The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer
Open accessAbstract
We show that atypical PKCι, which plays a critical role in the establishment and maintenance of epithelial cell polarity, is genomically amplified and overexpressed in serous epithelial ovarian cancers. Furthermore, PKCι protein is markedly increased or mislocalized in all serous ovarian cancers. An increased PKC ι DNA copy number is associated with decreased progression-free survival in serous epithelial ovarian cancers. In a Drosophila in vivo epithelial tissue model, overexpression of persistently active atypical PKC results in defects in apical-basal polarity, increased Cyclin E protein expression, and increased proliferation. Similar to the Drosophila model, increased PKCι proteins levels are associated with increased Cyclin E protein expression and proliferation in ovarian cancers. In nonserous ovarian cancers, increased PKCι protein levels, particularly in the presence of Cyclin E, are associated with markedly decreased overall survival. These results implicate PKCι as a potential oncogene in ovarian cancer regulating epithelial cell polarity and proliferation and suggest that PKCι is a novel target for therapy.
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Macara, I. G. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1332 · Cited by 341
Tinkle, C. L., Lechler, T., Pasolli, H. A., & Fuchs, E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307437100 · Cited by 193
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Mosesson, Y., Mills, G. B., & Yarden, Y. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2521 · Cited by 718
Self-citationPKC and the control of localized signal dynamics
Rosse, C., Linch, M., Kermorgant, S., Cameron, A. J. M., Boeckeler, K., & Parker, P. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2847 · Cited by 477
Cell polarity in development and cancer
Wodarz, A., & Näthke, I. (2007) · Nature Cell Biology · doi:10.1038/ncb433 · Cited by 395
Metadata
- Authors
- Eder, A. M., Sui, X., Rosen, D. G., Nolden, L. K., Cheng, K. W., Lahad, J. P., Kango-Singh, M., Lu, K. H., Warneke, C. L., Atkinson, E. N., Bedrosian, I., Keyomarsi, K., Kuo, W.-L., Gray, J. W., Yin, J. C. P., Liu, J., Halder, G., & Mills, G. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2005-08-22
- Volume
- 102
- Issue
- 35
- Pages
- 12519-12524
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2154122181
- Cited by
- 238
- References
- 2
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- green
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- The paper
- Eder, A. M., Sui, X., Rosen, D. G., Nolden, L. K., Cheng, K. W., Lahad, J. P., Kango-Singh, M., Lu, K. H., Warneke, C. L., Atkinson, E. N., Bedrosian, I., Keyomarsi, K., Kuo, W.-L., Gray, J. W., Yin, J. C. P., Liu, J., Halder, G., & Mills, G. B. (2005). Atypical PKCι contributes to poor prognosis through loss of apical-basal polarity and Cyclin E overexpression in ovarian cancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.0505641102
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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