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Cited by 56Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

DARPP-32: A molecular switch at the nexus of reward pathway plasticity

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Gould, Todd D., Manji, Husseini K.·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0408700102PMC PMC544318
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Abstract

Substance-related disorders represent a major burden to afflicted individuals, their families, and society. Repeated drug use can result in addiction, manifested as an intense desire for the drug, along with an impaired ability to temper its use, even in the face of serious consequences. Many tens of millions of people are addicted to drugs of abuse, and with costs to society in the many hundreds of billions of dollars per annum, there is little doubt that understanding the consummate processes (followed by advances in treatments) represents a major goal for medicine (1, 2). Although many transmitters have been implicated in the effects of the various types of drugs of abuse, dopamine and, more recently, glutamate have been most consistently associated with the reinforcing effects. Indeed, there is considerable evidence that the mesolimbic dopaminergic pathway plays a crucial role in the selection and orchestration of goal-directed behaviors, particularly those elicited by incentive stimuli. Drugs of abuse increase extracellular dopamine concentrations in limbic regions, including the nucleus accumbens (1, 2). However, a growing body of data suggests that increases in dopamine are not directly related to reward per se , but, rather, to the learned anticipation of reward and incentive salience (3). Notably, salience affects the motivation to seek the anticipated reward and facilitates conditioned learning (3). The key role of conditioned learning has focused attention on neural systems that attribute incentive salience, most notably a circuit that includes glutamate projections from the prefrontal cortex to the nucleus accumbens and dorsal striatum. This finding has led to the hypothesis that key biochemical events underlying drug-induced changes in neural plasticity should occur specifically in neurons inervated by both dopamine and glutamate inputs. In this issue of PNAS, Valjent et al. (4) provide an important link, implicating dopamine, cAMP-regulated phosphoprotein …

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  1. [1]Hyman, S. E. & Malenka, R. C. (2001) Nat. Rev. Neurosci. 2, 695-703. [DOI] [PubMed] [Google Scholar]
  2. [2]Chao, J. & Nestler, E. J. (2004) Annu. Rev. Med. 55, 113-132. [DOI] [PubMed] [Google Scholar]
  3. [3]Volkow, N. D., Fowler, J. S., Wang, G. J. & Swanson, J. M. (2004) Mol. Psychiatry 9, 557-569. [DOI] [PubMed] [Google Scholar]
  4. [4]Valjent, E., Pascoli, V., Svenningsson, P., Paul, S., Enslen, H., Corvol, J.-C., Stipanovich, A., Caboche, J., Lombroso, P. J., Nairn, A. C., et al. (2005) Proc. Natl. Acad. Sci. USA 102, 491-496. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. [5]Greengard, P., Allen, P. B. & Nairn, A. C. (1999) Neuron 23, 435-447. [DOI] [PubMed] [Google Scholar]
  6. [6]Fienberg, A. A., Hiroi, N., Mermelstein, P. G., Song, W., Snyder, G. L., Nishi, A., Cheramy, A., O'Callaghan, J. P., Miller, D. B., Cole, D. G., et al. (1998) Science 281, 838-842. [DOI] [PubMed] [Google Scholar]
  7. [7]Calabresi, P., Gubellini, P., Centonze, D., Picconi, B., Bernardi, G., Chergui, K., Svenningsson, P., Fienberg, A. A. & Greengard, P. (2000) J. Neurosci. 20, 8443-8451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. [8]Snyder, G. L., Allen, P. B., Fienberg, A. A., Valle, C. G., Huganir, R. L., Nairn, A. C. & Greengard, P. (2000) J. Neurosci. 20, 4480-4488. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. [9]Tsukamoto, T., Iyo, M., Tani, K., Sekine, Y., Hashimoto, K., Ohashi, Y., Suzuki, K., Iwata, Y. & Mori, N. (2001) Psychopharmacology 158, 107-113. [DOI] [PubMed] [Google Scholar]
  10. [10]Halpain, S., Girault, J. A. & Greengard, P. (1990) Nature 343, 369-372. [DOI] [PubMed] [Google Scholar]
  11. [11]Manji, H. K., Gottesman, I. I. & Gould, T. D. (2003) Sci. STKE 207, pe49. [DOI] [PubMed] [Google Scholar]
  12. [12]Kandel, E. R. (2001) Science 294, 1030-1038. [DOI] [PubMed] [Google Scholar]
  13. [13]Mazzucchelli, C., Vantaggiato, C., Ciamei, A., Fasano, S., Pakhotin, P., Krezel, W., Welzl, H., Wolfer, D. P., Pages, G., Valverde, O., et al. (2002) Neuron 34, 807-820. [DOI] [PubMed] [Google Scholar]
  14. [14]Einat, H., Yuan, P., Gould, T. D., Li, J., Du, J., Zhang, L., Manji, H. K. & Chen, G. (2003) J. Neurosci. 23, 7311-7316. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. [15]Bhalla, U. S., Ram, P. T. & Iyengar, R. (2002) Science 297, 1018-1023. [DOI] [PubMed] [Google Scholar]
  16. [16]Pozzi, L., Hakansson, K., Usiello, A., Borgkvist, A., Lindskog, M., Greengard, P. & Fisone, G. (2003) J. Neurochem. 86, 451-459. [DOI] [PubMed] [Google Scholar]
  17. [17]Valjent, E., Pages, C., Herve, D., Girault, J. A. & Caboche, J. (2004) Eur. J. Neurosci. 19, 1826-1836. [DOI] [PubMed] [Google Scholar]

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Authors
Gould, T. D., & Manji, H. K.
Affiliations
National Institutes of Health (US)
ORCID
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2005-01-04
Volume
102
Issue
2
Pages
253-254
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0408700102
PMC
PMC544318
OpenAlex
W2050088352
Cited by
56
References
18
Citations by year
2026: 1 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 3
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
DARPP-32, drug addiction, mesolimbic dopamine system, nucleus accumbens, glutamate, incentive salience, conditioned learning, substance-related disorders, neuroplasticity, prefrontal cortex
MeSH terms
Animals, Corpus Striatum, Dopamine, Nerve Tissue Proteins, Neuronal Plasticity, Phosphoproteins, Glutamic Acid, MAP Kinase Signaling System, Mice, Dopamine and cAMP-Regulated Phosphoprotein 32

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