The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention
Open accessAbstract
The peroxisome proliferator-activated receptor subtype γ (PPARγ) ligands, namely the synthetic insulin-sensitizing thiazolidinedione (TZD) compounds, have demonstrated great potential in the treatment of type II diabetes. However, their clinical applicability is limited by a common and serious side effect of edema. To address the mechanism of TZD-induced edema, we generated mice with collecting duct (CD)-specific disruption of the PPARγ gene. We found that mice with CD knockout of this receptor were resistant to the rosiglitazone- (RGZ) induced increases in body weight and plasma volume expansion found in control mice expressing PPARγ in the CD. RGZ reduced urinary sodium excretion in control and not in conditional knockout mice. Furthermore, RGZ stimulated sodium transport in primary cultures of CD cells expressing PPARγ and not in cells lacking this receptor. These findings demonstrate a PPARγ-dependent pathway in regulation of sodium transport in the CD that underlies TZD-induced fluid retention.
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Cited by
PPARγ signaling and metabolism: the good, the bad and the future
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PPARγ and the global map of adipogenesis and beyond
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Metadata
- Authors
- Zhang, H., Zhang, A., Kohan, D. E., Nelson, R. D., Gonzalez, F. J., & Yang, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-06-14
- Volume
- 102
- Issue
- 26
- Pages
- 9406-9411
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060060473
- Cited by
- 317
- References
- 41
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Zhang, H., Zhang, A., Kohan, D. E., Nelson, R. D., Gonzalez, F. J., & Yang, T. (2005). Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0501744102
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