The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
Open accessAbstract
Mismatch repair (MMR) proteins contribute to genome integrity by correcting replication errors. In higher eukaryotes, MMR proteins also regulate the cellular response to DNA lesions such as oxidized, alkylated, or crosslinked bases. Previous studies have linked MMR proteins to the activation of apoptosis through p53-dependent and p53-independent mechanisms. MMR-deficient cells exhibit variable defects in the induction of p53 and its related p73, which are activators of apoptosis. However, the specific role of each MMR protein in the regulation of apoptosis has not been determined. Here, we describe an interaction between PMS2, an MMR protein, and p73. This interaction causes the stabilization of p73 and the redistribution of PMS2 to the nuclear compartment. Exposure to cisplatin enhances the association between PMS2 and p73. Moreover, stimulation of the p73 proapoptotic function by cisplatin requires PMS2. These results suggest that PMS2 contributes to genome integrity not only through DNA repair but also by enhancing DNA damage-induced apoptosis.
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Cites
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Wang, Y., Cortez, D., Yazdi, P., Neff, N., Elledge, S. J., & Qin, J. (2000) · Genes & Development · doi:10.1101/gad.14.8.927 · Cited by 1,221
p73 is a human p53-related protein that can induce apoptosis
Jost, C. A., Marin, M. C., & Jr, W. G. K. (1997) · Nature · doi:10.1038/38298 · Cited by 948
The mismatch repair system is required for S-phase checkpoint activation
Brown, K. D., Rathi, A., Kamath, R., Beardsley, D. I., Zhan, Q., Mannino, J. L., & Baskaran, R. (2003) · Nature Genetics · doi:10.1038/ng1052 · Cited by 206
Cited by
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,370
Kunkel, T. A., & Erie, D. A. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.74.082803.133243 · Cited by 1,367
DNA Mismatch Repair: Functions and Mechanisms
Iyer, R. R., Pluciennik, A., Burdett, V., & Modrich, P. L. (2006) · Chemical Reviews · doi:10.1021/cr0404794 · Cited by 905
Mismatch repair and DNA damage signalling
Stojic, L., Brun, R., & Jiricny, J. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.006 · Cited by 396
DNA mismatch repair and the DNA damage response
Li, Z., Pearlman, A. H., & Hsieh, P. (2016) · DNA Repair · doi:10.1016/j.dnarep.2015.11.019 · Cited by 307
Metadata
- Authors
- Shimodaira, H., Yoshioka-Yamashita, A., Kolodner, R. D., & Wang, J. Y. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-02-24
- Volume
- 100
- Issue
- 5
- Pages
- 2420-2425
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2019109254
- Cited by
- 168
- References
- 4
- FWCI
- 6.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Shimodaira, H., Yoshioka-Yamashita, A., Kolodner, R. D., & Wang, J. Y. J. (2003). Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0438031100
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