PPARγ signaling and metabolism: the good, the bad and the future

Brown Adipose Tissue: Function and Physiological Significance

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

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An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor γ (PPARγ)

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Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor

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A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

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15-Deoxy-Δ12,14-Prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

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Macrophage-specific PPARγ controls alternative activation and improves insulin resistance

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Fat and Beyond: The Diverse Biology of PPARγ

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PPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development

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Oxidized LDL Regulates Macrophage Gene Expression through Ligand Activation of PPARγ

Nagy, L., Tontonoz, P., Alvarez, J. G. A., Chen, H.-W., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81574-3 · Cited by 1,861 · see citing works

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomázy, V. A., & Evans, R. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81575-5 · Cited by 1,800 · see citing works

PPARs and the complex journey to obesity

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Chronic Peroxisome Proliferator-activated Receptor γ (PPARγ) Activation of Epididymally Derived White Adipocyte Cultures Reveals a Population of Thermogenically Competent, UCP1-containing Adipocytes Molecularly Distinct from Classic Brown Adipocytes

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A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ

Pascual, G., Fong, A. L., Ogawa, S., Gamliel, A., Li, A. C., Perissi, V., Rose, D. W., Willson, T. M., Rosenfeld, M. G., & Glass, C. K. (2005) · Nature · doi:10.1038/nature03988 · Cited by 1,251 · see citing works

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

Cipolletta, D., Feuerer, M., Li, A., Kamei, N., Lee, J., Shoelson, S. E., Benoist, C., & Mathis, D. (2012) · Nature · doi:10.1038/nature11132 · Cited by 1,143 · see citing works

White Fat Progenitor Cells Reside in the Adipose Vasculature

Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D., & Graff, J. M. (2008) · Science · doi:10.1126/science.1156232 · Cited by 1,113 · see citing works

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

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PPAR-γ dependent and independent effects on macrophage-gene expression in lipid metabolism and inflammation

Chawla, A., Barak, Y., Nagy, L., Liao, D., Tontonoz, P., & Evans, R. M. (2001) · Nature Medicine · doi:10.1038/83336 · Cited by 1,069 · see citing works

A decade of CDK5

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Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγ

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Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

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Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

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PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Akune, T., Ohba, S., Kamekura, S., Yamaguchi, M., Chung, U., Kubota, N., Terauchi, Y., Harada, Y., Azuma, Y., Nakamura, K., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci19900 · Cited by 871 · see citing works

PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scalePreprint

Lefterova, M. I., Zhang, Y., Steger, D. J., Schupp, M., Schug, J., Cristancho, A. G., Feng, D., Zhuo, D. X., Stoeckert, C. J., Liu, X. S., et al. (2008) · Genes & Development · doi:10.1101/gad.1709008 · Cited by 826 · see citing works

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

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Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

Qiang, L., Wang, L., Kon, N., Zhao, W., Lee, S., Zhang, Y., ROSENBAUM, M. S., Zhao, Y., Gu, W. J., Farmer, S. R., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.027 · Cited by 802 · see citing works

A Comparison of Lipid and Glycemic Effects of Pioglitazone and Rosiglitazone in Patients With Type 2 Diabetes and Dyslipidemia

Goldberg, R. B., Kendall, D. M., Deeg, M. A., Buse, J. B., Zagar, A. J., Pinaire, J. A., Tan, M. H., Khan, M. A., Perez, A. T., Jacober, S. J., et al. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1547 · Cited by 790 · see citing works

Autophagy in the Cellular Energetic Balance

Singh, R., & Cuervo, A. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.04.004 · Cited by 788 · see citing works

Liver Peroxisome Proliferator-activated Receptor γ Contributes to Hepatic Steatosis, Triglyceride Clearance, and Regulation of Body Fat Mass

Gavrilova, O., Haluzı́k, M., Matsusue, K., Cutson, J. J., Johnson, L. K., Dietz, K. R., Nicol, C. J. B., Vinson, C., Gonzalez, F. J., & Reitman, M. L. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300043200 · Cited by 759 · see citing works

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

Ohno, H., Shinoda, K., Spiegelman, B. M., & Kajimura, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.019 · Cited by 749 · see citing works

Induction of Adiponectin, a Fat-Derived Antidiabetic and Antiatherogenic Factor, by Nuclear Receptors

Iwaki, M., Matsuda, M., Maeda, N., Funahashi, T., Matsuzawa, Y., Makishima, M., & Shimomura, I. (2003) · Diabetes · doi:10.2337/diabetes.52.7.1655 · Cited by 740 · see citing works

PPAR γ insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors

Akune, T., Ohba, S., Kamekura, S., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419900 · Cited by 730 · see citing works

The Effect of Thiazolidinediones on Plasma Adiponectin Levels in Normal, Obese, and Type 2 Diabetic Subjects

Yu, J. G., Javorschi, S., Hevener, A. L., Kruszynska, Y. T., Norman, R. A., Sinha, M. K., & Olefsky, J. M. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2968 · Cited by 724 · see citing works

AMPK: a key regulator of energy balance in the single cell and the whole organism

