The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Patellamide A and C biosynthesis by a microcin-like pathway in Prochloron didemni , the cyanobacterial symbiont of Lissoclinum patella
Open accessAbstract
Prochloron spp. are obligate cyanobacterial symbionts of many didemnid family ascidians. It has been proposed that the cyclic peptides of the patellamide class found in didemnid extracts are synthesized by Prochloron spp., but studies in which host and symbiont cells are separated and chemically analyzed to identify the biosynthetic source have yielded inconclusive results. As part of the Prochloron didemni sequencing project, we identified patellamide biosynthetic genes and confirmed their function by heterologous expression of the whole pathway in Escherichia coli . The primary sequence of patellamides A and C is encoded on a single ORF that resembles a precursor peptide. We propose that this prepatellamide is heterocyclized to form thiazole and oxazoline rings, and the peptide is cleaved to yield the two cyclic patellamides, A and C. This work represents the full sequencing and functional expression of a marine natural-product pathway from an obligate symbiont. In addition, a related cluster was identified in Trichodesmium erythraeum IMS101, an important bloom-forming cyanobacterium.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Pfam Protein Families Database
Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,075
Improved microbial gene identification with GLIMMER
Delcher, A. L. (1999) · Nucleic Acids Research · doi:10.1093/nar/27.23.4636 · Cited by 2,493
Besemer, J., Lomsadze, A., & Borodovsky, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.12.2607 · Cited by 2,343
Complete Genome Sequence of a Virulent Isolate of Streptococcus pneumoniae
Tettelin, H., Nelson, K. E., Paulsen, I. T., Eisen, J. A., Read, T. D., Peterson, S. N., Heidelberg, J. F., DeBoy, R. T., Haft, D. H., Dodson, R. J., et al. (2001) · Science · doi:10.1126/science.1061217 · Cited by 1,341
Self-citationThe Pfam Protein Families Database
Bateman, A. G., Birney, E., Cerruti, L., Durbin, R. M., Etwiller, L., Eddy, S. R., Griffiths‐Jones, S., Howe, K., Marshall, M. S., & Sonnhammer, E. L. L. (2002) · PubMed Central · Cited by 764
Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials
Newman, D. J., & Cragg, G. M. L. (2004) · Journal of Natural Products · doi:10.1021/np040031y · Cited by 758
Biosynthesis and Mode of Action of Lantibiotics
Chatterjee, C., Paul, M., Xie, L., & van der Donk, W. A. (2005) · Chemical Reviews · doi:10.1021/cr030105v · Cited by 740
Marine natural products as anticancer drugs
Simmons, T. L., Andrianasolo, E., McPhail, K., Flatt, P., & Gerwick, W. H. (2005) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.333.4.2 · Cited by 597
Piel, J., Hui, D., Wen, G., Butzke, D., Platzer, M., Fusetani, N., & Matsunaga, S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405976101 · Cited by 543
Prepeptide sequence of epidermin, a ribosomally synthesized antibiotic with four sulphide-rings
Schnell, N. F., Entian, K., Schneider, U., Götz, F., Zähner, H., Kellner, R., & Jung, G. (1988) · Nature · doi:10.1038/333276a0 · Cited by 538
Research works printed but not linked: 5
- Faulkner, D. J., He, H. Y., Unson, M. D. & Bewley, C. A. (1993) Gazz. Chim. Ital. 123, 301-307.
- Sings, H. L. & Rinehart, K. L. (1996) J. Ind. Microbiol. 17, 385-396.
- Haygood, M. G., Schmidt, E. W., Davidson, S. K. & Faulkner, D. J. (1999) J. Mol. Microbiol. Biotechnol. 1, 33-34.10941782
- Kline, T. C. & Lewin, R. A. (1999) Symbiosis 26, 193-198.
- Swift, H. & Robertson, D. L. (1991) Symbiosis 10, 95-113.
