The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Contingent gene regulatory networks and B cell fate specification
Open accessAbstract
The B cell developmental pathway represents a leading system for the analysis of regulatory circuits that orchestrate cell fate specification and commitment. Considerable progress has been achieved within the past decade in the identification and genetic analysis of various regulatory components. These components include the transcription factors PU.1, Ikaros, Bcl11a, E2A, EBF, and Pax-5, as well as the cytokine receptors Flk2 and IL-7R. Experimental evidence of connectivity among the regulatory components is used to assemble sequentially acting and contingent gene regulatory networks. Transient signaling inputs, self-sustaining positive feedback loops, and crossantagonism among alternate cell fate determinants are key features of the proposed networks that instruct the development of B lymphocyte precursors from hematopoietic stem cells.
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Citations
Cites
Regulation of B lymphocyte and macrophage development by graded expression of PU.1
DeKoter, R. P., & Singh, H. (2000) · Science · doi:10.1126/science.288.5470.1439 · Cited by 749
Self-citationMyeloid or Lymphoid Promiscuity as a Critical Step in Hematopoietic Lineage Commitment
Miyamoto, T., Iwasaki, H., Reizis, B., Ye, M., Graf, T., Weissman, I. L., & Akashi, K. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00201-0 · Cited by 415
Bcl11a is essential for normal lymphoid development
Liu, P., Keller, J. R., Ortiz, M., Tessarollo, L., Rachel, R. A., Nakamura, T., Jenkins, N. A., & Copeland, N. G. (2003) · Nature Immunology · doi:10.1038/ni925 · Cited by 351
Miller, J. P., Izon, D., DeMuth, W., Gerstein, R., Bhandoola, A., & Allman, D. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020784 · Cited by 198
Cited by
Gene Regulatory Networks and the Evolution of Animal Body Plans
Davidson, E. H., & Erwin, D. H. (2006) · Science · doi:10.1126/science.1113832 · Cited by 1,207
Forcing cells to change lineages
Graf, T., & Enver, T. (2009) · Nature · doi:10.1038/nature08533 · Cited by 899
Gene regulatory networks for development
Levine, M., & Davidson, E. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408031102 · Cited by 796
GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
Kouros-Mehr, H., Slorach, E. M., Sternlicht, M. D., & Werb, Z. (2006) · Cell · doi:10.1016/j.cell.2006.09.048 · Cited by 688
Multilineage Transcriptional Priming and Determination of Alternate Hematopoietic Cell Fates
Laslo, P., Spooner, C. J., Warmflash, A., Lancki, D. W., Lee, H.-J., Sciammas, R., Gantner, B. N., Dinner, A. R., & Singh, H. (2006) · Cell · doi:10.1016/j.cell.2006.06.052 · Cited by 632
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Metadata
- Authors
- Singh, H., Medina, K. L., & Pongubala, J. M. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-03-23
- Volume
- 102
- Issue
- 14
- Pages
- 4949-4953
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2066088658
- Cited by
- 189
- References
- 4
- FWCI
- 8.16
- Type
- journal article
- Language
- en
- Open access
- green
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