The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae : Genetic requirements
Open accessAbstract
Natural competence for genetic transformation is the best-characterized feature of the major human pathogen Streptococcus pneumoniae . Recent studies have shown the virulence of competence-deficient mutants to be attenuated, but the nature of the connection between competence and virulence remained unknown. Here we document the release, triggered by competent cells, of virulence factors (e.g., the cytolytic toxin pneumolysin) from noncompetent cells. This phenomenon, which we name allolysis, involves a previously undescribed bacteriocin system consisting of a two-peptide bacteriocin, CibAB, and its immunity factor, CibC; the major autolysin, LytA, and lysozyme, LytC; and a proposed new amidase, CbpD. We show that CibAB are absolutely required for allolysis, whereas LytA and LytC can be supplied either by the competent cells or by the targeted cells. We propose that allolysis constitutes a competence-programmed mechanism of predation of noncompetent cells, which benefits to the competent cells and contributes to virulence by coordinating the release of virulence factors.
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Cited by
Bassler, B. L., & Losick, R. (2006) · Cell · doi:10.1016/j.cell.2006.04.001 · Cited by 983
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Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae
Prudhomme, M., Attaiech, L., Sanchez, G., Martin, B., & Claverys, J.-P. (2006) · Science · doi:10.1126/science.1127912 · Cited by 451
Self-citationMolecular control of bacterial death and lysis
Rice, K. C., & Bayles, K. W. (2008) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00030-07 · Cited by 362
Vermassen, A., Leroy, S., Talon, R., Provot, C., Popowska, M., & Desvaux, M. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.00331 · Cited by 348
Metadata
- Authors
- Guiral, S., Mitchell, T. J., Martin, B., & Claverys, J.-P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-05-31
- Volume
- 102
- Issue
- 24
- Pages
- 8710-8715
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1641873288
- Cited by
- 298
- References
- 48
- FWCI
- 10.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Guiral, S., Mitchell, T. J., Martin, B., & Claverys, J.-P. (2005). Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae : Genetic requirements. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0500879102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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