Hardie, D. G. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.116 · Cited by 705 · see citing works

PPARs at the crossroads of lipid signaling and inflammation

Wahli, W., & Michalik, L. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.05.001 · Cited by 677 · see citing works

Impact of current treatments on liver disease, glucose metabolism and cardiovascular risk in non-alcoholic fatty liver disease (NAFLD): a systematic review and meta-analysis of randomised trials

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The Effects of Rosiglitazone on Insulin Sensitivity, Lipolysis, and Hepatic and Skeletal Muscle Triglyceride Content in Patients With Type 2 Diabetes

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PPAR : a dagger in the heart of the metabolic syndrome

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Thiazolidinediones expand body fluid volume through PPARγ stimulation of ENaC-mediated renal salt absorption

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Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists

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Next-generation genomics: an integrative approach

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Obesity Associated with a Mutation in a Genetic Regulator of Adipocyte Differentiation

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Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

Choi, J. H., Banks, A. S., Kamenecka, T. M., Busby, S. A., Chalmers, M. J., Kumar, N., Kuruvilla, D. S., Shin, Y., He, Y., Bruning, J. B., et al. (2011) · Nature · doi:10.1038/nature10383 · Cited by 541 · see citing works

Fibroblast Growth Factor-21 Regulates PPARγ Activity and the Antidiabetic Actions of Thiazolidinediones

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PPAR-γ regulates osteoclastogenesis in mice

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Risk of Acute Myocardial Infarction, Stroke, Heart Failure, and Death in Elderly Medicare Patients Treated With Rosiglitazone or Pioglitazone

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PPARs: Fatty acid sensors controlling metabolism

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Muscle-specific Pparg deletion causes insulin resistance

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Differential activation of adipogenesis by multiple PPAR isoforms.Preprint

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Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

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STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells

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Regulation of Peroxisome Proliferator-activated Receptor γ Activity by Mitogen-activated Protein Kinase

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PPAR gamma 2 Prevents Lipotoxicity by Controlling Adipose Tissue Expandability and Peripheral Lipid Metabolism

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Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ

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The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

Nedergaard, J., & Cannon, B. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.03.007 · Cited by 426 · see citing works

Human Metabolic Syndrome Resulting From Dominant-Negative Mutations in the Nuclear Receptor Peroxisome Proliferator-Activated Receptor-γ

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Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones

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Thiazolidinediones and PPARγ agonists: time for a reassessment

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Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance

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Peroxisome proliferator-activated receptor γ is required in mature white and brown adipocytes for their survival in the mouse

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Degradation of the Peroxisome Proliferator-activated Receptor γ Is Linked to Ligand-dependent Activation

Hauser, S., Adelmant, G., Sarraf, P., Wright, H. M., Mueller, E., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001297200 · Cited by 367 · see citing works

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

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Comprehensive Messenger Ribonucleic Acid Profiling Reveals That Peroxisome Proliferator-Activated Receptor γ Activation Has Coordinate Effects on Gene Expression in Multiple Insulin-Sensitive Tissues

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Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice

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Troglitazone action is independent of adipose tissue.

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Targeted estrogen delivery reverses the metabolic syndrome

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Compensation by Fibroblast Growth Factor 1 (FGF1) Does Not Account for the Mild Phenotypic Defects Observed in FGF2 Null Mice

Miller, D. L., Ortega, S., Bashayan, O., Basch, R. S., & Basilico, C. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.6.2260-2268.2000 · Cited by 326 · see citing works

Collecting duct-specific deletion of peroxisome proliferator-activated receptor γ blocks thiazolidinedione-induced fluid retention

Zhang, H., Zhang, A., Kohan, D. E., Nelson, R. D., Gonzalez, F. J., & Yang, T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501744102 · Cited by 316 · see citing works

Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone.

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A PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis

Jonker, J., Suh, J. M., Atkins, A., Ahmadian, M., Li, P., Whyte, J., He, M., Juguilon, H., Yin, Y.-Q., Phillips, C. T., et al. (2012) · Nature · doi:10.1038/nature10998 · Cited by 286 · see citing works

Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study

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Selective estrogen receptor modulators (SERMs): Mechanisms of anticarcinogenesis and drug resistance

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Insulin- and Mitogen-activated Protein Kinase-mediated Phosphorylation and Activation of Peroxisome Proliferator-activated Receptor γ

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A Novel Heterozygous Mutation in Peroxisome Proliferator-Activated Receptor-γ Gene in a Patient with Familial Partial Lipodystrophy

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The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study

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PPARG F388L, a Transactivation-Deficient Mutant, in Familial Partial Lipodystrophy

Hegele, R. A., Cao, H., Frankowski, C., Mathews, S. T., & Leff, T. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3586 · Cited by 263 · see citing works

PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

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Cardiomyocyte-Specific Knockout and Agonist of Peroxisome Proliferator–Activated Receptor-γ Both Induce Cardiac Hypertrophy in Mice

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Functional Antagonism between CCAAT/Enhancer Binding Protein-α and Peroxisome Proliferator-activated Receptor-γ on the Leptin Promoter

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