The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis
Open accessAbstract
Sister chromatids in mammalian cells remain attached mostly at their centromeres at metaphase because of the loss of cohesion along chromosome arms in prophase. Here, we report that Bub1 retains centromeric cohesion in mitosis of human cells. Depletion of Bub1 or Shugoshin (Sgo1) in HeLa cells by RNA interference causes massive missegregation of sister chromatids that originates at centromeres. Surprisingly, loss of chromatid cohesion in Bub1 and Sgo1 RNA-interference cells does not appear to require the full activation of separase but, instead, triggers a mitotic arrest that depends on Mad2 and Aurora B. Bub1 maintains the steady-state levels and centromeric localization of Sgo1. Therefore, Bub1 protects centromeric cohesion through Shugoshin in mitosis.
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Cites
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Self-citationCleavage of Cohesin by the CD Clan Protease Separin Triggers Anaphase in Yeast
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Wapl controls the dynamic association of cohesin with chromatin
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Mps1 phosphorylates Borealin to control Aurora B activity and chromosome alignment
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Metadata
- Authors
- Tang, Z., Sun, Y., Harley, S. E., Zou, H., & Yu, H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2004-12-16
- Volume
- 101
- Issue
- 52
- Pages
- 18012-18017
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2141848891
- Cited by
- 257
- References
- 37
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Tang, Z., Sun, Y., Harley, S. E., Zou, H., & Yu, H. (2004). Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0408600102
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
