The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Vacuolar Na + /H + antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca 2+ - and pH-dependent manner
Open accessAbstract
The selective movement of ions between intracellular compartments is fundamental for eukaryotes. Arabidopsis thaliana Na + /H + exchanger 1 (AtNHX1), the most abundant vacuolar Na + /H + antiporter in A. thaliana , has important roles affecting the maintenance of cellular pH, ion homeostasis, and the regulation of protein trafficking. Previously, we have shown that the AtNHX1 C-terminal hydrophilic region localized in the vacuolar lumen plays an important role in regulating the antiporter's activity. Here, we have identified A. thaliana calmodulin-like protein 15 (AtCaM15), which interacts with the AtNHX1 C terminus. When expressed in yeast, AtCaM15 is localized in the vacuolar lumen. The transient expression of AtCaM15 in Arabidopsis leaf protoplasts showed that AtCaM15 is present in the central vacuole. The binding of AtCaM15 to AtNHX1 was Ca 2+ - and pH-dependent and decreased with increasing pH values. Our results also show that the binding of AtCaM15 to AtNHX1 modified the Na + /K + selectivity of the antiporter, decreasing its Na + /H + exchange activity. Taken together, the presence of a vacuolar calmodulin-like protein acting on the vacuolar-localized AtNHX1 C terminus in a Ca 2+ - pH-dependent manner suggests the presence of signaling entities acting within the vacuole.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Salt Tolerance Conferred by Overexpression of a Vacuolar Na + /H + Antiport in Arabidopsis
Apse, M. P., Aharon, G. S., Snedden, W. A., & Blumwald, E. (1999) · Science · doi:10.1126/science.285.5431.1256 · Cited by 1,963
Self-citationFunctional analysis of oxidative stress-activated mitogen-activated protein kinase cascade in plants
Kovtun, Y., Chiu, W.-L., Tena, G., & Sheen, J. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2940 · Cited by 1,530
Phylogenetic Relationships within Cation Transporter Families of Arabidopsis
Mäser, P., Thomine, S., Schroeder, J. I., Ward, J. M., Hirschi, K., Sze, H., Talke, I. N., Amtmann, A., Maathuis, F. J. M., Sanders, D., et al. (2001) · Plant Physiology · doi:10.1104/pp.126.4.1646 · Cited by 1,257
Transgenic salt-tolerant tomato plants accumulate salt in foliage but not in fruit
Zhang, H.-X., & Blumwald, E. (2001) · Nature Biotechnology · doi:10.1038/90824 · Cited by 1,130
Self-citationSodium transport in plant cells
Blumwald, E., Aharon, G. S., & Apse, M. P. (2000) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(00)00135-8 · Cited by 993
Self-citationHow calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices
O'Neil, K. T., & DeGrado, W. F. (1990) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(90)90177-d · Cited by 842
Yokoi, S., Quintero, F. J., Cubero, B., Ruiz, M. T., Bressan, R. A., Hasegawa, P. M., & Pardo, J. M. (2002) · The Plant Journal · doi:10.1046/j.1365-313x.2002.01309.x · Cited by 586
Na+/H+ Exchangers of Mammalian Cells
Orlowski, J., & Grinstein, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22373 · Cited by 575
FM‐dyes as experimental probes for dissecting vesicle trafficking in living plant cells
Bolte, S., Talbot, C., Boutte, Y., Catrice, O., Read, N. D., & Satiat‐Jeunemaitre, B. (2004) · Journal of Microscopy · doi:10.1111/j.0022-2720.2004.01348.x · Cited by 572
Calmodulin as a versatile calcium signal transducer in plants
Snedden, W. A., & Fromm, H. (2001) · New Phytologist · doi:10.1046/j.1469-8137.2001.00154.x · Cited by 483
Cited by
Salinity tolerance in halophytes*
Flowers, T. J., & Colmer, T. D. (2008) · New Phytologist · doi:10.1111/j.1469-8137.2008.02531.x · Cited by 2,789
Shabala, S., & Pottosin, I. (2014) · Physiologia Plantarum · doi:10.1111/ppl.12165 · Cited by 720
Bassil, E., Tajima, H., Liang, Y.-C., Ohto, M.-A., Ushijima, K., Nakano, R., Esumi, T., Coku, A., Belmonte, M., & Blumwald, E. (2011) · The Plant Cell · doi:10.1105/tpc.111.089581 · Cited by 470
Self-citationPlant Salt Stress: Adaptive Responses, Tolerance Mechanism and Bioengineering for Salt Tolerance
Muchate, N. S., Nikalje, G. C., Rajurkar, N. S., Suprasanna, P., & Nikam, T. D. (2016) · The Botanical Review · doi:10.1007/s12229-016-9173-y · Cited by 359
Bassil, E., Coku, A., & Blumwald, E. (2012) · Journal of Experimental Botany · doi:10.1093/jxb/ers250 · Cited by 310
Self-citation
Metadata
- Authors
- Yamaguchi, T., Aharon, G. S., Sottosanto, J. B., & Blumwald, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-10-25
- Volume
- 102
- Issue
- 44
- Pages
- 16107-16112
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2134746340
- Cited by
- 257
- References
- 34
- FWCI
- 12.24
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Vacuolar Na + /H + antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca 2+ - and pH-dependent manner. https://app.cochat.ai/papers/10.1073/pnas.0504437102
- The paper
- Yamaguchi, T., Aharon, G. S., Sottosanto, J. B., & Blumwald, E. (2005). Vacuolar Na + /H + antiporter cation selectivity is regulated by calmodulin from within the vacuole in a Ca 2+ - and pH-dependent manner. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0504437102
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