Cited by
Sorted by citations
Items 301–400 of 569
A Genomic View of Secondary Metabolite Production in Cyanobacteria
Méjean, A., & Ploux, O. (2012) · Advances in botanical research · doi:10.1016/b978-0-12-394313-2.00006-8 · Cited by 30
Comba, P., Dovalil, N., Hanson, G. R., & Linti, G. W. (2011) · Inorganic Chemistry · doi:10.1021/ic2004694 · Cited by 30
Onaka, H. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90263 · Cited by 30
Synthesis of Hybrid Cyclopeptides through Enzymatic Macrocyclization
Oueis, E., Nardone, B., Jaspars, M., Westwood, N. J., & Naismith, J. H. (2016) · ChemistryOpen · doi:10.1002/open.201600134 · Cited by 29
Goto, Y., & Suga, H. (2018) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2018.06.014 · Cited by 29
Malloy, K. L., Suyama, T. L., Engene, N., Debonsi, H. M., Cao, Z., Matainaho, T. K., Spadafora, C., Murray, T. F., & Gerwick, W. H. (2011) · Journal of Natural Products · doi:10.1021/np200611f · Cited by 29
The hidden diversity of ribosomal peptide natural products
Schmidt, E. W. (2010) · BMC Biology · doi:10.1186/1741-7007-8-83 · Cited by 29
Self-citationCyanophycin— an Ideal Bacterial Nitrogen Storage Material with Unique Chemical Properties
Obst, M., & Steinbüchel, A. (2006) · Springer eBooks · doi:10.1007/3-540-33774-1_7 · Cited by 28
Bypassing the proline/thiazoline requirement of the macrocyclase PatG
Oueis, E., Stevenson, H., Jaspars, M., Westwood, N. J., & Naismith, J. H. (2017) · Chemical Communications · doi:10.1039/c7cc06550g · Cited by 28
Recent advances in the biosynthesis of RiPPs from multicore-containing precursor peptides
Rubin, G. M., & Ding, Y. (2020) · Journal of Industrial Microbiology & Biotechnology · doi:10.1007/s10295-020-02289-1 · Cited by 29
Microbiome Variability across the Native and Invasive Ranges of the Ascidian Clavelina oblonga
Goddard‐Dwyer, M., López‐Legentil, S., & Erwin, P. M. (2020) · Applied and Environmental Microbiology · doi:10.1128/aem.02233-20 · Cited by 28
Temporal stability of bacterial symbionts in a temperate ascidian
López‐Legentil, S., Turón, X., Espluga, R., & Erwin, P. M. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01022 · Cited by 28
Solution Structure of the Leader Sequence of the Patellamide Precursor Peptide, PatE 1–34
Houssen, W. E., Wright, S. H., Kalverda, A. P., Thompson, G. S., Kelly, S. M., & Jaspars, M. (2010) · ChemBioChem · doi:10.1002/cbic.201000305 · Cited by 29
An Enzymatic Route to Selenazolines
Koehnke, J., Morawitz, F., Bent, A. F., Houssen, W. E., Shirran, S. L., Fuszard, M. A., Smellie, I. A., Botting, C. H., Smith, M. C. M., Jaspars, M., et al. (2013) · ChemBioChem · doi:10.1002/cbic.201300037 · Cited by 29
Bioactive and Novel Chemicals from Microalgae
Coates, R. C., Trentacoste, E. M., & Gerwick, W. H. (2013) · Wiley eBooks · doi:10.1002/9781118567166.ch26 · Cited by 29
Origin of Chemical Diversity in Prochloron-Tunicate Symbiosis
Lin, Z., Torres, J. P., Tianero, M. D. B., Kwan, J. C., & Schmidt, E. W. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.00860-16 · Cited by 27
Self-citationSingle-cell metabolite detection and genomics reveals uncultivated talented producer
