The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Cell polarity in development and cancer
Open accessAbstract
The development of cancer is a multistep process in which the DNA of a single cell accumulates mutations in genes that control essential cellular processes. Loss of cell–cell adhesion and cell polarity is commonly observed in advanced tumours and correlates well with their invasion into adjacent tissues and the formation of metastases. Growing evidence indicates that loss of cell–cell adhesion and cell polarity may also be important in early stages of cancer. The strongest hints in this direction come from studies on tumour suppressor genes in the fruitfly Drosophila melanogaster, which have revealed their importance in the control of apical–basal cell polarity.
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Citations
Cites
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
Lechler, T., & Fuchs, E. (2005) · Nature · doi:10.1038/nature03922 · Cited by 998
Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716
Gateff, E. (1978) · Science · doi:10.1126/science.96525 · Cited by 461 · cited 1×
“The best studied of these genes are the so-called neoplastic tumour suppressors lethal giant larvae ( lgl ), discs large ( dlg ) and scribble ( scrib”
BackgroundIntegrated activity of PDZ protein complexes regulates epithelial polarity
Bilder, D., Schober, M., & Perrimon, N. (2003) · Nature Cell Biology · doi:10.1038/ncb897 · Cited by 435
Qin, Y., Capaldo, C., Gumbiner, B. M., & Macara, I. G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200506094 · Cited by 285
Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble
Zeitler, J., Hsu, C. P., Dionne, H., & Bilder, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200407158 · Cited by 135
Cited by
Coordinated protein sorting, targeting and distribution in polarized cells
Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2525 · Cited by 521
Nicolas, J., Magli, S., Rabbachin, L., Sampaolesi, S., Nicotra, F., & Russo, L. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00045 · Cited by 509
Crosstalk between small GTPases and polarity proteins in cell polarization
Iden, S., & Collard, J. G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2521 · Cited by 451
Neural stem cells: balancing self-renewal with differentiation
Doe, C. Q. (2008) · Development · doi:10.1242/dev.014977 · Cited by 420
Phosphoinositide signalling in cancer: beyond PI3K and PTEN
Bunney, T. D., & Katan, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2842 · Cited by 400
Metadata
- Authors
- Wodarz, A., & Näthke, I.
- Venue
- Nature Cell Biology
- Published
- 2007-09
- Volume
- 9
- Issue
- 9
- Pages
- 1016-1024
- ISSN
- 1465-7392 (ISSN-L)
- 1476-4679
- OpenAlex
- W2008939826
- Cited by
- 395
- References
- 6
- FWCI
- 10.06
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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