The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae
Abstract
Natural transformation is a widespread mechanism for genetic exchange in bacteria. Aminoglycoside and fluoroquinolone antibiotics, as well as mitomycin C, a DNA-damaging agent, induced transformation in Streptococcus pneumoniae . This induction required an intact competence regulatory cascade. Furthermore, mitomycin C induction of recA was strictly dependent on the development of competence. In response to antibiotic stress, S. pneumoniae , which lacks an SOS-like system, exhibited genetic transformation. The design of antibiotherapy should take into consideration this potential of a major human pathogen to increase its rate of genetic exchange in response to antibiotics.
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Cites
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Cited by
Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer
von Wintersdorff, C. J. H., Penders, J., van Niekerk, J. M., Mills, N. D., Majumder, S., van Alphen, L. B., Savelkoul, P. H. M., & Wolffs, P. F. G. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00173 · Cited by 1,707
Stress Physiology of Lactic Acid Bacteria.
Papadimitriou, K., Alegría, Á., Bron, P. A., de Angelis, M., Gobbetti, M., Kleerebezem, M., Lemos, J. A., Linares, D. M., Ross, P., Stanton, C., et al. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00076-15 · Cited by 914
Antibiotic perturbations to the gut microbiome
Fishbein, S. R. S., Mahmud, B., & Dantas, G. (2023) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00933-y · Cited by 440
Slager, J., Kjos, M., Attaiech, L., & Veening, J.-W. (2014) · Cell · doi:10.1016/j.cell.2014.01.068 · Cited by 237
Self-citationQuorum Sensing Regulation of Competence and Bacteriocins in Streptococcus pneumoniae and mutans
Shanker, E., & Federle, M. (2017) · Genes · doi:10.3390/genes8010015 · Cited by 176
Metadata
- Authors
- Prudhomme, M., Attaiech, L., Sanchez, G., Martin, B., & Claverys, J.-P.
- Venue
- Science
- Published
- 2006-07-07
- Volume
- 313
- Issue
- 5783
- Pages
- 89-92
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979477952
- Cited by
- 451
- References
- 21
- FWCI
- 10.07
- Type
- journal article
- Language
- en
- Open access
- closed
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- Prudhomme, M., Attaiech, L., Sanchez, G., Martin, B., & Claverys, J.-P. (2006). Antibiotic Stress Induces Genetic Transformability in the Human Pathogen Streptococcus pneumoniae. Science. https://doi.org/10.1126/science.1127912
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
