Cited by 948Cancer-related Molecular PathwaysCell death mechanisms and regulationHeat shock proteins research

p73 is a human p53-related protein that can induce apoptosis

Jost, Christine A., Marin, Maria C., Jr, William G. Kaelin·1997·Nature

Abstract

The protein p53 is the most frequently mutated tumour suppressor to be identified so far in human cancers. The ability of p53 to inhibit cell growth is due, at least in part, to its ability to bind to specific DNA sequences and activate the transcription of target genes such as that encoding the cell-cycle inhibitor p21Waf1/Cip1 . A gene has recently been identified that is predicted to encode a protein with significant amino-acid sequence similarity to p53. In particular, each of the p53 amino-acid residues implicated in direct sequence-specific DNA binding is conserved in this protein. This gene, called p73, maps to the short arm of chromosome 1, and is found in a region that is frequently deleted in neuroblastomas. Here we show that p73 can, at least when overproduced, activate the transcription of p53-responsive genes and inhibit cell growth in a p53-like manner by inducing apoptosis (programmed cell death).

Integrity signals

Registry

Crossref · 10.1038/38298

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

1 of the 25 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Jost, C. A., Marin, M. C., & Jr, W. G. K.
Affiliations
Harvard University (US)
Venue
Nature
Published
1997-09-11
Volume
389
Issue
6647
Pages
191-194
ISSN
  • 0028-0836 (ISSN-L)
  • 1476-4687
OpenAlex
W1675096266
Cited by
948
References
25
Citations by year
2026: 4 · 2025: 4 · 2024: 13 · 2023: 7 · 2022: 15 · 2021: 18 · 2020: 13 · 2019: 13 · 2018: 11 · 2017: 15 · 2016: 18 · 2015: 20 · 2014: 19 · 2013: 25 · 2012: 26
FWCI
34.25
Type
journal article
Language
en
Update notices
erratum (1999-06-24)
Open access
closed
Locations
  • Nature (publishedVersion)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Keywords
p73, p53, tumor suppressor proteins, apoptosis, transcriptional activation, cell growth inhibition, neuroblastoma, chromosome 1p deletion, p21, programmed cell death
MeSH terms
Tumor Protein p73, Cell Division, Cell Line, Chromosome Mapping, Chromosomes, Human, Pair 1, DNA-Binding Proteins, Growth Inhibitors, Humans, Molecular Sequence Data, Neuroblastoma, Nuclear Proteins, Plasmids, Tumor Cells, Cultured, Chloramphenicol O-Acetyltransferase, Transcriptional Activation, Genes, Tumor Suppressor, Tumor Suppressor Protein p53, Cyclins, Mutagenesis, Site-Directed, Apoptosis, Tumor Suppressor Proteins, Cyclin-Dependent Kinase Inhibitor p21

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review