Liver regeneration
Abstract
The liver can precisely regulate its growth and mass. Surgical resection of hepatic lobes or hepatocyte loss caused by viral or chemical injury triggers hepatocyte replication while enlarged liver mass is corrected by apoptosis. Hepatocytes have a great replicative capacity and are capable of repopulating the liver. However, "stem-like" cells proliferate when hepatocyte replication is blocked or delayed. Detailed studies of the mechanisms that regulate liver growth have been done in animals subjected to partial hepatectomy or chemical injury. Substantial progress has been achieved using appropriate transgenic and knockout mouse models for this work. Gene expression in the regenerating liver can be divided into several phases, starting with expression of a large number of immediate early genes. Hepatocytes need to be primed before they can fully respond to the growth factors HGF (Hepatocyte Growth Factor), TGFalpha (Transforming Growth Factor Alpha), and EGF (Epidermal Growth Factor) in vitro. Priming requires the cytokines TNF and IL-6 in addition to other agents that prevent cytotoxicity. Reactive Oxygen Species and glutathione content can determine whether the TNF effect on hepatocytes is proliferative or apoptotic. At least four transcription factors, NFkappaB, STAT3 (which are strongly induced by TNF), AP-1 and C/EBPbeta play major roles in the initiation of liver regeneration. In addition, extensive remodeling of the hepatic extracellular matrix occurs shortly after partial hepatectomy. Progression through the cell cycle beyond the initiation phase requires growth factors. The expression of Cyclin D1 probably establishes the stage at which replication becomes growth factor-independent and autonomous. Knowledge about the mechanisms of liver regeneration can now be applied to correct clinical problems caused by deficient liver growth.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
For regeneration to take place, normally quiescent hepatocytes must gain proliferative capacity and undergo a transition from G0 to G1, a process known as priming.
“For regeneration to take place, normally quiescent hepatocytes must gain proliferative capacity and undergo a transition from G0 to G1, a process known as priming (1,6).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [1]
Priming and progression of hepatocyte proliferation after PH requires the actions of TNF and IL-6 and growth factors such as TGF-alpha and HGF.
“Priming and progression of hepatocyte proliferation after PH requires the actions of TNF and IL-6 and growth factors such as TGF-α and HGF (1,3,5,27).”
From Expression of suppressors of cytokine signaling during liver regeneration (2001) · cites this paper as [1]
Experiments using hepatocyte lineage tracing in mice have shown that in various liver injury models hepatocytes regenerate themselves without any significant contribution from HPCs.
“Experiments utilising hepatocyte lineage tracing in mice have shown in various liver injury models that hepatocytes regenerate themselves without any significant contribution from HPCs18, 19.”
From Hepatic progenitor cells of biliary origin with liver repopulation capacity (2015) · cites this paper as [18]
Cites
NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses
Ghosh, S., May, M. J., & Kopp, E. B. (1998) · Annual Review of Immunology · doi:10.1146/annurev.immunol.16.1.225 · Cited by 5,182 · see citing works
Michalopoulos, G. K., & DeFrances, M. C. (1997) · Science · doi:10.1126/science.276.5309.60 · Cited by 2,828 · see citing works
Higgins, G. (1931) · Cited by 2,444 · see citing works
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
HEINRICH, P. C., BEHRMANN, I., MÜLLER-NEWEN, G., SCHAPER, F., & GRAEVE, L. (1998) · Biochemical Journal · doi:10.1042/bj3340297 · Cited by 2,130 · see citing works
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., & Baltimore, D. (1995) · Nature · doi:10.1038/376167a0 · Cited by 1,828 · see citing works
Liver Failure and Defective Hepatocyte Regeneration in Interleukin-6-Deficient Mice
Cressman, D. E., Greenbaum, L. E., DeAngelis, R. A., Ciliberto, G., Furth, E. E., Poli, V., & Taub, R. (1996) · Science · doi:10.1126/science.274.5291.1379 · Cited by 1,536 · see citing works
Scatter factor/hepatocyte growth factor is essential for liver development
Schmidt, C. S., Bladt, F., Gödecke, S., Brinkmann, V., Zschiesche, W., Sharpe, M. J., Gherardi, E., & Birchmeler, C. (1995) · Nature · doi:10.1038/373699a0 · Cited by 1,395 · see citing works
Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor
Uehara, Y., Minowa, O., Mori, C., Shiota, K., Kuno, J., Noda, T., & Kitamura, N. (1995) · Nature · doi:10.1038/373702a0 · Cited by 1,041 · see citing works
Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor
Miettinen, P. J., Berger, J. E., Meneses, J. J., Phung, Y. T., Pedersen, R. A., Werb, Z., & Derynck, R. (1995) · Nature · doi:10.1038/376337a0 · Cited by 1,038 · see citing works
Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene
Li, Q., Antwerp, D. V., Mercurio, F., Lee, K., & Verma, I. M. (1999) · Science · doi:10.1126/science.284.5412.321 · Cited by 963 · see citing works
Yamada, Y., Kirillova, I., Peschon, J. J., & Fausto, N. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1441 · Cited by 944 · see citing works
Self-citationAbnormal Morphogenesis But Intact IKK Activation in Mice Lacking the IKKα Subunit of IκB Kinase
Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T. J., Ellisman, M. H., Johnson, R. S., & Karin, M. (1999) · Science · doi:10.1126/science.284.5412.316 · Cited by 822 · see citing works
Liver regeneration. 2. Role of growth factors and cytokines in hepatic regeneration.
