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c-Myc regulates cell size and ploidy but is not essential for postnatal proliferation in liver
Open accessAbstract
The c-Myc protein is a transcription factor implicated in the regulation of multiple biological processes, including cell proliferation, cell growth, and apoptosis. In vivo overexpression of c-myc is linked to tumor development in a number of mouse models. Here, we show that perinatal inactivation of c-Myc in liver causes disorganized organ architecture, decreased hepatocyte size, and cell ploidy. Furthermore, c-Myc appears to have distinct roles in proliferation in liver. Thus, postnatal hepatocyte proliferation does not require c-Myc, whereas it is necessary for liver regeneration in adult mice. These results show novel physiological functions of c-myc in liver development and hepatocyte proliferation and growth.
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“Although the CAR-driven c-Myc–Foxm1 axis has been implicated in promoting hepatocyte proliferation and regeneration in rodents,43,44”
From Constitutive Androstane Receptor Regulates Bile Acid Homeostasis and Metabolism During Liver Regeneration (2026) · cites this paper as [44]
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Metadata
- Authors
- Baena, E., Gandarillas, A., Vallespinós, M., Zanet, J., Bachs, O., Redondo, C., Fabregat, I., Martinez-A., C., & de Alborán, I. M.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Department of Immunology and Oncology, Centro Nacional de Biotecnología/Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Cantoblanco, E-28049 Madrid, Spain; Institut Universitaire de Recherche Clinique, Laboratoire de Dermatologie Moléculaire Unité Propre de Recherche de l'Enseignement Superieur EA3754, F-34093 Montpellier, France; Departament de Biologia Cellular i Anatomia Patologica, Institut d'Investigacions Biomediques August Pi i Sunyer, Facultat de Medicina,...
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-04-27
- Volume
- 102
- Issue
- 20
- Pages
- 7286-7291
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1129100
- OpenAlex
- W2046528425
- Cited by
- 104
- References
- 49
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 12 · 2022: 6 · 2021: 2 · 2020: 4 · 2018: 2 · 2017: 3 · 2016: 4 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 4.20
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- c-Myc, hepatocyte proliferation, liver regeneration, hepatocyte size, cell ploidy, liver development, cell growth, transcription factors
- MeSH terms
- Animals, Bromodeoxyuridine, Fluoresceins, Immunohistochemistry, Liver, Ploidies, Poly I-C, Polymerase Chain Reaction, Proto-Oncogene Proteins c-myc, DNA Primers, Mice, Knockout, Hepatocytes, Cell Size, Cell Proliferation, Mice
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