Kogawa, M., Miyaoka, R., Hemmerling, F., Ando, M., Yura, K., Ide, K., Nishikawa, Y., Hosokawa, M., Ise, Y., Cahn, J. K. B., et al. (2022) · PNAS Nexus · doi:10.1093/pnasnexus/pgab007 · Cited by 27
Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria
D’Agostino, P. M. (2023) · Natural Product Reports · doi:10.1039/d3np00011g · Cited by 26
Erwin, P. M., Pineda, M.-C., Webster, N. S., Turón, X., & López‐Legentil, S. (2012) · Symbiosis · doi:10.1007/s13199-012-0204-0 · Cited by 27
Mechanisms and Evolution of Diversity-Generating RiPP Biosynthesis
Le, T., & van der Donk, W. A. (2021) · Trends in Chemistry · doi:10.1016/j.trechm.2021.01.003 · Cited by 24
Nguyen, N. A., Cong, Y., Hurrell, R. C., Arias, N., Garg, N., Puri, A. W., Schmidt, E. W., & Agarwal, V. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00251 · Cited by 26
Self-citationRobbel, L., Hoyer, K. M., & Marahiel, M. A. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.06897.x · Cited by 26
Kwan, J. C., Tianero, M. D. B., Donia, M. S., Wyche, T. P., Bugni, T. S., & Schmidt, E. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095850 · Cited by 25
Self-citationJones, A. C., Gerwick, L. G., Gonzalez, D. J., Dorrestein, P. C., & Gerwick, W. H. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-247 · Cited by 25
Cantrell, T. P., Freeman, C. J., Paul, V. J., Agarwal, V., & Garg, N. (2019) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-019-02207-5 · Cited by 25
Cellular Origin of Dysiherbaine, an Excitatory Amino Acid Derived from a Marine Sponge
Sakai, R., Yoshida, K., Kimura, A. K., Koike, K., Jimbo, M., Koike, K., Kobiyama, A., & Kamiya, H. (2008) · ChemBioChem · doi:10.1002/cbic.200700498 · Cited by 25
The astaxanthin dideoxyglycoside biosynthesis pathway in Sphingomonas sp. PB304
Kim, S. H., Kim, J., Lee, B. Y., & Lee, P. C. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-014-6050-7 · Cited by 25
The natural product biosynthetic potential of Red Sea nudibranch microbiomes
Abdelrahman, S. M., Patin, N., Hanora, A., Aboseidah, A., Desoky, S., Desoky, S. G., Stewart, F. J., & Lopanik, N. B. (2021) · PeerJ · doi:10.7717/peerj.10525 · Cited by 23
An Overview of Bioactive 1,3-Oxazole-Containing Alkaloids from Marine Organisms
Chen, J., Lv, S.-Y., Liu, J., Yu, Y., Wang, H., & Zhang, H. (2021) · Pharmaceuticals · doi:10.3390/ph14121274 · Cited by 24
Sikandar, A., & Koehnke, J. (2019) · Natural Product Reports · doi:10.1039/c8np00064f · Cited by 23
Hernández‐Prieto, M. A., Semeniuk, T. A., & Futschik, M. E. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00191 · Cited by 23
Derivatisable Cyanobactin Analogues: A Semisynthetic Approach
Oueis, E., Adamson, C. S., Mann, G., Ludewig, H., Redpath, P., Migaud, M. E., Westwood, N. J., & Naismith, J. H. (2015) · ChemBioChem · doi:10.1002/cbic.201500494 · Cited by 23
Antimicrobial Peptides Produced by Microorganisms
Paiva, A. D., & Breukink, E. J. (2012) · Springer eBooks · doi:10.1007/978-3-0348-0541-4_3 · Cited by 23
Cycloforskamide, a Cytotoxic Macrocyclic Peptide from the Sea Slug Pleurobranchus forskalii
Tan, K. C., Wakimoto, T., Takada, K., Ohtsuki, T., Uchiyama, N., Goda, Y., & Abe, I. (2013) · Journal of Natural Products · doi:10.1021/np400404r · Cited by 23
Hamann, M. T. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207780162818 · Cited by 23
