Cited by 179Evolution and Genetic DynamicsHeat shock proteins researchRNA and protein synthesis mechanisms

Protein Homeostasis and the Phenotypic Manifestation of Genetic Diversity: Principles and Mechanisms

Jarosz, Daniel F., Taipale, Mikko, Lindquist, Susan·2010·Annual Review of Genetics

Abstract

Changing a single nucleotide in a genome can have profound consequences under some conditions, but the same change can have no consequences under others. Indeed, organisms can be surprisingly robust to environmental and genetic perturbations. Yet, the mechanisms underlying such robustness are controversial. Moreover, how they might affect evolutionary change remains enigmatic. Here, we review the recently appreciated central role of protein homeostasis in buffering and potentiating genetic variation and discuss how these processes mediate the critical influence of the environment on the relationship between genotype and phenotype. Deciphering how robustness emerges from biological organization and the mechanisms by which it is overcome in changing environments will lead to a more complete understanding of both fundamental evolutionary processes and diverse human diseases.

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Crossref · 10.1146/annurev.genet.40.110405.090412

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200 of 200 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Hsp90's role as a capacitor for variation has been observed in diverse eukaryotes including flies, plants, and fungi.

    “This role as a capacitor for variation has been observed in diverse eukaryotes including flies, plants, and fungi18,19,129-134.”
  • Hsp90 can buffer the effects of genetic or epigenetic variation, keeping it silent until released when the chaperone reservoir is compromised in response to stress.

    “First, Hsp90 can buffer the effects of genetic or epigenetic variation, keeping it silent until released when the chaperone reservoir is compromised in response to stress.”

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Authors
Jarosz, D. F., Taipale, M., & Lindquist, S.
Affiliations
Howard Hughes Medical Institute (US)
Corresponding author
  • Jarosz, Daniel F.
  • Taipale, Mikko
Venue
Annual Review of Genetics
Published
2010-12-01
Volume
44
Issue
1
Pages
189-216
ISSN
  • 0066-4197 (ISSN-L)
  • 1545-2948
OpenAlex
W2147984622
Cited by
179
References
200
Citations by year
2026: 4 · 2025: 7 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 10 · 2020: 11 · 2019: 9 · 2018: 14 · 2017: 11 · 2016: 11 · 2015: 17 · 2014: 23 · 2013: 10 · 2012: 16
FWCI
1.29
Type
journal article
Language
en
Open access
closed
Locations
  • Annual Review of Genetics (publishedVersion)
  • PubMed (publishedVersion)
Funders
Howard Hughes Medical Institute
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
proteostasis, genetic robustness, genotype-phenotype correlation, environmental disturbance, evolutionary change, phenotypic plasticity, genetic diversity, human disease
MeSH terms
Animals, Biological Evolution, Homeostasis, Humans, Mutation, Phenotype, Proteins, Genetic Variation

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