T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

Jackson, Sharon H; Devadas, Satish; Kwon, Jaeyul; Pinto, Ligia A; Williams, Mark S

doi:10.1038/ni1096

Cited by 457Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressT-cell and B-cell Immunology

T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

Jackson, Sharon H, Devadas, Satish, Kwon, Jaeyul, Pinto, Ligia A, Williams, Mark S·2004·Nature Immunology

DOI 10.1038/ni1096

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Abstract

T cell receptor (TCR) stimulation induces rapid generation of reactive oxygen species, although the mechanisms for this are unclear. Here we found that T cells expressed a functional phagocyte-type nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. TCR crosslinking induced oxidase activation through the recruitment of preformed Fas ligand and Fas. TCR stimulation induced three separable events generating reactive oxygen species: rapid hydrogen peroxide production independent of Fas or NADPH oxidase; sustained hydrogen peroxide production dependent on both Fas and NADPH oxidase; and delayed superoxide production that was dependent on Fas ligand and Fas yet independent of NADPH oxidase. NADPH oxidase-deficient T cells showed enhanced activation of the kinase Erk and a relative increase in T helper type 1 cytokine secretion. Thus, mature T cells express a phagocyte-type NADPH oxidase that regulates elements of TCR signaling.

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Authors: Jackson, S. H., Devadas, S., Kwon, J., Pinto, L. A., & Williams, M. S.
Affiliations: National Institutes of Health (US)
American Red Cross (US)
University of Maryland, Baltimore (US)
Corresponding author: Williams, Mark S
ORCID: Jackson, Sharon H
Devadas, Satish
Kwon, Jaeyul
Venue: Nature Immunology
Publisher: Springer Science and Business Media LLC
Published: 2004-07-18
Volume: 5
Issue: 8
Pages: 818-827
ISSN: 1529-2908 (ISSN-L)
1529-2916
DOI: 10.1038/ni1096
OpenAlex: W2005299533
Cited by: 457
References: 54
Citations by year: 2026: 14 · 2025: 10 · 2024: 19 · 2023: 20 · 2022: 24 · 2021: 29 · 2020: 31 · 2019: 16 · 2018: 23 · 2017: 23 · 2016: 16 · 2015: 24 · 2014: 17 · 2013: 27 · 2012: 25
FWCI: 7.43
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: T cell receptor signaling, NADPH oxidase, reactive oxygen species, Fas ligand, Fas, hydrogen peroxide, superoxide, ERK kinase, T cell activation, phagocyte NADPH oxidase
MeSH terms: Animals, Cells, Cultured, Humans, Lymphocyte Activation, Membrane Glycoproteins, Receptors, Antigen, T-Cell, T-Lymphocytes, Immunoblotting, Signal Transduction, Reactive Oxygen Species, fas Receptor, NADPH Oxidases, Reverse Transcriptase Polymerase Chain Reaction, Fas Ligand Protein

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T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation

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