Fausto, N., Laird, A., & Webber, E. M. (1995) · The FASEB Journal · doi:10.1096/fasebj.9.15.8529831 · Cited by 620 · see citing works
Self-citationLimb and Skin Abnormalities in Mice Lacking IKKα
Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., & Akira, S. (1999) · Science · doi:10.1126/science.284.5412.313 · Cited by 609 · see citing works
Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.
Overturf, K., Al-Dhalimy, M., Ou, C. N., Finegold, M. J., & Grompe, M. (1997) · Europe PMC (PubMed Central) · Cited by 599 · see citing works
Goossens, V., Grooten, J., Vos, K. J. D., & Fiers, W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.18.8115 · Cited by 595 · see citing works
Replacement of Diseased Mouse Liver by Hepatic Cell Transplantation
Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D., & Brinster, R. L. (1994) · Science · doi:10.1126/science.8108734 · Cited by 577 · see citing works
The many faces of hepatocyte growth factor: from hepatopoiesis to hematopoiesis.
Zarnegar, R., & Michalopoulos, G. K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.5.1177 · Cited by 569 · see citing works
The Liver: Biology and Pathobiology
Worman, H. J. (1995) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(95)70120-6 · Cited by 548 · see citing works
c-Jun is essential for normal mouse development and hepatogenesis
Hilberg, F., Aguzzi, A., Howells, N., & Wagner, E. F. (1993) · Nature · doi:10.1038/365179a0 · Cited by 539 · see citing works
Chiasson, B. J., Tropepe, V., Morshead, C. M., & van der Kooy, D. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-11-04462.1999 · Cited by 528 · see citing works
Leist, M., Gantner, F., Bohlinger, I., Germann, P., Tiegs, G., & Wendel, A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.4.1778 · Cited by 492 · see citing works
NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.
Iimuro, Y., Nishiura, T., Hellerbrand, C., Behrns, K. E., Schoonhoven, R., Grisham, J. W., & Brenner, D. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci483 · Cited by 447 · see citing works
Transducers of life and death: TNF receptor superfamily and associated proteins.
Baker, S. J., & Reddy, E. P. (1996) · PubMed · Cited by 418 · see citing works
Complete hepatic regeneration after somatic deletion of an albumin-plasminogen activator transgene
Sandgren, E. P., Palmiter, R. D., Heckel, J. L., Daugherty, C. C., Brinster, R. L., & Degen, J. L. (1991) · Cell · doi:10.1016/0092-8674(91)90615-6 · Cited by 392 · see citing works
Hepatology: A Textbook of Liver Disease
O'Grady, J. (1997) · Gut · doi:10.1136/gut.40.4.562 · Cited by 391 · see citing works
Transcriptional control of liver regeneration
Taub, R. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.4.8647340 · Cited by 353 · see citing works
Rapid activation of the stat3 transcription complex in liver regeneration
Cressman, D. E., Diamond, R. H., & Taub, R. (1995) · Hepatology · doi:10.1002/hep.1840210531 · Cited by 314 · see citing works
Sequential protooncogene expression during rat liver regeneration.
