The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways
Open accessAbstract
Endoplasmic reticulum (ER)-associated degradation (ERAD) and the unfolded protein response (UPR) are two key quality-control machineries in the cell. ERAD is responsible for the clearance of misfolded proteins in the ER for cytosolic proteasomal degradation, while UPR is activated in response to the accumulation of misfolded proteins. It has long been thought that ERAD is an integral part of UPR because expression of many ERAD genes is controlled by UPR; however, recent studies have suggested that ERAD has a direct role in controlling the protein turnover and abundance of IRE1α, the most conserved UPR sensor. Here, we review recent advances in our understanding of IRE1α activation and propose that UPR and ERAD engage in an intimate crosstalk to define folding capacity and maintain homeostasis in the ER.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing
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UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
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The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
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The unfolded protein response signals through high-order assembly of Ire1
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Quality and quantity control at the endoplasmic reticulum
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Wu, S. A., Kersten, S., & Qi, L. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.11.005 · Cited by 225
Self-citationSigma-1 receptor: a potential therapeutic target for traumatic brain injury
Shi, M., Chen, F., Chen, Z., Yang, W., Yue, S., Zhang, J., & Chen, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.685201 · Cited by 58
Miao, X., Wu, J., Chen, H., & Lu, G. (2022) · Nutrients · doi:10.3390/nu14091690 · Cited by 13
Metadata
- Authors
- Hwang, J., & Qi, L.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 43
- Issue
- 8
- Pages
- 593-605
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2811301994
- Cited by
- 592
- References
- 9
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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