The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Near-infrared-emissive polymersomes: Self-assembled soft matter for in vivo optical imaging
Open accessAbstract
We demonstrate that synthetic soft materials can extend the utility of natural vesicles, from predominantly hydrophilic reservoirs to functional colloidal carriers that facilitate the biomedical application of large aqueous-insoluble compounds. Near-infrared (NIR)-emissive polymersomes (50-nm- to 50-μm-diameter polymer vesicles) were generated through cooperative self assembly of amphiphilic diblock copolymers and conjugated multi(porphyrin)-based NIR fluorophores (NIRFs). When compared with natural vesicles comprised of phospholipids, polymersomes were uniquely capable of incorporating and uniformly distributing numerous large hydrophobic NIRFs exclusively in their lamellar membranes. Within these sequestered compartments, long polymer chains regulate the mean fluorophore–fluorophore interspatial separation as well as the fluorophore-localized electronic environment. Porphyrin-based NIRFs manifest photophysical properties within the polymersomal matrix akin to those established for these high-emission dipole strength fluorophores in organic solvents, thereby yielding uniquely emissive vesicles. Furthermore, the total fluorescence emanating from the assemblies gives rise to a localized optical signal of sufficient intensity to penetrate through the dense tumor tissue of a live animal. Robust NIR-emissive polymersomes thus define a soft matter platform with exceptional potential to facilitate deep-tissue fluorescence-based imaging for in vivo diagnostic and drug-delivery applications.
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Cites
Diffusion of univalent ions across the lamellae of swollen phospholipids
Bangham, A. D., Standish, M. M., & Watkins, J. C. (1965) · Journal of Molecular Biology · doi:10.1016/s0022-2836(65)80093-6 · Cited by 4,664
On the origins of morphological complexity in block copolymer surfactants
Jain, S., & Bates, F. S. (2003) · Science · doi:10.1126/science.1082193 · Cited by 1,217
Self-citationPolymer vesicles in vivo: correlations with PEG molecular weight
Photos, P. J., Bacakova, L., Discher, B., Bates, F. S., & Discher, D. E. (2003) · Journal of Controlled Release · doi:10.1016/s0168-3659(03)00201-3 · Cited by 527
Self-citation
Cited by
Hong, G., Zou, Y., Antaris, A. L., Diao, S., Wu, D., Cheng, K., Zhang, X., Chen, C., Liu, B., He, Y., et al. (2014) · Nature Communications · doi:10.1038/ncomms5206 · Cited by 563
Polymeric nanostructured materials for biomedical applications
Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 363
Ghoroghchian, P. P., Li, G., Levine, D. H., Davis, K. P., Bates, F. S., Hammer, D. A., & Therien, M. J. (2006) · Macromolecules · doi:10.1021/ma0519009 · Cited by 266
Self-citationIndocyanine Green J Aggregates in Polymersomes for Near-Infrared Photoacoustic Imaging
Changalvaie, B., Han, S., Moaseri, E., Scaletti, F., Truong, L., Caplan, R., Cao, A., Bouchard, R., Truskett, T. M., Sokolov, K. V., et al. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b14519 · Cited by 93
Metadata
- Authors
- Ghoroghchian, P. P., Frail, P. R., Susumu, K., Blessington, D., Brannan, A. K., Bates, F. S., Chance, B., Hammer, D. A., & Therien, M. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-02-11
- Volume
- 102
- Issue
- 8
- Pages
- 2922-2927
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069111085
- Cited by
- 369
- References
- 3
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- green
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