Thompson, N. L., Mead, J. E., Braun, L., Goyette, M., Shank, P. R., & Fausto, N. (1986) · PubMed · Cited by 299 · see citing works
Self-citationWestwick, J. K., Weitzel, C., Minden, A., Karin, M., & Brenner, D. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47207-9 · Cited by 293 · see citing works
Roskams, T., Vos, R. D., Eyken, P. V., Myazaki, H., Damme, B. V., & Desmet, V. J. (1998) · Journal of Hepatology · doi:10.1016/s0168-8278(98)80065-2 · Cited by 287 · see citing works
Tumor Necrosis Factor Primes Hepatocytes for Dna Replication in the Rat
Webber, E. M., Bruix, J., Pierce, R. H., & Fausto, N. (1998) · Hepatology · doi:10.1002/hep.510280509 · Cited by 280 · see citing works
Self-citationMitosis and Apoptosis in the Liver of Interleukin–6-Deficient Mice After Partial Hepatectomy
Sakamoto, T., Liu, Z., Murase, N., Ezure, T., Yokomuro, S., Poli, V., & Demetris, A. J. (1999) · Hepatology · doi:10.1002/hep.510290244 · Cited by 276 · see citing works
Greenbaum, L. E., Li, W., Cressman, D. E., Peng, Y., Ciliberto, G., Poli, V, & Taub, R. (1998) · Journal of Clinical Investigation · doi:10.1172/jci3135 · Cited by 270 · see citing works
PRL-1, a Unique Nuclear Protein Tyrosine Phosphatase, Affects Cell Growth
Diamond, R. H., Cressman, D. E., Laz, T. M., Abrams, C. S., & Taub, R. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3752-3762.1994 · Cited by 265 · see citing works
Yamada, Y., Webber, E. M., Kirillova, I., Peschon, J. J., & Fausto, N. (1998) · Hepatology · doi:10.1002/hep.510280410 · Cited by 260 · see citing works
Self-citationImpaired liver regeneration in inducible nitric oxide synthasedeficient mice
Rai, R. M., Lee, F.-Y. J., Rosen, A., Yang, S. Q., Lin, H. Z., Koteish, A. A., Liew, F. Y., Zaragoza, C., Lowenstein, C. J., & Diehl, A. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13829 · Cited by 242 · see citing works
Regulation of signal transduction during liver regeneration
Diehl, A. M., & Rai, R. M. (1996) · The FASEB Journal · doi:10.1096/fasebj.10.2.8641555 · Cited by 229 · see citing works
In vivo response of hepatocytes to growth factors requires an initial priming stimulus
Webber, E. M., Godowski, P. J., & Fausto, N. (1994) · Hepatology · doi:10.1002/hep.1840190230 · Cited by 226 · see citing works
Self-citationGrowth Factor Dependence of Progression through G1 and S Phases of Adult Rat Hepatocytes in Vitro
Loyer, P., Cariou, S., Glaise, D., Bilodeau, M., Baffet, G., & Guguen‐Guillouzo, C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11484 · Cited by 224 · see citing works
Miyazawa, K., Shimomura, T., & Kitamura, N. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3615 · Cited by 216 · see citing works
Complete reconstitution of mouse liver with xenogeneic hepatocytes.
Rhim, J. A., Sandgren, E. P., Palmiter, R. D., & Brinster, R. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.11.4942 · Cited by 216 · see citing works
Yamada, Y., & Fausto, N. (1998) · Europe PMC (PubMed Central) · Cited by 208 · see citing works
Self-citationHaber, B. A., Mohn, K. L., Diamond, R. H., & Taub, R. A. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116332 · Cited by 202 · see citing works
Albrecht, J. H., Poon, R. Y. C., Ahonen, C. L., Rieland, B. M., Deng, C., & Crary, G. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201728 · Cited by 198 · see citing works
Extracellular matrix remodeling at the early stages of liver regeneration in the rat
Kim, T., Mars, W. M., Stolz, D. B., Petersen, B. E., & Michalopoulos, G. K. (1997) · Hepatology · doi:10.1002/hep.510260415 · Cited by 196 · see citing works
Hsu, J., Bravo, R., & Taub, R. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4654 · Cited by 187 · see citing works
(1999) · PubMed · Cited by 171 · see citing works
Generation of hepatocytes from oval cell precursors in culture.
