The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane
Open accessAbstract
Misfolded proteins are eliminated from the endoplasmic reticulum (ER) by retrotranslocation into the cytosol, a pathway hijacked by certain viruses to destroy MHC class I heavy chains. The translocation of polypeptides across the ER membrane requires their polyubiquitination and subsequent extraction from the membrane by the p97 ATPase [also called valosin-containing protein (VCP) or, in yeast, Cdc48]. In higher eukaryotes, p97 is bound to the ER membrane by a membrane protein complex containing Derlin-1 and VCP-interacting membrane protein (VIMP). How the ubiquitination machinery is recruited to the p97/Derlin/VIMP complex is unclear. Here, we report that p97 interacts directly with several ubiquitin ligases and facilitates their recruitment to Derlin-1. During retrotranslocation, a substrate first interacts with Derlin-1 before p97 and other factors join the complex. These data, together with the fact that Derlin-1 is a multispanning membrane protein forming homo-oligomers, support the idea that Derlin-1 is part of a retrotranslocation channel that is associated with both the polyubiquitination and p97-ATPase machineries.
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Wiertz, E. J. H. J., Tortorella, D., Bogyo, M., Yu, J., Mothes, W., Jones, T. R., Rapoport, T. A., & Ploegh, H. L. (1996) · Nature · doi:10.1038/384432a0 · Cited by 1,105
Self-citationThe AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
Ye, Y., Meyer, H. H., & Rapoport, T. A. (2001) · Nature · doi:10.1038/414652a · Cited by 1,099
Self-citationWiertz, E. J. H. J., Jones, T. R., Sun, L., Bogyo, M., Geuze, H. J., & Ploegh, H. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81054-5 · Cited by 1,072
Self-citationA Novel Ubiquitination Factor, E4, Is Involved in Multiubiquitin Chain Assembly
Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H. D., Mayer, T. U., & Jentsch, S. (1999) · Cell · doi:10.1016/s0092-8674(00)80574-7 · Cited by 1,056
Imai, Y., Soda, M., Inoue, H., Hattori, N., Mizuno, Y., & Takahashi, R. (2001) · Cell · doi:10.1016/s0092-8674(01)00407-x · Cited by 1,050
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins
Connell, P., Ballinger, C. A., Jiang, J., Wu, Y., Thompson, L. J., Höhfeld, J., & Patterson, C. (2001) · Nature Cell Biology · doi:10.1038/35050618 · Cited by 997
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
Ye, Y., Shibata, Y., Yun, C., Ron, D., & Rapoport, T. A. (2004) · Nature · doi:10.1038/nature02656 · Cited by 963
Self-citationThe Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
Meacham, G. C., Patterson, C., Zhang, W., Younger, J. M., & Cyr, D. M. (2001) · Nature Cell Biology · doi:10.1038/35050509 · Cited by 839
Viral Subversion of the Immune System
Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 835
A membrane protein required for dislocation of misfolded proteins from the ER
Lilley, B. N., & Ploegh, H. L. (2004) · Nature · doi:10.1038/nature02592 · Cited by 674
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Metadata
- Authors
- Ye, Y., Shibata, Y., Kikkert, M., van Voorden, S., Wiertz, E., & Rapoport, T. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-09-26
- Volume
- 102
- Issue
- 40
- Pages
- 14132-14138
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2010862596
- Cited by
- 311
- References
- 29
- FWCI
- 10.76
- Type
- journal article
- Language
- en
- Open access
- green
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- Ye, Y., Shibata, Y., Kikkert, M., van Voorden, S., Wiertz, E., & Rapoport, T. A. (2005). Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0505006102
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