The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The cAMP binding domain: An ancient signaling module
Open accessAbstract
cAMP-binding domains from several different proteins were analyzed to determine the properties and interactions of this recognition motif. Systematic computational analyses, including structure-based sequence comparison, surface matching, affinity grid analysis, and analyses of the ligand protein interactions were carried out. These analyses show distinctive roles of the sugar phosphate and the adenine in the cAMP-binding module. We propose that the cAMP-binding regulatory proteins function by providing an allosteric system in which the presence or absence of cAMP produces a substantial structural change through the loss of hydrophobic interactions with the adenine ring and consequent repositioning of the C helix. The modified positioning of the helix in turn is recognized by a protein-binding event, completing the allostery.
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Cites
Kabsch, W., & Sander, C. (1983) · Biopolymers · doi:10.1002/bip.360221211 · Cited by 15,320
Cited by
Epac and PKA: a tale of two intracellular cAMP receptors
Cheng, X., Ji, Z., Tsalkova, T., & Mei, F. (2008) · Acta Biochimica et Biophysica Sinica · doi:10.1111/j.1745-7270.2008.00438.x · Cited by 340
cAMP activation of PKA defines an ancient signaling mechanism
Das, R., Esposito, V., Abu-Abed, M., Anand, G. S., Taylor, S. S., & Melacini, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609033103 · Cited by 130
Self-citationAmplification of signaling via cellular allosteric relay and protein disorder
Ma, B., & Nussinov, R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903024106 · Cited by 36
The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell
Andreas, M. P., & Giessen, T. W. (2024) · Nature Communications · doi:10.1038/s41467-024-54175-4 · Cited by 14
The Evolution of Function in the DNA-Binding Domain of the CRP/FNR Family
Krishnaswamy, M., & Seshasayee, A. S. N. (2025) · Genome Biology and Evolution · doi:10.1093/gbe/evaf182 · Cited by 3
Metadata
- Authors
- Berman, H. M., Ten Eyck, L. F., Goodsell, D. S., Haste, N. M., Kornev, A., & Taylor, S. S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-12-23
- Volume
- 102
- Issue
- 1
- Pages
- 45-50
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2167344126
- Cited by
- 212
- References
- 1
- FWCI
- 3.72
- Type
- journal article
- Language
- en
- Open access
- green
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- Berman, H. M., Ten Eyck, L. F., Goodsell, D. S., Haste, N. M., Kornev, A., & Taylor, S. S. (2005). The cAMP binding domain: An ancient signaling module. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0408579102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