Lázaro, C. A., Rhim, J. A., Yamada, Y., & Fausto, N. (1998) · PubMed · Cited by 170 · see citing works
Self-citationLee, J. F. Y., Li, Y., Zhu, H., Yang, S., Lin, H. Z., Trush, M. A., & Diehl, A. M. (1999) · Hepatology · doi:10.1002/hep.510290320 · Cited by 155 · see citing works
Tewari, M., Dobrzański, P., Mohn, K. L., Cressman, D. E., Hsu, J., Bravo, R., & Taub, R. A. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2898 · Cited by 150 · see citing works
Rana, B., Xie, Y., Mischoulon, D., Bucher, N. L. R., & Farmer, S. R. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.30.18123 · Cited by 149 · see citing works
Activation of Jun kinase is an early event in hepatic regeneration.
Westwick, J. K., Weitzel, C., Leffert, H. L., & Brenner, D. A. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117730 · Cited by 148 · see citing works
Webber, E. M., Fitzgerald, M. J., Brown, P. I., Bartlett, M. H., & Fausto, N. (1993) · Hepatology · doi:10.1002/hep.1840180622 · Cited by 145 · see citing works
Self-citationSelzner, M., Camargo, C. A., & Clavien, P. (1999) · Hepatology · doi:10.1002/hep.510300215 · Cited by 143 · see citing works
Sell, S. (1998) · Hepatology · doi:10.1002/hep.510270202 · Cited by 140 · see citing works
Taub, R., Greenbaum, L., & Peng, Y. (1999) · Seminars in Liver Disease · doi:10.1055/s-2007-1007104 · Cited by 139 · see citing works
Crosby, H. A., Hübscher, S. G., Fabris, L., Joplin, R., Sell, S., Kelly, D. A., & Strain, A. J. (1998) · Europe PMC (PubMed Central) · Cited by 136 · see citing works
Loyer, P., Glaise, D., Cariou, S., Baffet, G., Meijer, L., & Guguen‐Guillouzo, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41972-7 · Cited by 134 · see citing works
Liu, M.-L., Mars, W. M., Zarnegar, R., & Michalopoulos, G. K. (1994) · Hepatology · doi:10.1002/hep.1840190630 · Cited by 134 · see citing works
Kam, I., Lynch, S., Svanas, G. W., Todo, S., Polimeno, L., Francavilla, A., Penkrot, R. J., Takaya, S., Ericzon, B. G., Starzl, T. E., et al. (1987) · Hepatology · doi:10.1002/hep.1840070225 · Cited by 128 · see citing works
Morello, D., Fitzgerald, M. J., Babinet, C., & Fausto, N. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.6.3185 · Cited by 110 · see citing works
Self-citationThe Role of Cell Types in Hepatocarcinogenesis
Sirica, A. E. (1992) · Medical Entomology and Zoology · Cited by 109 · see citing works
Tzung, S.-P., Fausto, N., & Hockenbery, D. M. (1997) · PubMed · Cited by 102 · see citing works
Self-citationReflections on STAT3, STAT5, and STAT6 as fat STATs.
Darnell, J. E., Jr. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6221 · Cited by 96 · see citing works
Transient Induction of C–Jun During Hepatic Regeneration
Alcorn, J. A., Feitelberg, S. P., & Brenner, D. A. (1990) · Hepatology · doi:10.1002/hep.1840110602 · Cited by 86 · see citing works
Induction of replicative competence ("priming") in normal liver.