Microbial diversity associated with ascidians: a review of research methods and application
Chen, L., Fu, C.-M., & Wang, G. (2016) · Symbiosis · doi:10.1007/s13199-016-0398-7 · Cited by 23
Bhushan, A., Peters, E. E., & Piel, J. (2017) · Progress in molecular and subcellular biology · doi:10.1007/978-3-319-51284-6_9 · Cited by 23
Three Principles of Diversity-Generating Biosynthesis
Gu, W., & Schmidt, E. W. (2017) · Accounts of Chemical Research · doi:10.1021/acs.accounts.7b00330 · Cited by 22
Self-citationTaxonomic and Metabolite Diversity of Actinomycetes Associated with Three Australian Ascidians
Buedenbender, L., Carroll, A. R., Ekins, M., & Kurtböke, D. İ. (2017) · Diversity · doi:10.3390/d9040053 · Cited by 22
The Chemistry of Marine Algae and Cyanobacteria
Choi, H., Pereira, A. R., & Gerwick, W. H. (2012) · Springer eBooks · doi:10.1007/978-90-481-3834-0_2 · Cited by 22
The origins of cyanobactin chemistry and biology
Jaspars, M. (2014) · Chemical Communications · doi:10.1039/c3cc49252d · Cited by 26
Nature's bounty – drug discovery from the sea
Bowling, J. J., Kochanowska-Karamyan, A. J., Kasanah, N., & Hamann, M. T. (2007) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2.11.1505 · Cited by 21
Biodegradation of synthetic organic pollutants: principles, progress, problems, and perspectives
Huang, Y. L., Deng, Y., Yu, K., Li, B. J., & Zhang, T. (2025) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuaf043 · Cited by 23
The Biosynthesis of Heterophyllin B in Pseudostellaria heterophylla From prePhHB-Encoded Precursor
Zheng, W., Zhou, T., Li, J., Jiang, W., Zhang, J., Xiao, C., Wei, D., Yang, C., Xu, R., Gong, A., et al. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2019.01259 · Cited by 21
Sukmarini, L. (2022) · Marine Drugs · doi:10.3390/md20090544 · Cited by 21
Genome Mining: Concept and Strategies for Natural Product Discovery
Nett, M. (2014) · Fortschritte der Chemie Organischer Naturstoffe/Fortschritte der Chemie organischer Naturstoffe/Progress in the chemistry of organic natural products · doi:10.1007/978-3-319-04900-7_4 · Cited by 21
Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations
Miller, I., Chevrette, M., & Kwan, J. (2017) · Marine Drugs · doi:10.3390/md15060165 · Cited by 21
Biosynthetic Proteases That Catalyze the Macrocyclization of Ribosomally Synthesized Linear Peptides
Ongpipattanakul, C., & Nair, S. K. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00114 · Cited by 20
Dror, H., Novak, L., Evans, J. S., López‐Legentil, S., & Shenkar, N. (2018) · Microbial Ecology · doi:10.1007/s00248-018-1276-z · Cited by 21
Koplovitz, G., McClintock, J. B., Amsler, C. D., & Baker, B. J. (2011) · Marine Biology · doi:10.1007/s00227-011-1764-x · Cited by 20
Choi, H., & Oh, D. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0639-y · Cited by 20
Symbiotic Associations in Ascidians: Relevance for Functional Innovation and Bioactive Potential
Matos, A., & Antunes, A. (2021) · Marine Drugs · doi:10.3390/md19070370 · Cited by 20
Beyond Soil-Dwelling Actinobacteria: Fantastic Antibiotics and Where to Find Them
Santos‐Aberturas, J., & Vior, N. M. (2022) · Antibiotics · doi:10.3390/antibiotics11020195 · Cited by 23
Zur Biosynthese von Thiopeptidantibiotika
