Marine natural products as anticancer drugs

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Natural products as sources of new drugs over the period 1981–2002

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Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials

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The isolation and structure of a remarkable marine animal antineoplastic constituent: dolastatin 10

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Ecteinascidins 729, 743, 745, 759A, 759B, and 770: potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata

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In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B.

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Palytoxin: A New Marine Toxin from a Coelenterate

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Natural products ? a simple model to explain chemical diversity

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Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data

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Isolation of Dolastatin 10 from the Marine Cyanobacterium <i>Symploca</i> Species VP642 and Total Stereochemistry and Biological Evaluation of Its Analogue Symplostatin 1

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Why Are Secondary Metabolites (Natural Products) Biosynthesized?

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Dolastatin 10, a powerful cytostatic peptide derived from a marine animal

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Psammaplins from the Sponge Pseudoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase

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Norhalichondrin A: an antitumor polyether macrolide from a marine sponge

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Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

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Antitumor tetrahydroisoquinoline alkaloids from the colonial ascidian Ecteinascidia turbinata

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Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate

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Ecteinascidin 743: A Minor Groove Alkylator That Bends DNA toward the Major Groove

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Drugs from the Sea

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Cyanobacterial symbiont biosynthesis of chlorinated metabolites fromDysidea herbacea (Porifera)

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Barbamide, a Chlorinated Metabolite with Molluscicidal Activity from the Caribbean Cyanobacterium Lyngbya majuscula

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Nitrogen-containing metabolites from marine cyanobacteria

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New Marine Derived Anticancer Therapeutics ─ A Journey from the Sea to Clinical Trials

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Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery

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Natural products as probes of cell biology: 20 years of didemnin research

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Isolation and structure of the cytostatic linear depsipeptide dolastatin 15

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Structure−Activity Relationships of the Didemnins

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Progress in the development and acquisition of anticancer agents from marine sources

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Phenolic constituents of

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Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4

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Symplostatin 2: A Dolastatin 13 Analogue from the Marine Cyanobacterium Symploca hydnoides

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Antiproliferative effect of dehydrodidemnin B (DDB), a depsipeptide isolated from Mediterranean tunicates

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GTP-dependent binding of the antiproliferative agent didemnin to elongation factor 1 alpha.

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A phase III study of radiation therapy plus carmustine with or without recombinant interferon-? in the treatment of patients with newly diagnosed high-grade glioma

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Phase II study of dolastatin-10 in patients with hormone-refractory metastatic prostate adenocarcinoma.

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Symplostatin 1: A Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca hydnoides

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Brominated tyrosine metabolites from an unidentified sponge

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Synthesis and Antitumor Activity of Novel Dolastatin 10 Analogs.

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Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller)

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Approaches to identify, clone, and express symbiont bioactive metabolite genes

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Antitumor Activity of TZT‐1027, a Novel Doiastatin 10 Derivative

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Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors.

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The Discovery of NVP-LAQ824: From Concept to Clinic

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Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin

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Psammaplin A, a marine natural product, inhibits aminopeptidase N and suppresses angiogenesis in vitro

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Symbiotic Bacteria in Sponges: Sources of Bioactive Substances

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Biochemical and cellular effects of didemnins A and B.

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Synthetic studies on the marine natural product halichondrins

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Pharmaceutical development of anticancer agents derived from marine sources

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A phase II trial of dolastatin-10 in recurrent platinum-sensitive ovarian carcinoma: a Gynecologic Oncology Group study

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Two bromotyrosine-cysteine derived metabolites from a sponge

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Genetic Evidence Supports Secondary Metabolic Diversity in Prochloron spp., the Cyanobacterial Symbiont of a Tropical Ascidian

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Psammaplin A, a natural phenolic compound, has inhibitory effect on human topoisomerase II and is cytotoxic to cancer cells.

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LU103793 (NSC D-669356): a synthetic peptide that interacts with microtubules and inhibits mitosis.

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Compounds produced from potential tunicate-blue-green algal symbiosis: A review

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Localization Studies of Bioactive Cyclic Peptides in the Ascidian Lissoclinum patella

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Venom of the lionfish Pterois volitans

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Phase II study of LU 103793 (dolastatin analogue) in patients with metastatic breast cancer

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Total synthesis of halichondrins: Enantioselective construction of a homochiral pentacyclic C1-C15 intermediate from d-ribose

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Effect of Aplidin in acute lymphoblastic leukaemia cells

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Antitumor activity of TZT‐1027 (Soblidotin) against vascular endothelial growth factor‐secreting human lung cancer in vivo

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Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel–Dreyer chromatography

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Peptides isolated from the venom of Conus geographus block neuromuscular transmission

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A Phase II Study of the Dolastatin 15 Analogue LU 103793 in the Treatment of Advanced Non–Small-Cell Lung Cancer

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Activity of the dolastatin analogue, LU103793, in malignant melanoma

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Phase I and pharmacokinetic study of the water-soluble dolastatin 15 analog LU103793 in patients with advanced solid malignancies.

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Rapamycin inhibits didemnin B‐induced apoptosis in human HL‐60 cells: Evidence for the possible involvement of FK506‐binding protein 25

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Phase II study of synthadotin (SYN-D; ILX651) administered daily for 5 consecutive days once every 3 weeks (qdx5q3w) in patients (Pts) with inoperable locally advanced or metastatic melanoma

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National Cooperative Drug Discovery Groups (NCDDGs): A Successful Model for Public Private Partnerships in Cancer Drug Discovery

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A phase II study of trabectedin (ET-743) as a second line therapy in patients with persistent or recurrent endometrial carcinoma

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A phase II study of weekly trabectedin (ET-743) in second/third line ovarian carcinoma

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Sponge-Associated Microorganisms: Evolution, Ecology, and Biotechnological Potential

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Natural compounds for cancer treatment and prevention

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Natural products as leads to anticancer drugs

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Patellamide A and C biosynthesis by a microcin-like pathway in <i>Prochloron didemni</i> , the cyanobacterial symbiont of <i>Lissoclinum patella</i>

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Marine Natural Products: A Source of Novel Anticancer Drugs

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Engineering cyanobacteria to generate high-value products

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Anticancer Activity of Natural Compounds from Plant and Marine Environment

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Small Bioactive Peptides for Biomaterials Design and Therapeutics

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Marine natural products

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Marine Natural Products: A New Wave of Drugs?

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