Signal Transduction and the Control of Gene Expression
Abstract
More than 2000 transcription factors are encoded in the human genome. Such proteins have often been classified according to common structural elements. But because transcription factors evolved in the service of biologic function, we propose an alternative grouping of eukaryotic transcription factors on the basis of characteristics that describe their roles within cellular regulatory circuits.
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Regulation of DNA binding by phosphorylation of sequence-specific transcription factors has been well documented in several cases and can act both positively and negatively.
“Such regulation of DNA binding by phosphorylation of sequence-specific transcription factors has been well documented in several cases and can act both positively and negatively (3).”
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- Authors
- Brivanlou, A. H., & Darnell, J. E.
- Affiliations
- Rockefeller University (US)
- Laboratory of Molecular Cell Biology, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
- ORCID
- Brivanlou, Ali H.
- Venue
- Science
- Published
- 2002-02
- Volume
- 295
- Issue
- 5556
- Pages
- 813-818
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2098664089
- Cited by
- 699
- References
- 8
- Citations by year
- 2026: 4 · 2025: 13 · 2024: 19 · 2023: 27 · 2022: 20 · 2021: 12 · 2020: 17 · 2019: 16 · 2018: 22 · 2017: 12 · 2016: 17 · 2015: 15 · 2014: 37 · 2013: 33 · 2012: 53
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ey012370-05, 2r01gm032105-07)
- National Eye Institute (1RO1EY12370-03)
- National Institute of Allergy and Infectious Diseases (AI 34420, R01AI032489, AI32489)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (2RO1HD/GM32105-06A1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- transcription factors, signal transduction, gene expression regulation, eukaryotic transcription factors
- MeSH terms
- Animals, Cell Nucleus, Cytoplasm, DNA, DNA-Binding Proteins, Gene Expression Regulation, Phosphorylation, Phosphoserine, Receptors, Cell Surface, Transcription Factors, Transcription, Genetic, Second Messenger Systems, Signal Transduction
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