Arndt, H., Schoof, S., & Lu, J. (2009) · Angewandte Chemie · doi:10.1002/ange.200901808 · Cited by 19
Insights into the Mechanism of the Cyanobactin Heterocyclase Enzyme
Ge, Y., Czekster, C. M., Miller, O. K., Botting, C. H., Schwarz‐Linek, U., & Naismith, J. H. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00084 · Cited by 19
Tang, K. C., & Raj, M. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202007608 · Cited by 19
Rynearson, T. A., & Palenik, B. P. (2011) · Advances in marine biology · doi:10.1016/b978-0-12-385529-9.00001-9 · Cited by 19
Localization of granulatimide alkaloids in the tissues of the ascidian Didemnum granulatum
Seleghim, M. H. R., de Lira, S. P., Campana, P. T., Berlinck, R. G. S., & Custódio, M. R. (2006) · Marine Biology · doi:10.1007/s00227-006-0410-5 · Cited by 19
Zhao, S., Feng, R., Gu, Y., Han, L., Cong, X., Liu, Y., Liu, S., Shen, Q., Huo, L., & Yan, F. (2023) · Engineering Microbiology · doi:10.1016/j.engmic.2023.100137 · Cited by 18
Murray, A. E., Lo, C., Daligault, H. E., Avalon, N. E., Read, R. W., Davenport, K. W., Higham, M. L., Kunde, Y. A., Dichosa, A. E. K., Baker, B. J., et al. (2021) · mSphere · doi:10.1128/msphere.00759-21 · Cited by 18
Negri, T., Mantri, S. S., Angelov, A., Peter, S., Muth, G., Eustáquio, A. S., & Ziemert, N. (2022) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-022-11917-y · Cited by 18
Insights into the Electronic Structure of CuIIBound to an Imidazole Analogue of Westiellamide
Comba, P., Dovalil, N., Hanson, G. R., Harmer, J. R., Noble, C. J., Riley, M. J., & Seibold, B. (2014) · Inorganic Chemistry · doi:10.1021/ic5014413 · Cited by 18
Mann, G., Koehnke, J., Bent, A. F., Graham, R. S., Houssen, W. E., Jaspars, M., Schwarz‐Linek, U., & Naismith, J. H. (2014) · Acta Crystallographica Section F Structural Biology Communications · doi:10.1107/s2053230x1402425x · Cited by 18
Dinuclear Zn II and mixed Cu II –Zn II complexes of artificial patellamides as phosphatase models
Comba, P., Eisenschmidt, A., Gahan, L. R., Hanson, G. R., Mehrkens, N., & Westphal, M. (2016) · Dalton Transactions · doi:10.1039/c6dt03787a · Cited by 18
Antiproliferative Bistramides from Trididemnum cyclops from Madagascar
Murphy, B. T., Cao, S., Brodie, P. J., Maharavo, J., Andriamanantoanina, H., Ravelonandro, P., & Kingston, D. G. I. (2009) · Journal of Natural Products · doi:10.1021/np900072k · Cited by 18
Biocatalysis in pharmaceutical preparation and alteration
Wilkinson, B. M., & Bachmann, B. O. (2006) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2006.02.006 · Cited by 18
Taton, A., Rohrer, S., Diaz, B., Reher, R., Caraballo‐Rodríguez, A. M., Pierce, M. L., Dorrestein, P. C., Gerwick, L. G., Gerwick, W. H., & Golden, J. W. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00347 · Cited by 17
Martins, J., Leão, P. N., Ramos, V., & Vasconcelos, V. M. (2013) · Marine Drugs · doi:10.3390/md11124902 · Cited by 17
Xu, W., Li, L., Du, L., & Tan, N. (2011) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmr062 · Cited by 17
Eighteen New Aeruginosamide Variants Produced by the Baltic Cyanobacterium Limnoraphis CCNP1324
Cegłowska, M., Szubert, K., Wieczerzak, E., Kosakowska, A., & Mazur‐Marzec, H. (2020) · Marine Drugs · doi:10.3390/md18090446 · Cited by 17
