The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection
Open accessAbstract
Staphylococcus saprophyticus is a uropathogenic Staphylococcus frequently isolated from young female outpatients presenting with uncomplicated urinary tract infections. We sequenced the whole genome of S. saprophyticus type strain ATCC 15305, which harbors a circular chromosome of 2,516,575 bp with 2,446 ORFs and two plasmids. Comparative genomic analyses with the strains of two other species, Staphylococcus aureus and Staphylococcus epidermidis , as well as experimental data, revealed the following characteristics of the S. saprophyticus genome. S. saprophyticus does not possess any virulence factors found in S. aureus , such as coagulase, enterotoxins, exoenzymes, and extracellular matrix-binding proteins, although it does have a remarkable paralog expansion of transport systems related to highly variable ion contents in the urinary environment. A further unique feature is that only a single ORF is predictable as a cell wall-anchored protein, and it shows positive hemagglutination and adherence to human bladder cell associated with initial colonization in the urinary tract. It also shows significantly high urease activity in S. saprophyticus . The uropathogenicity of S. saprophyticus can be attributed to its genome that is needed for its survival in the human urinary tract by means of novel cell wall-anchored adhesin and redundant uro-adaptive transport systems, together with urease.
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Cites
Staphylococcus aureus Sortase, an Enzyme that Anchors Surface Proteins to the Cell Wall
Mazmanian, S. K., Liu, G., Ton-That, H., & Schneewind, O. (1999) · Science · doi:10.1126/science.285.5428.760 · Cited by 1,053
Jones, B. D., Lockatell, C. V., Johnson, D. E., Warren, J. W., & Mobley, H. L. (1990) · Infection and Immunity · doi:10.1128/iai.58.4.1120-1123.1990 · Cited by 178
Cited by
Multiplex-PCR Method for Species Identification of Coagulase-Positive Staphylococci
Sasaki, T., Tsubakishita, S., Tanaka, Y., Sakusabe, A., Ohtsuka, M., Hirotaki, S., Kawakami, T., Fukata, T., & Hiramatsu, K. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01232-09 · Cited by 438
Coagulase-Negative Staphylococcal Infections
Rogers, K. L., Fey, P. D., & Rupp, M. E. (2009) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2008.10.001 · Cited by 401
Phage-mediated horizontal gene transfer and its implications for the human gut microbiome
Borodovich, T., Shkoporov, A. N., Ross, R. P., & Hill, C. (2022) · Gastroenterology Report · doi:10.1093/gastro/goac012 · Cited by 200
Hiron, A., Posteraro, B., Carrière, M., Remy, L., Delporte, C., La Sorda, M., Sanguinetti, M., Juillard, V., & Borezée-Durant, E. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07287.x · Cited by 97
Metadata
- Authors
- Kuroda, M., Yamashita, A., Hirakawa, H., Kumano, M., Morikawa, K., Higashide, M., Maruyama, A., Inose, Y., Matoba, K., Toh, H., Kuhara, S., Hattori, M., & Ohta, T.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-31
- Volume
- 102
- Issue
- 37
- Pages
- 13272-13277
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2097186016
- Cited by
- 243
- References
- 2
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection. https://app.cochat.ai/papers/10.1073/pnas.0502950102
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- Kuroda, M., Yamashita, A., Hirakawa, H., Kumano, M., Morikawa, K., Higashide, M., Maruyama, A., Inose, Y., Matoba, K., Toh, H., Kuhara, S., Hattori, M., & Ohta, T. (2005). Whole genome sequence of Staphylococcus saprophyticus reveals the pathogenesis of uncomplicated urinary tract infection. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0502950102
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