Mead, J. E., Braun, L., Martin, D. A., & Fausto, N. (1990) · PubMed · Cited by 84 · see citing works
Self-citation(1998) · Springer eBooks · doi:10.1007/978-94-011-4932-7 · Cited by 82 · see citing works
Leduc, E. H. (1949) · American Journal of Anatomy · doi:10.1002/aja.1000840304 · Cited by 66 · see citing works
Albrecht, J. H., Hoffman, J. S., Kren, B. T., & Steer, C. J. (1993) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1993.265.5.g857 · Cited by 65 · see citing works
Mitogenic Up-regulation of the PRL-1 Protein-tyrosine Phosphatase Gene by Egr-1
Peng, Y. L., Du, K., Ramirez, S., Diamond, R. H., & Taub, R. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.8.4513 · Cited by 61 · see citing works
Small-for-size liver transplanted into larger recipient: A model of hepatic regeneration
Francavilla, A., Zeng, Q.-H., Polimeno, L., et al. (1994) · Hepatology · doi:10.1002/hep.1840190131 · Cited by 59 · see citing works
Moolten, F. L., Oakman, N. J., & Bucher, N. L. R. (1970) · PubMed · Cited by 58 · see citing works
Aging and cancer: The role of stromal interactions with epithelial cells
Rinehart, C. A., & Torti, V. R. (1997) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199704)18:4 · Cited by 44 · see citing works
Kiso, S. (1995) · Hepatology · doi:10.1016/0270-9139(95)90168-x · Cited by 35 · see citing works
Fausto, N. (1997) · Europe PMC (PubMed Central) · Cited by 25 · see citing works
Self-citationTranscriptional Up-regulation of the Delayed Early GeneHRS/SRp40during Liver Regeneration
Du, K., Leu, J. I.-J., Peng, Y., & Taub, R. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.52.35208 · Cited by 21 · see citing works
Liver Regeneration and Carcinogenesis: Molecular and Cellular Mechanisms
Luisa, B. G. (1995) · Cited by 16 · see citing works
Phenotype modulation of human adult fibroblasts by oncogenes
Kopelovich, L., & Demian, S. E. (1996) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199603)15:3 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384 · see citing works
Liver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998 · see citing works
Mammalian circadian biology: elucidating genome-wide levels of temporal organization
Lowrey, P. L., & Takahashi, J. S. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.175925 · Cited by 976 · see citing works
Scar–free healing: from embryonic mechanisms to adult therapeutic intervention
Ferguson, M. W. J., & O'Kane, S. (2004) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2004.1475 · Cited by 812 · see citing works
Liver regeneration and repair: Hepatocytes, progenitor cells, and stem cells
Fausto, N. (2004) · Hepatology · doi:10.1002/hep.20214 · Cited by 720 · see citing works
Self-citationHepatic progenitor cells of biliary origin with liver repopulation capacity
Lu, W.-Y., Bird, T. G., Boulter, L., Tsuchiya, A., Cole, A. M., Hay, T., Guest, R. V., Wojtacha, D., Man, T. Y., Mackinnon, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3203 · Cited by 479 · see citing works
The proinflammatory mediators C3a and C5a are essential for liver regeneration
Strey, C. W., Markiewski, M., Mastellos, D., Tudoran, R., Spruce, L. A., Greenbaum, L. E., & Lambris, J. D. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20030374 · Cited by 436 · see citing works
TWEAK induces liver progenitor cell proliferation
Jakubowski, A., Ambrose, C., Parr, M., Lincecum, J. M., Wang, M. Z., Zheng, T. S., Browning, B., Michaelson, J. S., Baestcher, M., Wang, B., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23486 · Cited by 419 · see citing works
FXR: a metabolic regulator and cell protector
Wang, Y.-D., Chen, W.-D., Moore, D. D., & Huang, W. (2008) · Cell Research · doi:10.1038/cr.2008.289 · Cited by 389 · see citing works
A Mouse Model of Hepatocellular Carcinoma
Nicholes, K., Guillet, S., Tomlinson, E., Hillan, K., Wright, B., Frantz, G. D., Pham, T. A., Dillard-Telm, L., Tsai, S. P., Stephan, J.-P., et al. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)61177-7 · Cited by 359 · see citing works
The c‐myc Promoter: Still MysterY and Challenge
(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211 · see citing works
Interleukin 6 Is Important for Survival After Partial Hepatectomy in Mice
Blindenbacher, A., Wang, X., Langer, I., Savino, R., Terracciano, L., & Heim, M. H. (2003) · Hepatology · doi:10.1053/jhep.2003.50378 · Cited by 202 · see citing works