Fungi from Different Environments
(2009) · Science Publishers eBooks · doi:10.1201/b10191 · Cited by 17
In Vitro Biosynthesis of Peptides Containing Exotic Azoline Analogues
Goto, Y., & Suga, H. (2019) · ChemBioChem · doi:10.1002/cbic.201900521 · Cited by 17
Trikoramides B–D, Bioactive Cyanobactins from the Marine Cyanobacterium Symploca hydnoides
Phyo, M. Y., Goh, T. M. B., Goh, J. X., & Tan, L. T. (2021) · Marine Drugs · doi:10.3390/md19100548 · Cited by 16
Promiscuous Enzymes for Residue‐Specific Peptide and Protein Late‐Stage Functionalization
Alexander, A. K., & Elshahawi, S. I. (2023) · ChemBioChem · doi:10.1002/cbic.202300372 · Cited by 16
Emerging pharmaceutical therapies of Ascidian-derived natural products and derivatives
Cooreman, K., Spiegeleer, B. M. J. D., Poucke, C. V., Vanavermaete, D., Delbare, D., Wynendaele, E., & Witte, B. D. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104254 · Cited by 16
Taxonomy and Marine Natural Products Research
Blunt, J. W., Buckingham, J., & Munro, M. H. G. (2012) · Springer eBooks · doi:10.1007/978-90-481-3834-0_1 · Cited by 16
Drug Discovery and Development via Synthetic Biology
Cobb, R. E., Luo, Y., Freestone, T. S., & Zhao, H. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-394430-6.00010-8 · Cited by 16
Impact of metagenomics on biotechnological development
Шестаков, С. В. (2012) · Applied Biochemistry and Microbiology · doi:10.1134/s0003683812090050 · Cited by 16
An Analysis of Biosynthesis Gene Clusters and Bioactivity of Marine Bacterial Symbionts
Viju, N., Punitha, S. M. J., & Satheesh, S. (2021) · Current Microbiology · doi:10.1007/s00284-021-02535-4 · Cited by 16
Possible Functional Roles of Patellamides in the Ascidian-Prochloron Symbiosis
Baur, P., Kühl, M., Comba, P., & Behrendt, L. (2022) · Marine Drugs · doi:10.3390/md20020119 · Cited by 17
Using genomics to deliver natural products from symbiotic bacteria.
Clardy, J. (2005) · Genome biology · doi:10.1186/gb-2005-6-9-232 · Cited by 16
Gao, S., Ge, Y., Bent, A. F., Schwarz‐Linek, U., & Naismith, J. H. (2018) · Biochemistry · doi:10.1021/acs.biochem.8b00835 · Cited by 15
Cyanobacterial interactions and symbiosis
Manoharan, D., Ramachandran, T., Sivakumar, N., & Rajaram, S. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13231-5.00004-0 · Cited by 16
Linthorne, J. S., Chang, B. J., Flematti, G. R., Ghisalberti, E. L., & Sutton, D. C. (2014) · Marine Biotechnology · doi:10.1007/s10126-014-9592-x · Cited by 15
Baur, P., Comba, P., & Velmurugan, G. (2022) · Chemistry - A European Journal · doi:10.1002/chem.202200249 · Cited by 15
Secondary Metabolites of Cyanobacteria and Drug Development
Mandal, S., & Rath, J. (2014) · SpringerBriefs in pharmaceutical science & drug development · doi:10.1007/978-3-319-12009-6_2 · Cited by 15
Chen, B., & Heal, W. P. (2008) · Elsevier eBooks · doi:10.1016/b978-008044992-0.00406-5 · Cited by 15
López‐Legentil, S., Turón, X., & Erwin, P. M. (2016) · Frontiers in Zoology · doi:10.1186/s12983-016-0134-4 · Cited by 14
Crnkovic, C. M., Braesel, J., Krunić, A., Eustáquio, A. S., & Orjala, J. (2019) · ChemBioChem · doi:10.1002/cbic.201900511 · Cited by 14
Applying Promiscuous RiPP Enzymes to Peptide Backbone N ‑Methylation Chemistry
