The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Open accessAbstract
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.
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“Although the CAR-driven c-Myc–Foxm1 axis has been implicated in promoting hepatocyte proliferation and regeneration in rodents,43,44”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [44]
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Induction of apoptosis in fibroblasts by c-myc protein
Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M. W., Waters, C. M., Penn, L. Z., & Hancock, D. C. (1992) · Cell · doi:10.1016/0092-8674(92)90123-t · Cited by 2,941
c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
Dang, C. V. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.1.1 · Cited by 1,722
Inducible Gene Targeting in Mice
Kühn, R., Schwenk, F., Aguet, M., & Rajewsky, K. (1995) · Science · doi:10.1126/science.7660125 · Cited by 1,641
Fausto, N. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80412-2 · Cited by 1,022
del Olmo, J. A., Peña, A., Serra, M. Á., Wassel, A., Benages, A., & Rodrigo, J. M. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(01)68827-5 · Cited by 895
c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function
Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
Shachaf, C. M., Kopelman, A. M., Arvanitis, C., Karlsson, Å., Beer, S., Mandl, S., Bachmann, M. H., Borowsky, A. D., Ruebner, B., Cardiff, R. D., et al. (2004) · Nature · doi:10.1038/nature03043 · Cited by 874
Askew, D. S., Ashmun, R. A., Simmons, B. C., & Cleveland, J. L. (1991) · PubMed · Cited by 867
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation
Wilson, A., Murphy, M. J., Oskarsson, T., Kaloulis, K., Bettess, M. D., Oser, G. M., Pasche, A.-C., Knabenhans, C., MacDonald, H. R., & Trumpp, A. (2004) · Genes & Development · doi:10.1101/gad.313104 · Cited by 823
Drosophila myc Regulates Cellular Growth during Development
Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648
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4 of the 49 references couldn’t be matched to a known paper.
Research works printed but not linked: 12
- Morgenbesser, S. D. & DePinho, R. A. (1994) Semin. Cancer Biol. 5, 21-36.8186385
- Gu, J. R., Hu, L. F., Cheng, Y. C. & Wan, D. F. (1986) J. Cell Physiol. Suppl. 4, 13-20.2427530
- Yaswen, P., Goyette, M., Shank, P. R. & Fausto, N. (1985) Mol. Cell. Biol. 5, 780-786.2581126
- Thompson, N. L., Mead, J. E., Braun, L., Goyette, M., Shank, P. R. & Fausto, N. (1986) Cancer Res. 46, 3111-3117.3516391
- Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L. (1991) Oncogene 6, 1915-1922.1923514
- Sandgren, E. P., Quaife, C. J., Pinkert, C. A., Palmiter, R. D. & Brinster, R. L. (1989) Oncogene 4, 715-724.2543942
- Alboran, I. M., Baena, E. & Martinez, A. C. (2004) Cell Death Differ. 11, 690.
- Maines, J. Z., Stevens, L. M., Tong, X. & Stein, D. (2004) Development (Cambridge, U.K.) 131, 775-786.
- Pierce, S. B., Yost, C., Britton, J. S., Loo, L. W., Flynn, E. M., Edgar, B. A. & Eisenman, R. N. (2004) Development (Cambridge, U.K.) 131, 2317-2327.
- 10.1128/mcb.4.8.1493-1498.1984 · DOI
- Fausto, N., Mead, J. E., Braun, L., Thompson, N. L., Panzica, M., Goyette, M., Bell, G. I. & Shank, P. R. (1986) Symp. Fundam. Cancer Res. 39, 69-86.3321311
- Guo, Q. M., Malek, R. L., Kim, S., Chiao, C., He, M., Ruffy, M., Sanka, K., Lee, N. H., Dang, C. V. & Liu, E. T. (2000) Cancer Res. 60, 5922-5928.11085504
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Items 101–104 of 104
Zhang, K., Li, B., Deng, Z., Dong, Y., Li, Y., Chen, B., Zhao, M., Lu, M., Liu, X., Guo, Z., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.25.595867
The fate of pyruvate dictates cell growth by modulating cellular redox potentialPreprint
Toshniwal, A. G., Lam, G., Bott, A. J., Cluntun, A. A., Skabelund, R. A., Nam, H.-J., Wisidagama, D. R., Thummel, C. S., & Rutter, J. P. (2025) · eLife · doi:10.7554/elife.103705.2
Metadata
- Authors
- Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid, Spain; Institut Universitaire de Recherche Clinique, Laboratoire de Dermatologie Moléculaire Unité Propre de Recherche de l'Enseignement Superieur EA3754, F-34093 Montpellier, France; Departament de Biologia Cellular i Anatomia Patologica, Institut d'Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina,...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-04-27
- Volume
- 102
- Issue
- 20
- Pages
- 7286-7291
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1129100
- OpenAlex
- W2046528425
- Cited by
- 104
- References
- 49
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 6 · 2021: 2 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- c-Myc, hepatocyte proliferation, liver regeneration, hepatocyte size, cell ploidy, liver development, cell growth, transcription factors
- MeSH terms
- Animals, Bromodeoxyuridine, Fluoresceins, Immunohistochemistry, Liver, Ploidies, Poly I-C, Polymerase Chain Reaction, Proto-Oncogene Proteins c-myc, DNA Primers, Mice, Knockout, Hepatocytes, Cell Size, Cell Proliferation, Mice
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