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612
Fenech, M. (2006) · Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis · doi:10.1016/j.mrfmmm.2006.05.028 · Cited by 466
Metadata
- Authors
- Rao, C. V., Yang, Y.-M., Swamy, M. V., Liu, T., Fang, Y., Mahmood, R., Jhanwar-Uniyal, M., & Dai, W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-03-14
- Volume
- 102
- Issue
- 12
- Pages
- 4365-4370
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1997937385
- Cited by
- 160
- References
- 2
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Colonic tumorigenesis in BubR1 +/– Apc Min /+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. https://app.cochat.ai/papers/10.1073/pnas.0407822102
- The paper
- Rao, C. V., Yang, Y.-M., Swamy, M. V., Liu, T., Fang, Y., Mahmood, R., Jhanwar-Uniyal, M., & Dai, W. (2005). Colonic tumorigenesis in BubR1 +/– Apc Min /+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0407822102
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