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Cited by 543

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Regulation of hepcidin transcription by interleukin-1 and interleukin-6

Open access
Lee, Pauline, Peng, Hongfan, Gelbart, Terri, Wang, Lei, Beutler, Ernest·2005·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0409808102
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Abstract

Hepcidin is a peptide that regulates iron homeostasis by inhibiting iron absorption by the small intestine and release of iron from macrophages. Its production is stimulated by iron overload and by inflammation. It has been suggested that IL-6 is the only cytokine that stimulates hepcidin transcription. However, mice with targeted disruption of the gene encoding IL-6 (IL-6–/–) respond to endotoxin by increasing the expression of hepcidin transcripts in the liver. We show that incubating murine hepatocytes with IL-6, IL-1α, and IL-1β strongly stimulates hepcidin transcription. IL-10 has little or no stimulatory effect, and IFN-β inhibits transcription of hepcidin. All of the hepcidin stimulatory activity of macrophages from IL-6–/–mice can be accounted for by IL-1 that they secrete. Hepatocytes from IL-6–/–mice,hfe–/–mice, and mice with a hypomorphic transferrin receptor 2 mutation responded to IL-6 and IL-1 by up-regulating hepcidin transcription. Nitric oxide does not seem to be involved in the stimulation of hepcidin transcription by cytokines: aminoguanidine does not inhibit the stimulation of hepcidin transcription by cytokines. IL-1 may play a significant role in the anemia of inflammation by up-regulating hepcidin.

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Show all 9 references

Research works printed but not linked: 9

  1. 10.1182/blood-2002-10-3235 · DOI · Paper page
  2. 10.1136/ard.47.12.972 · DOI
  3. 10.1097/00062752-200407000-00004 · DOI
  4. 10.1182/blood-2004-08-3042 · DOI · Paper page
  5. 10.1038/ng1350 · DOI
  6. 10.1111/j.1365-2141.2004.05044.x · DOI
  7. Geller, D. A., de Vera, M. E., Russell, D. A., Shapiro, R. A., Nussler, A. K., Simmons, R. L. & Billiar, T. R. (1995) J. Immunol. 155, 4890–4898.7594493 · DOI
  8. 10.1152/ajprenal.1998.274.4.F673 · DOI
  9. Alvarez-Hernandez, X., Liceaga, J., McKay, I. C. & Brock, J. H. (1989) Lab. Invest. 61, 319–322.2788773

Cited by

Metadata

Authors
Lee, P., Peng, H., Gelbart, T., Wang, L., & Beutler, E.
Venue
Proceedings of the National Academy of Sciences
Publisher
Proceedings of the National Academy of Sciences
Published
2005-01-31
Volume
102
Issue
6
Pages
1906-1910
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
DOI
10.1073/pnas.0409808102
OpenAlex
W1992880469
Cited by
543
References
9
FWCI
21.60
Type
journal article
Language
en
Open access
green

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