Successively activatable ultrasensitive probe for imaging tumour acidity and hypoxia
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Proof of concept for synthetic biomarkers has been shown in mice by sequential activation through tumour acidity and hypoxia, enabling imaging of tumours as small as 1 mm.
“sequential activation by tumour acidity and hypoxia for ultrasensitive imaging detection of tumours as small as 1 mm in mice,90”
From Early detection of pancreatic cancer (2020) · cites this paper as [90]
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Early detection of pancreatic cancer
Pereira, S. P., Oldfield, L., Ney, A., Hart, P. A., Keane, M. G., Pandol, S. J., Li, D., Greenhalf, W., Jeon, C. Y., Koay, E. J., et al. (2020) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(19)30416-9 · Cited by 482 · see citing works
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Williams, R. M., Lee, C., Galassi, T. V., Harvey, J. D., Leicher, R., Sirenko, M., Dorso, M. A., Shah, J., Olvera, N., Dao, F., et al. (2018) · Science Advances · doi:10.1126/sciadv.aaq1090 · Cited by 183 · see citing works
- Authors
- Zheng, X., Mao, H., Huo, D., Wu, W., Liu, B., & Jiang, X.
- Affiliations
- Nanjing University (CN)
- Emory University (US)
- Nanjing Drum Tower Hospital (CN)
- Corresponding author
- Jiang, Xiqun
- Venue
- Nature Biomedical Engineering
- Published
- 2017-04-10
- Volume
- 1
- Issue
- 4
- ISSN
- 2157-846X (ISSN-L)
- OpenAlex
- W2606689723
- Cited by
- 210
- References
- 42
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 16 · 2023: 24 · 2022: 33 · 2021: 30 · 2020: 39 · 2019: 24 · 2018: 16 · 2017: 8
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature Biomedical Engineering (publishedVersion)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Molecular Sensors and Ion Detection
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Materials Chemistry › Luminescence and Fluorescent Materials
- Keywords
- tumor acidosis, tumor hypoxia, near-infrared imaging, iridium(III) complexes, polyethylene glycol conjugates, signal propagation, molecular imaging probes
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