The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Hydrogen peroxide generated extracellularly by receptor–ligand interaction facilitates cell signaling
Open accessAbstract
Reactive oxygen species (ROS) are key components of postreceptor intracellular signaling pathways; however, the role of ROS in signal initiation is uncertain. We discovered that receptor–ligand interaction caused the generation of hydrogen peroxide (H 2 O 2 ). Using members of the hematopoietin receptor superfamily, as well as EGF receptor, we show that H 2 O 2 is generated by specific receptor–ligand interaction in cells and in cell-free systems. With cognate ligand, the extracellular domain of the receptor was sufficient for H 2 O 2 generation. We also found that production of H 2 O 2 was diminished in a granulocyte–macrophage colony-stimulating factor receptor mutant unable to bind ligand. Exogenously added H 2 O 2 induced signaling in the absence of ligand, whereas catalase and a membrane-bound peroxiredoxin inhibited ligand-dependent signaling. Our results suggest that H 2 O 2 produced by receptor–ligand interaction is involved as a chemical mediator that facilitates cell signaling.
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Signal Transduction and the Control of Gene Expression
Brivanlou, A. H., & Darnell, J. E. (2002) · Science · doi:10.1126/science.1066355 · Cited by 699
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
Jackson, S. H., Devadas, S., Kwon, J., Pinto, L. A., & Williams, M. S. (2004) · Nature Immunology · doi:10.1038/ni1096 · Cited by 457
Amplification of B cell antigen receptor signaling by a Syk/ITAM positive feedback loop
Rolli, V., Gallwitz, M., Wossning, T., Flemming, A., Schamel, W. W. A., Zürn, C., & Reth, M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00739-6 · Cited by 331
Cited by
Hydrogen peroxide sensing and signaling
Veal, E. A., Day, A. M., & Morgan, B. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.016 · Cited by 1,604
Lubos, E., Loscalzo, J., & Handy, D. E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3586 · Cited by 1,280
Reactive Oxygen Species-Induced Activation of the MAP Kinase Signaling Pathways
McCubrey, J. A., LaHair, M. M., & Franklin, R. A. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1775 · Cited by 803
Wang, T., Zhu, H., Zhuo, J., Zhu, Z., Papakonstantinou, P., Lubarsky, G., Lin, J., & Li, M. (2013) · Analytical Chemistry · doi:10.1021/ac402114c · Cited by 462
A redox cycle within the cell cycle: ring in the old with the new
Menon, S. G., & Goswami, P. C. (2007) · Oncogene · doi:10.1038/sj.onc.1209895 · Cited by 294
Metadata
- Authors
- DeYulia, G. J., Cárcamo, J. M., Bórquez-Ojeda, O., Shelton, C. C., & Golde, D. W.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-03-28
- Volume
- 102
- Issue
- 14
- Pages
- 5044-5049
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2054165134
- Cited by
- 159
- References
- 3
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- green
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- DeYulia, G. J., Cárcamo, J. M., Bórquez-Ojeda, O., Shelton, C. C., & Golde, D. W. (2005). Hydrogen peroxide generated extracellularly by receptor–ligand interaction facilitates cell signaling. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0501154102
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