Stem cells versus plasticity in liver and pancreas regeneration
Kopp, J. L., Grompe, M., & Sander, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3309 · Cited by 176 · see citing works
Expression of suppressors of cytokine signaling during liver regeneration
Campbell, J. S., Prichard, L., Schaper, F., Schmitz, J., Stephenson-Famy, A., Rosenfeld, M. E., Argast, G. M., Heinrich, P. C., & Fausto, N. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11867 · Cited by 156 · see citing works
Self-citationGrowth hormone stimulates proliferation of old-aged regenerating liver through forkhead box m1b
Krupczak-Hollis, K. (2003) · Hepatology · doi:10.1053/jhep.2003.08052 · Cited by 115 · see citing works
Abshagen, K., Eipel, C., Kalff, J. C., Menger, M. D., & Vollmar, B. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00399.2006 · Cited by 107 · see citing works
c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409260102 · Cited by 104 · see citing works
Liver-Specific pRB Loss Results in Ectopic Cell Cycle Entry and Aberrant Ploidy
Mayhew, C. N., Bosco, E. E., Fox, S. R., Okaya, T., Tarapore, P., Schwemberger, S. J., Babcock, G. F., Lentsch, A. B., Fukasawa, K., & Knudsen, E. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4221 · Cited by 101 · see citing works
MAREK, C. J., TUCKER, S. J., KONSTANTINOU, D. K., ELRICK, L. J., HAEFNER, D., SIGALAS, C., MURRAY, G. I., GOODWIN, B., & WRIGHT, M. C. (2005) · Biochemical Journal · doi:10.1042/bj20041598 · Cited by 89 · see citing works
Nishiyama, K., Nakashima, H., Ikarashi, M., Kinoshita, M., Nakashima, M., Aosasa, S., Seki, S., & Yamamoto, J. (2015) · PLOS ONE · doi:10.1371/journal.pone.0136774 · Cited by 82 · see citing works
Longo, C. R., Patel, V. I., Shrikhande, G. V., Scali, S. T., Csizmadia, E., Daniel, S., Sun, D. W., Grey, S. T., Arvelo, M. B., & Ferran, C. (2005) · Hepatology · doi:10.1002/hep.20741 · Cited by 60 · see citing works
Autonomic regulation of liver regeneration after partial hepatectomy in mice
Ikeda, O., Ozaki, M., Murata, S., Matsuo, R., Nakano, Y., Watanabe, M., Hisakura, K., Myronovych, A., Kawasaki, T., Kohno, K., et al. (2009) · Journal of Surgical Research · doi:10.1016/j.jss.2008.02.059 · Cited by 32 · see citing works
The role of kupffer cells in rat liver regeneration revealed by cell‐specific microarray analysis
Xu, C., Jiang, Y., Zhang, L., Chang, C., Wang, G., Shi, R., & Yang, Y. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23348 · Cited by 31 · see citing works
Yang, W., Chen, Q., Xia, R., Zhang, Y., Shuai, L., Lai, J., You, X., Jiang, Y., Bie, P., Zhang, L., et al. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.05.026 · Cited by 30 · see citing works
Liver regeneration after partial hepatectomy: Triggers and mechanisms
Korchilava, B., Khachidze, T., Megrelishvili, N., Svanadze, L., Kakabadze, M., Tsomaia, K., Jintcharadze, M., & Kordzaia, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i7.107378 · Cited by 21 · see citing works
- Authors
- Fausto, N.
- Affiliations
- University of Washington (US)
- Corresponding author
- Fausto, Nelson
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 32
- Issue
- 1 Suppl
- Pages
- 19-31
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W4237329722
- Cited by
- 1,022
- References
- 79
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 18 · 2023: 20 · 2022: 25 · 2021: 18 · 2020: 19 · 2019: 16 · 2018: 24 · 2017: 35 · 2016: 36 · 2015: 26 · 2014: 37 · 2013: 34 · 2012: 54
- FWCI
- 9.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Surgery › Organ Transplantation Techniques and Outcomes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Keywords
- liver regeneration, partial hepatectomy, hepatocyte proliferation, apoptosis, stem-like cells, hepatocyte growth factor, transforming growth factor-alpha, epidermal growth factor, TNF-α, interleukin-6, reactive oxygen species, glutathione, NF-κB, STAT3, AP-1, C/EBPβ, extracellular matrix remodeling, cyclin D1, cell cycle, transgenic mouse model, knockout mouse models
- MeSH terms
- Animals, Cell Cycle, Cell Division, Growth Substances, Humans, Liver, Liver Regeneration, Stem Cells, Transcription Factors, Genes, Immediate-Early
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