Sarkar, S., Gu, W., & Schmidt, E. W. (2022) · ACS Chemical Biology · doi:10.1021/acschembio.2c00293 · Cited by 14
Self-citationXie, S., Savchenko, A. I., Kerscher, M., Grange, R. L., Krenske, E. H., Harmer, J. R., Bauer, M. J., Broit, N., Watters, D. J., Boyle, G. M., et al. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201701659 · Cited by 13
Chen, L., Wang, X., Fu, C.-M., & Wang, G. (2019) · BioMed Research International · doi:10.1155/2019/7851251 · Cited by 14
Combinatorial biosynthesis in symbiotic bacteria
Piel, J. (2006) · Nature Chemical Biology · doi:10.1038/nchembio1206-661 · Cited by 14
Metagenomics-Guided Mining of Commercially Useful Biocatalysts from Marine Microorganisms
Uria, A. R., & Zilda, D. S. (2016) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2016.05.001 · Cited by 13
Sabat, S., Patra, S., Swain, S. N., Bej, S., Bishoyi, A. K., Sahoo, C. R., & Padhy, R. N. (2025) · ACS Omega · doi:10.1021/acsomega.5c03526 · Cited by 15
Sardar, D., Tianero, M. D. B., & Schmidt, E. W. (2016) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/bs.mie.2016.02.012 · Cited by 13
Self-citationKato, Y., Kuroda, T., Huang, Y., Ohta, R., Goto, Y., & Suga, H. (2019) · Angewandte Chemie International Edition · doi:10.1002/anie.201910894 · Cited by 13
Diverse Aromatic Metabolites in the Solitary Tunicate Cnemidocarpa irene
Miyako, K., Yasuno, Y., Shinada, T., Fujita, M., & Sakai, R. (2020) · Journal of Natural Products · doi:10.1021/acs.jnatprod.0c00789 · Cited by 13
In Situ Natural Product Discovery via an Artificial Marine Sponge
Clair, J. J. L., Loveridge, S. T., Tenney, K., O’Neil-Johnson, M., Chapman, E., & Crews, P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100474 · Cited by 13
Goto, Y., & Suga, H. (2016) · Chemistry Letters · doi:10.1246/cl.160562 · Cited by 13
Metadata
- Authors
- Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J.
- Affiliations
- Scripps Institution of Oceanography (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2005-05-09
- Volume
- 102
- Issue
- 20
- Pages
- 7315-7320
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC1091749
- OpenAlex
- W2162481919
- Cited by
- 567
- References
- 53
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 14 · 2023: 12 · 2022: 27 · 2021: 22 · 2020: 22 · 2019: 28 · 2018: 26 · 2017: 33 · 2016: 26 · 2015: 27 · 2014: 38 · 2013: 32 · 2012: 41
- FWCI
- 18.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- other-oa
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion, other-oa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Science Foundation (0412226)
- Topics
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Physical Sciences › Chemistry › Organic Chemistry › Isoquinoline Alkaloid Synthesis
- Keywords
- cyanobacterial symbionts, Lissoclinum patella, heterocyclization, biosynthetic gene clusters, Trichodesmium erythraeum, marine natural products, heterologous expression
- MeSH terms
- Cyanobacteria, Amino Acid Sequence, Animals, Bacteriocins, Chromatography, High Pressure Liquid, Escherichia coli, Molecular Sequence Data, Peptides, Cyclic, Symbiosis, Urochordata, Open Reading Frames, Sequence Analysis, DNA, DNA Primers, Palau, Prochloron
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review