The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
Open accessAbstract
Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages. Its production is stimulated by iron overload and by inflammation. It has been suggested that IL-6 is the only cytokine that stimulates hepcidin transcription. However, mice with targeted disruption of the gene encoding IL-6 (IL-6–/–) respond to endotoxin by increasing the expression of hepcidin transcripts in the liver. We show that incubating murine hepatocytes with IL-6, IL-1α, and IL-1β strongly stimulates hepcidin transcription. IL-10 has little or no stimulatory effect, and IFN-β inhibits transcription of hepcidin. All of the hepcidin stimulatory activity of macrophages from IL-6–/–mice can be accounted for by IL-1 that they secrete. Hepatocytes from IL-6–/–mice,hfe–/–mice, and mice with a hypomorphic transferrin receptor 2 mutation responded to IL-6 and IL-1 by up-regulating hepcidin transcription. Nitric oxide does not seem to be involved in the stimulation of hepcidin transcription by cytokines: aminoguanidine does not inhibit the stimulation of hepcidin transcription by cytokines. IL-1 may play a significant role in the anemia of inflammation by up-regulating hepcidin.
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Cites
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Hepcidin, a urinary antimicrobial peptide synthesized in the liver
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Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
Ganz, T. (2003) · Blood · doi:10.1182/blood-2003-03-0672 · Cited by 1,544
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
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Regulation of ferritin genes and protein
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Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis
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Cited by
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
Babitt, J. L., Huang, F. W., Wrighting, D. M., Xia, Y., Sidis, Y., Samad, T. A., Campagna, J. A., Chung, R. T., Schneyer, A. L., Woolf, C. J., et al. (2006) · Nature Genetics · doi:10.1038/ng1777 · Cited by 1,026
Regulation of Iron Metabolism by Hepcidin
Nemeth, E., & Ganz, T. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111303 · Cited by 756
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31370 · Cited by 639
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The serine protease TMPRSS6 is required to sense iron deficiency
Du, X., She, E., Gelbart, T., Truksa, J., Lee, P., Xia, Y., Khovananth, K., Mudd, S., Mann, N., Moresco, E. M. Y., et al. (2008) · Science · doi:10.1126/science.1157121 · Cited by 578
Self-citation
Metadata
- Authors
- Lee, P., Peng, H., Gelbart, T., Wang, L., & Beutler, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-01-31
- Volume
- 102
- Issue
- 6
- Pages
- 1906-1910
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1992880469
- Cited by
- 543
- References
- 9
- FWCI
- 21.60
- Type
- journal article
- Language
- en
- Open access
- green
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