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Yeast prions [URE3] and [PSI + ] are diseases
Open accessAbstract
Viruses, plasmids, and prions can spread in nature despite being a burden to their hosts. Because a prion arises de novo in more than one in 10 6 yeast cells and spreads to all offspring in meiosis, its absence in wild strains would imply that it has a net deleterious effect on its host. Among 70 wild Saccharomyces strains, we found the [ PIN + ] prion in 11 strains, but the [URE3] and [ PSI + ] prions were uniformly absent. In contrast, the “selfish” 2μ DNA was in 38 wild strains and the selfish RNA replicons L-BC, 20S, and 23S were found in 8, 14, and 1 strains, respectively. The absence of [URE3] and [ PSI + ] in wild strains indicates that each prion has a net deleterious effect on its host.
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Cited by
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Halfmann, R., Jarosz, D. F., Jones, S. K., Chang, A., Lancaster, A. K., & Lindquist, S. (2012) · Nature · doi:10.1038/nature10875 · Cited by 401
Hillman, B. I., & Cai, G. (2013) · Advances in Virus Research · doi:10.1016/b978-0-12-394315-6.00006-4 · Cited by 269
Prion Switching in Response to Environmental Stress
Tyedmers, J., Madariaga, M. L., & Lindquist, S. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060294 · Cited by 263
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Wickner, R. B., Edskes, H. K., Shewmaker, F., & Nakayashiki, T. (2007) · Nature Reviews Microbiology · doi:10.1038/nrmicro1708 · Cited by 231
Self-citationProtein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms
Jarosz, D. F., Taipale, M., & Lindquist, S. (2010) · Annual Review of Genetics · doi:10.1146/annurev.genet.40.110405.090412 · Cited by 179
Metadata
- Authors
- Nakayashiki, T., Kurtzman, C. P., Edskes, H. K., & Wickner, R. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-07-15
- Volume
- 102
- Issue
- 30
- Pages
- 10575-10580
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010499900
- Cited by
- 245
- References
- 0
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- green
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- Nakayashiki, T., Kurtzman, C. P., Edskes, H. K., & Wickner, R. B. (2005). Yeast prions [URE3] and [PSI + ] are diseases. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0504882102
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